The Charles Stark Draper Laboratory, Inc. Patent applications |
Patent application number | Title | Published |
20160043043 | DEVICES AND METHODS FOR DETECTING COUNTERFEIT SEMICONDUCTOR DEVICES - Techniques for providing a tamper mechanism for semiconductor devices are disclosed herein. The techniques include, for example, providing at least one die and at least one strain gauge, orienting the at least one strain gauge to the die, forming an encapsulated semiconductor device by encapsulating the die and each strain gauge within a mold compound to maintain respective orientation, and measuring an initial strain value for the at least one strain gauge after forming the encapsulated semiconductor device. | 02-11-2016 |
20160040112 | FLUID CIRCULATION SYSTEMS INCORPORATING FLUID LEVELING DEVICES - Fluid circulation and leveling systems and methods of using the same are described. A fluid circulation system includes a fluid mixing chamber and open fluid chambers in fluid communication with the fluid mixing chamber. Each open fluid chamber includes a microfluidic fluid leveling conduit with an orifice disposed in the open fluid chamber at a minimum fluid level associated with a corresponding minimum fluid volume. A controller causes a first pump to generate a first direction of fluid flow during a first time period between the open fluid chambers, and causes the first pump to generate a second direction of fluid flow during a second time period between the first and second open fluid chambers. The controller also causes a second pump to generate a flow of fluid during a third time period from one of the first and second open fluid chambers into the fluid mixing chamber. | 02-11-2016 |
20150198557 | THREE-DIMENSIONAL METAL ION SENSOR ARRAYS ON PRINTED CIRCUIT BOARDS - An electronic device includes a substrate and a plurality of sensors. Each sensor is disposed in a well over the substrate and includes a working electrode, an inner filling solution disposed thereover, and an ion-selective membrane. The working electrode is in contact with the substrate and the ion-selective membrane is disposed over the inner filling solution and substantially seals the well. | 07-16-2015 |
20150194046 | METHODS AND SYSTEMS FOR DETERMINING COMPROMISED HIGH SPEED DATA CHANNELS - An Integrated Circuit (IC) determines tampering of a communication channel between one or more components by determining, via a channel equalizer coupled to the communication channel, filter coefficients of the communication channel. The IC further compares, via a comparator, the filter coefficients to a tamper threshold and indicates tampering of the data channel when the tamper threshold is exceeded. The tamper threshold is determined by the channel equalizer based, in part, on initial filter coefficients. | 07-09-2015 |
20150181709 | ELECTRONIC MODULE SUBASSEMBLIES AND METHODS FOR FABRICATING THE SAME - An electronic module subassembly including a substrate. The substrate includes a bottom laminate, a middle laminate coupled to the bottom laminate, and a top laminate coupled to the middle laminate. The middle laminate has a plurality of web areas, each web area defining at least one hole. The defines a planar top surface and a plurality of open areas corresponding to and aligned with the plurality of web areas. First components have a first thickness. At least one first component is in each of the open areas. Second components have a second thickness relatively larger than the first thickness. At least one second component is in each of the open areas. The second components extend into the respective at least one hole of the web areas. Encapsulant fills in the open areas and the web areas. | 06-25-2015 |
20150179609 | METHOD FOR INTERCONNECTING DIE AND SUBSTRATE IN AN ELECTRONIC PACKAGE - A method for interconnecting a die on a substrate of an electronic package. The method includes the steps of forming a plurality of free-end wire bonds on the die, wherein the free-end wire bonds are upstanding from the die, and encapsulating the free-end wire bonds in an encapsulation layer. Planarizing the encapsulation layer is performed so that the free-end wire bonds are exposed for electrical connection. Interconnecting the free-end wire bonds is provided by applying an interconnection layer on the encapsulation layer. | 06-25-2015 |
