The Gov. of the USA, as represented by Secretary, Department of Health and Human Services
The Gov. of the USA, as represented by Secretary, Department of Health and Human Services Patent applications | ||
Patent application number | Title | Published |
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20090041804 | Recombinant vector expressing multiple costimulatory molecules and uses thereof - The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of Tell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4 | 02-12-2009 |