20150121246 | SYSTEMS AND METHODS FOR DETECTING USER ENGAGEMENT IN CONTEXT USING PHYSIOLOGICAL AND BEHAVIORAL MEASUREMENT - The present disclosure is directed to an engagement-adaptive system. The system includes a content delivery module configured to deliver content to a user, a context logger configured to associate events in the delivered content with temporal locations in a first time-series. The system also includes an indicator measurement module configured to measure at least one engagement indicator and associate the measurements with temporal locations in a second time-series. The system includes an engagement analysis module configured to generate at least one engagement value based on a calculated relationship between the first and second time-series and an adaptation module configured to receive the at least one engagement value and modify execution of computer executable instructions by a processor based on the received engagement value. | 04-30-2015 |
20150084585 | SMART IMPLANT BATTERY CHARGER - According one aspects, embodiments herein provide an inductive localization and charging system for detecting and charging a medical device comprising a plurality of primary inductive coils arranged within a dielectric material, an input connector coupled to the plurality of primary inductive coils and configured to receive input power, a controller coupled to the plurality of primary inductive coils and to the input connector, the controller configured to selectively activate each primary coil of the plurality of primary inductive coils, determine that a first primary coil of the plurality of primary inductive coils is within operable proximity of an external secondary coil located in the medical device, and control transfer of power between the primary coil and the secondary coil to charge the medical device. | 03-26-2015 |
20150054589 | RADIATION-HARD PRECISION VOLTAGE REFERENCE - According to one aspect, embodiments herein provide a PVR comprising a resonator having an oscillation frequency, the resonator comprising at least one proof-mass, a mechanical reference, at least one drive plate located adjacent a first side of the at least one proof-mass, and at least one sense plate located adjacent a second side of the at least one proof-mass, a voltage source coupled to the drive and sense plates, a reference oscillator configured to provide a reference signal having a reference frequency to the voltage source; and an output, wherein the voltage source is configured to provide a bias voltage signal to the at least one drive and at least one sense plates of the resonator to drive the oscillation frequency of the resonator to match the reference frequency, and wherein the bias voltage signal is also provided to the output of the PVR as a voltage reference signal. | 02-26-2015 |
20140330089 | PHYSIOLOGICAL FEATURE EXTRACTION AND FUSION TO ASSIST IN THE DIAGNOSIS OF POST-TRAUMATIC STRESS DISORDER - Post-traumatic stress disorder (PTSD), and other anxiety disorders, are diagnosed via clinical interviews in which subjective self-reports of traumatic events and associated experiences are discussed with a mental health professional. The system and methods described herein classify and diagnose patients as suffering from anxiety disorders by measuring objective physiological measures, such as inter-heartbeat interval and skin conductance. The system measures various physiological measures and then extracts features from the physiological measures. A diagnosis is then made by classifying the extracted features using one of a neural network, Bayesian network, or a support vector machine. | 11-06-2014 |
20140273345 | METHODS FOR BONDING A HERMETIC MODULE TO AN ELECTRODE ARRAY - A method for bonding a hermetic module to an electrode array including the steps of: providing the electrode array having a flexible substrate with a top surface and a bottom surface and including a plurality of pads in the top surface of the substrate; attaching the hermetic module to the bottom surface of the electrode array, the hermetic module having a plurality of bond-pads wherein each bond-pad is adjacent to the bottom surface of the electrode array and aligns with a respective pad; drill holes through each pad to the corresponding bond-pad; filling each hole with biocompatible conductive ink; forming a rivet on the biocompatible conductive ink over each pad; and overmolding the electrode array with a moisture barrier material. | 09-18-2014 |
20140273276 | SYSTEM AND METHOD FOR A MICROFLUIDIC CALORIMETER - Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel. | 09-18-2014 |
20140267755 | HIGH PERFORMANCE SCANNING MINIATURE STAR CAMERA SYSTEM - A star camera system that includes an optical system configured to focus radiation from a star to be imaged onto a collector that is in the form of an electron bombarded active pixel sensor (EBAPS) configured to provide high gain. The EBAPS comprising a photocathode disposed in a vacuum is configured to release electrons into the vacuum when exposed to radiation focused thereon by the optical system. The EBAPS includes an active pixel sensor anode disposed distant from the photocathode in the vacuum. An electric field is generated by a voltage source to direct the electrons from the photocathode to the active pixel sensor anode. Furthermore, the collector is mounted on a translation device configured to move the collector relative to the optical system by a predetermined amount of less than pixel size in the focal plane of the optical system to increase image resolution of a plurality of images. | 09-18-2014 |
20140267641 | ELECTRON-BOMBARDED ACTIVE PIXEL SENSOR STAR CAMERA - A star camera system that includes an optical system configured to focus radiation from a star to be imaged onto a collector. Specifically, the collector is in the form of an electron bombarded active pixel sensor (EBAPS) configured to provide high gain. The EBAPS comprising a photocathode disposed in a vacuum is configured to release electron into a vacuum when exposed to radiation focused thereon by the optical system. In addition, the EBAPS includes an active pixel sensor anode disposed distant from the photocathode in the vacuum. An electric field is generated by a voltage source to direct electrons from the photocathode to the active pixel sensor anode to thereby generate an image of the star. | 09-18-2014 |
20140257435 | DISTRIBUTED NEURO-MODULATION SYSTEM WITH AUXILIARY STIMULATION-RECORDING CONTROL UNITS - Systems and methods for modulating a physiological process are provided to enable precise delivery of signals to a predetermined treatment site. The systems may comprise an implantable device and an electrical lead body. The electrical lead body may comprise a plurality of transducer contacts in close proximity to an end of the electrical lead body, and a control unit positioned within the lead body in close proximity to the plurality of transducer contacts. | 09-11-2014 |
20140257434 | DISTRIBUTED NEURO-MODULATION SYSTEM WITH AUXILIARY STIMULATION-RECORDING CONTROL UNITS - Systems and methods for modulating a physiological process are provided to enable precise delivery of signals to a predetermined treatment site. The systems may comprise an implantable device and an electrical lead body. The electrical lead body may comprise a plurality of transducer contacts in close proximity to an end of the electrical lead body, and a control unit positioned within the lead body in close proximity to the plurality of transducer contacts. | 09-11-2014 |
20140255470 | MULTIVALENT LIPOSOME FORMULATIONS - This disclosure provides compositions, kits, and methods useful for treating or preventing viral and bacterial infection and reducing or preventing the effects of toxins. The methods comprise administering to a subject an effective amount of a liposomal composition. | 09-11-2014 |
20140234381 | SCAFFOLD FOR SUBRETINAL CELL TRANSPLANTATION AND DRUG DELIVERY - The following disclosure provides compositions and methods for the repairing of a diseased or disordered retina, for example, in patients suffering from age-related macular degeneration (AMD). | 08-21-2014 |
20140212964 | MODULAR PLATFORM FOR MULTI-TISSUE INTEGRATED CELL CULTURE - The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the organ systems are fluidically connected with a constant-volume pump. | 07-31-2014 |
20140209542 | EXTRACORPOREAL CLEARANCE OF ORGANOPHOSPHATES FROM BLOOD ON AN ACOUSTIC SEPARATION DEVICE - Systems, methods, and compositions for removing organophosphate toxins from blood are disclosed herein. The compositions include a lipid-based capture particle that displays BChE that binds to the toxin. The methods include acoustically separating toxins bound to lipid-based capture particles from blood factors of whole blood. | 07-31-2014 |
20140206940 | METHOD OF TISSUE SEPARATION USING FLUIDIC PULSES TO MINIMIZE TISSUE TRAUMA DURING CATHETER INSERTION - The method and system disclosed herein uses a pulsatile, dilatory bubble at the tip of a catheter to facilitate tissue separation and ease catheter insertion for, among other applications, delivery of therapeutics to the posterior of the eye while reducing procedure-related trauma. In some implementations, the method is extended to other dilatory and catheter-insertion applications elsewhere in the body. In brief, the disclosure discusses iteratively injecting liquid through a catheter to form a bubble near the distal tip of the catheter. The liquid is withdrawn to create a void, and the catheter is advanced into the void. The process is repeated until the distal tip of the catheter reaches the target location. | 07-24-2014 |
20140197105 | SYSTEMS AND METHODS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE - A microfluidic device for increasing convective clearance of particles from a fluid is provided. A network of first channels can be separated from a network of second channels by a first membrane. The network of first channels can also be separated from a network of third channels by a second membrane. Fluid containing an analyte can be introduced in the network of first channels. Infusate can be introduced into the network of second channels, and waste-collecting fluid can be introduced into the network of third channels. A pressure gradient can be applied in a direction perpendicular to the direction of fluid flow in the network of first channels, such that the analyte is transported from the network of first channels into the network of third channels through the second membrane. | 07-17-2014 |
20140197101 | SYSTEMS AND METHODS FOR INCREASING CONVECTIVE CLEARANCE OF UNDESIRED PARTICLES IN A MICROFLUIDIC DEVICE - A microfluidic device for increasing convective clearance of particles from a liquid is provided. A network of first channels can be separated from a network of second channels by a membrane. The network of second channels can include a pressurizing feature to create a high pressure at an upstream portion of the second channels and a low pressure at a downstream portion of the second channels. Liquid containing an analyte can be introduced in the network of first channels. Filtrate can be flowed through the pressurizing feature in the second channels, such that the pressure difference in between the first and second channels causes at least some of the analyte in the first liquid is transported into the second channels through the membrane. | 07-17-2014 |
20140193031 | COMPRESSIVE SENSING WITH LOCAL GEOMETRIC FEATURES - Methods and apparatuses for compressive sensing that enable efficient recovery of features in an input signal based on acquiring a few measurements corresponding to the input signal. One method of compressive sensing includes folding an image to generate first and second folds, and recovering a feature of the image based on the first and second folds without reconstructing the image. One example of a compressive sensing apparatus includes a lens, a focal plane array coupled to the lens and configured to generate first and second folds based on the image, and a decoder configured to receive the first and second folds and to recover a feature of the image without reconstructing the image. The feature may be a local geometric feature or a corner. Compressive sensing methods and apparatuses for determining translation and rotation between two images are also disclosed. | 07-10-2014 |
20140127733 | EX VIVO MICROFLUIDIC ANALYSIS OF BIOLOGIC SAMPLES - Systems and methods for culturing and monitoring, ex vivo, pharmacologic and metabolic response in a biological sample, including receiving at a fluidic apparatus the biological sample retrieved from the patient, retaining the biological sample within a channel of the fluidic apparatus, providing for the culture of the biological sample within the channel of the fluidic apparatus, flowing a fluid past the biological sample, retrieving and analyzing the fluid to determine a pharmacologic and/or metabolic response of the sample. | 05-08-2014 |
20140074135 | SMALL DIAMETER LAPAROSCOPIC TOOL HAVING RELEASABLE TIP - A laparoscopy tool includes a sheath and a control wire slideably disposed within a lumen of the sheath. The sheath has a diameter of less than 1.6 mm and is introduced through an abdominal incision. A handle axially displaces the control wire within the lumen and operates a conventional tip with wire-controlled opposing jaws that is introduced through the umbilicus and has a bore formed in its trailing end. A first set of blades in the bore engage grooves formed in the leading end of the control wire and a second set of blades engages the sheath to prevent sheath retraction. A cam displaces the second set of blades away from the sheath for sheath introduction and removal, and toward the sheath to prevent sheath retraction. The tip is removed through the umbilicus and the tool is removed through the abdominal incision when the surgery is completed. | 03-13-2014 |
20140073992 | APPARATUS AND METHOD FOR MANUALLY POWERED BODILY FLUID EXTRACTION - Apparatuses and methods are disclosed herein for extracting bodily fluids. The apparatus consists of a housing, a releasable lancet stored in the housing, an inlet flow channel formed in the housing, a mechanically powered vacuum generator, and a storage area formed in the housing. The releasable lancet is released to pierce the skin of the subject to allow fluid to be extracted from the subject. The vacuum generator generates a partial vacuum within the inlet flow channel. After the lancet has pierced the skin of the subject, the partial vacuum draws fluid from the subject and into the inlet flow channel. The storage area is in fluid connection with the inlet flow channel, and receives the fluid drawn from the subject from the inlet flow channel. | 03-13-2014 |
20140061115 | COMPACT HYDRAULIC MANIFOLD STRUCTURE FOR SHEAR SENSITIVE FLUIDS - An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device. | 03-06-2014 |
20130331728 | METHOD AND APPARATUS FOR DETERMINING A CORE TEMPERATURE OF AN INTERNAL ORGAN - Systems and methods of determining a core temperature of an internal organ in a body are provided. A thermal mass of known thermal resistance can be located between a body-contacting substrate and an external substrate. The body-contacting portion of the substrate can be placed over the organ whose temperature is to be measured. Temperature sensors can measure a temperature difference across the thermal mass and an absolute temperature at the external portion of the substrate. An electronic processor can receive the temperature measurements and can compute the core temperature of the organ based on the temperature measurements and the thermal resistances of the thermal mass and the tissue surrounding the organ. | 12-12-2013 |
20130331589 | CHEMICAL COMPOSITION - Chemical compositions, lubricant compositions, and methods of using the same are provided. The lubricant composition may comprise at least on carrier. In certain methods, the lubricant composition may be provided to at least one surface, wherein the lubricant composition reduces a coefficient of friction of the at least one surface. In certain methods, the lubricant composition may be provided to at least one surface, wherein the lubricant composition reduces wear of the at least one surface. | 12-12-2013 |
20130329376 | ELECTRONIC MODULES - Electronic modules are formed by encapsulating microelectronic dies within cavities in a substrate. | 12-12-2013 |
20130329373 | BIO-IMPLANTABLE HERMETIC INTEGRATED ULTRA HIGH DENSITY DEVICE - An implantable bio-compatible integrated circuit device and methods for manufacture thereof are disclosed herein. The device includes a substrate having a recess. An input/output device including at least one bio-compatible electrical contact is coupled to the substrate in the recess. A layer of hermetic bio-compatible, hermetic insulator material is deposited on a portion of the input/output device. An encapsulating layer of bio-compatible material encapsulates at least a portion of the implantable device, including the input/output device. At least one bio-compatible electrical contact of the input/output device is then exposed. The encapsulating layer and the layer of bio-compatible, hermetic insulator material form a hermetic seal around the at least one exposed bio-compatible electrical contact. | 12-12-2013 |
20130327594 | LUBRICANT COMPOSITION AND METHODS OF USING SAME - Chemical compositions, lubricant compositions, and methods of using the same are provided. The lubricant composition may comprise at least on carrier. In certain methods, the lubricant composition may be provided to at least one surface, wherein the lubricant composition reduces a coefficient of friction of the at least one surface. In certain methods, the lubricant composition may be provided to at least one surface, wherein the lubricant composition reduces wear of the at least one surface. | 12-12-2013 |
20130314509 | LONG FOCAL LENGTH MONOCULAR 3D IMAGER - An optical assembly for three-dimensional image capture includes first and second optical channels that are fixed with respect to one another. Each channel is configured to direct light onto at least a portion of an image sensor. The first and second optical channels each include an aperture for receiving the light, an objective lens for focusing the light into an intermediate image on an intermediate image plane, and an eyepiece lens for collimating the intermediate image. | 11-28-2013 |
20130230911 | POROUS STRUCTURE WITH INDEPENDENTLY CONTROLLED SURFACE PATTERNS - Disclosed herein are systems and methods for manufacturing and using a cell culture support device. The device includes a plurality of polymer layers, each with at least one flow chamber defined therethrough. The device also includes a cross channel interface between the channels of different polymer layers. The cross channel interface includes a plurality of pores and a topographical pattern that is selected independent of the plurality of pores. Furthermore, the formation of the topographical pattern preservers the pores. | 09-05-2013 |
20130207975 | SYSTEMS AND METHODS FOR SPATIO-TEMPORAL ANALYSIS - High resolution time sequences of 3D images that show the dynamics of a time varying changes are provided. The 3D time series of images representing an object that include time varying changes may be produced from lower dimensional image time sequences, such as 2D images. The 2D images may be generated using angiography and may include fluid flow information (e.g., arrival times). The fluid flow information may be provided, for example, by injecting a chemical into the fluid and analyzing its position in the object or body over time. A varying contrast model may be applied to determine the location of the chemical at different points in time which may assist in detecting an ailment. | 08-15-2013 |
20130203086 | MICROFLUIDIC DEVICE FOR GENERATING NEURAL CELLS TO SIMULATE POST-STROKE CONDITIONS - This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels. | 08-08-2013 |
20130194770 | MEMS VIBRATION ISOLATION SYSTEM AND METHOD - A microelectromechanical vibration isolation system includes a microelectromechanical structure having a plurality of fin apertures etched therethrough, and a plurality of fins each disposed within a respective one of the plurality of fin apertures and spaced apart from the microelectromechanical structure so as to define a fluid gap therebetween. The fluid gap is configured to provide squeeze film damping of vibrations imparted upon the microelectromechanical structure in at least two dimensions. The system further includes a frame surrounding the microelectromechanical structure, and a plurality of springs each coupled to the microelectromechanical structure and to the frame. The plurality of springs is configured to support the micromechanical structure in relation to the frame. | 08-01-2013 |
20130183707 | STEM CELL BIOINFORMATICS - Ex vivo cell culture, especially the culture of stem cells, is a valuable and widely used technique. The appearance of unlabeled cultured cells contains significant information about the cell's identity, including its differentiation status and lineage. However, mere visual inspection of cells is a subjective process subject to inconsistencies between microscopists. This disclosure provides methods of quantifying cells' appearance, validating identity with known biomarkers, allowing automated classification of cells as well as automated segmentation and delineation of the borders of a cell colony. Also provided are systems and methods for comparing and standardizing cells cultured by different scientists using different cell culture methods. | 07-18-2013 |
20130168541 | ADIABATIC RAPID PASSAGE ATOMIC BEAMSPLITTER USING FREQUENCY-SWEPT COHERENT LASER BEAM PAIRS - Methods and apparatus for providing coherent atom population transfer using coherent laser beam pairs in which the frequency difference between the beams of a pair is swept over time. Certain examples include a Raman pulse adiabatic rapid passage sweep regimen configured to be used as a beamsplitter and combiner in conjunction with an adiabatic rapid passage mirror sweep or a standard Raman mirror pulse in a 3-pulse interferometer sequence. | 07-04-2013 |
20130144266 | METHODS FOR REDUCING THE BLOOD PRIMING VOLUME AND MEMBRANE SURFACE AREA IN MICROFLUIDIC LUNG ASSIST DEVICES - A device and method for oxygenating blood is disclosed herein. The device includes a plurality of passive mixing elements that causes a fluid to mix as it flows through the device. The passive mixing elements continually expose new red blood cells to the portion of the flow channel where oxygenation can occur. Accordingly, in some implementations, the device and method uses less blood to prime the device and allows for the oxygenation of blood with a substantial shorter flow channel when compared to conventional oxygenation methods and devices. | 06-06-2013 |
20130106648 | SHORT-RANGE HOMODYNE RADAR SYSTEM | 05-02-2013 |
20130104653 | MEMS HEMISPHERICAL RESONATOR GYROSCOPE | 05-02-2013 |
20130098866 | ROTARY NANOTUBE BEARING STRUCTURE AND METHODS FOR MANUFACTURING AND USING THE SAME - In one embodiment, a rotary device includes a multiwall nanotube that extends substantially perpendicularly from a substrate. A rotor may be coupled to an outer wall of the multiwall nanotube, be spaced apart from the substrate, and be free to rotate around an elongate axis of the multiwall nanotube. | 04-25-2013 |
20130040783 | EXOSKELETON SUIT FOR ADAPTIVE RESISTANCE TO MOVEMENT - Systems and methods are disclosed herein for providing resistance to movement of a wearer. The system includes a plurality of wearable actuators, a plurality of wearable sensors, and a processor. Each of the wearable sensors measures an indication of an orientation of a corresponding one of the wearable actuators with respect to a vertical direction. Each of the sensors also measures an indication of a motion experienced by the corresponding one of the wearable actuators. The processor receives data from each sensor indicating the orientation and the motion of the sensor. The processor determines an amount of resistance to apply using each of the actuators based on the vertical direction and sends instructions to the actuators. The instructions cause the actuators to apply a resistance to the wearer. | 02-14-2013 |
20130018267 | ELECTRONIC CATHETER STETHOSCOPE - An electronic catheter stethoscope measures and analyzes acoustic fields and dynamic pressure variations in the gaseous or liquid fluid inside a conventional medical catheter that is positioned in a patient's urologic, digestive, reproductive, cardiovascular, neurological or pulmonary system. Measurement transducers are installed in a housing connectable to multiple preselected medical catheters. The transducers detect bodily functions that are transmitted to the preselected catheter from within the body. The transducers, housing, electrical interface and signal processing electronics are positioned outside the body. | 01-17-2013 |
20120322097 | DEVICE AND METHOD FOR CULTURING CELLS IN A BIOMIMETIC ENVIRONMENT - Devices and methods are disclosed herein for a biomimetic flow apparatus. The biomimetic flow apparatus includes a microfluidic flow channel and an inlet in fluid connection with the flow channel for allowing fluid to flow into the flow channel. The flow channel has at least one surface with a topography formed therein. The topography of the at least one surface of the flow channel is selected to cause cells in a cell layer above the surface to achieve an arrangement, behavior, or morphology. The cell arrangement, behavior, or morphology is determined at least in part by the topography of the at least one surface. | 12-20-2012 |
20120318726 | SYSTEMS, METHODS, AND DEVICES RELATING TO A BIOMIMETIC CELLULARIZED NEPHRON UNIT - Disclosed herein are systems and devices for culturing cells in a biomimetic environment of a cellularized nephron unit, and methods for fabricating and using the cellularized nephron unit. | 12-20-2012 |
20120286995 | SYSTEMS AND METHODS FOR CLOCK CORRECTION - A non-GPS satellite-based system enables correction of a local clock in a user device to facilitate GPS-based location determination. | 11-15-2012 |
20120280108 | SYSTEMS AND METHODS FOR ADDING OR SUBTRACTING PIXELS - A pixel array including circuitry for combining charges accumulated by individual pixels in the array enables addition and/or subtraction of individual pixel values, prior to their digitization, in the pixel array. | 11-08-2012 |
20120264224 | SYSTEM AND METHOD FOR A MICROFLUIDIC CALORIMETER - Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel. | 10-18-2012 |
20120256038 | SYSTEMS AND METHODS FOR TARGETING A PROJECTILE PAYLOAD - A projectile's payload is oriented (independently or by orientation of the projectile itself) toward a target just prior to firing (e.g., detonation of the payload), e.g., for munitions providing an increased kill and casualty area and a fire “in defilade” (left, right, backwards or at any angle) capability. | 10-11-2012 |
20120221889 | SYSTEM AND METHOD FOR DUPLEXED REPLICATED COMPUTING - Systems and methods are disclosed herein for a replicated duplex computer system. The system includes a triplet of network elements, which each maintain a clock signal, and a monitor at each network element for monitoring incoming clock signals. Each network element interfaces with a fault containment region (FCR). The system provides the ability to transition to a duplex system if one of the fault containment regions fails. The three network elements are able to send their clock signals to the other network elements and receive their own clock signal and clock signals from the other elements. The monitors are configured to detect discrepancies in the clock signals of the network elements. If a monitor determines that an FCR has failed, each network element is reconfigured so that the FTPP system operates in a duplex mode without the faulty FCR by replacing the clock signal from the faulty element with its own clock signal. | 08-30-2012 |
20120192622 | GEO-LOCATION SYSTEMS AND METHODS BASED ON ATMOSPHERIC PRESSURE MEASUREMENT - System and method for geo-location of a device (such as a tag) using barometric pressure readings taken in the vicinity of the device and correlated to datasets of barometric pressure that have pressure gradients over time and space. The readings taken in the vicinity of the device may be correlated to the datasets using an iterative Bayesian approach to determine a geo-location of the device with a high degree of confidence. | 08-02-2012 |
20120149021 | Device for Filtration of Fluids Therethrough and Accompanying Method - A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. | 06-14-2012 |
20120127029 | CODED FILTER - A method and apparatus for estimating and compensating for a broad class of non-Gaussian sensor and process noise. In one example, a coded filter combines a dynamic state estimator (for example, a Kalman filter) and a non-linear estimator to provide approximations of the non-Gaussian process and sensor noise associated with a dynamic system. These approximations are used by the dynamic state estimator to correct sensor measurements or to alter the dynamic model governing evolution of the system state. Examples of coded filters leverage compressive sensing techniques in combination with error models based on concepts of compressibility and the application of efficient convex optimization processes. | 05-24-2012 |
20120118811 | SYSTEMS, METHODS AND DEVICES RELATING TO A CELLULARIZED NEPHRON UNIT - The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them. | 05-17-2012 |
20120082393 | ATTITUDE ESTIMATION WITH COMPRESSIVE SAMPLING OF STARFIELD DATA - In general, in one embodiment, a starfield image as seen by an object is analyzed. Compressive samples are taken of the starfield image and, in the compressed domain, processed to remove noise. Stars in the starfield image are identified and used to determine an attitude of the object. | 04-05-2012 |
20120082345 | ATTITUDE ESTIMATION IN COMPRESSED DOMAIN - In general, in one embodiment, a starfield image as seen by an object is analyzed. Compressive samples are taken of the starfield image and, in the compressed domain, processed to remove noise. Stars in the starfield image are identified and used to determine an attitude of the object. | 04-05-2012 |
20120082338 | ATTITUDE ESTIMATION BY REDUCING NOISE WITH DRAGBACK - In general, in one embodiment, a starfield image as seen by an object is analyzed. Compressive samples are taken of the starfield image and, in the compressed domain, processed to remove noise. Stars in the starfield image are identified and used to determine an attitude of the object. | 04-05-2012 |
20120071792 | PHYSIOLOGICAL AND BEHAVIORAL SENSORS AND METHODS - In various embodiments, a physiological or behavioral signal is derived from a vertical force resulting from the entire weight of a subject. | 03-22-2012 |
20120068801 | FLUIDIC CONSTRUCTS FOR ELECTRONIC DEVICES - In various embodiments, an inductance of an inductor is tuned by adjusting a position of a conductor and/or a magnetic material with respect to a conducting wire of the inductor, thereby changing the electro-magnetic characteristics of the conducting wire. The conductor and/or magnetic material can be disposed in a microfluidic channel and can be moved within the microfluidic channel using a suitable actuator mechanism. | 03-22-2012 |
20120065518 | SYSTEMS AND METHODS FOR MULTILAYER IMAGING AND RETINAL INJURY ANALYSIS - Systems and methods are provided for imaging an eye and identifying retinal or subretinal features that may be indicative of pathologies such as macular degeneration and traumatic brain injury. An infrared or near-infrared image of an eye is interdependently smoothed and segmented and attributes of the image are determined. The attributes are indicative of retinal or subretinal features. | 03-15-2012 |
20110206262 | IMAGE-BASED METHODS FOR MEASURING GLOBAL NUCLEAR PATTERNS AS EPIGENETIC MARKERS OF CELL DIFFERENTIATION - The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell colonies, individual cells, and/or cellular structures. | 08-25-2011 |
20110189770 | Endosome-Disrupting Compositions and Conjugates - The present invention is directed to an endosome-disrupting conjugate, and methods of delivery of said conjugate to cells. The conjugates of the invention comprise a payload and an endosome-disrupting component of which the latter comprises a plurality of moieties that react under acidic conditions, e.g., within an endosome, to release gaseous endosome-disrupting molecules, e.g., CO | 08-04-2011 |
20110188728 | METHODS OF GENERATING TROPHECTODERM AND NEURECTODERM FROM HUMAN EMBRYONIC STEM CELLS - Methods for inducing differentiation of stem cells into trophectoderm, neurectoderm, or progeny cells thereof are described, and mathematical and statistical image analysis methods and systems, for example, to identify differentiated cells and screen for agents which modulate differentiation are provided for separate or combined use. | 08-04-2011 |
20110132088 | FLEXURE ASSEMBLIES AND METHODS FOR MANUFACTURING AND USING THE SAME - In one embodiment, an accelerometer includes a suspension frame, a proof mass, and a plurality of flexures suspending the proof mass from the suspension frame. The flexures allow the proof mass to deflect in response to an acceleration along a sensitive axis of the accelerometer. Each flexure exhibits an initial spring rate along the sensitive axis of substantially zero. | 06-09-2011 |
20110110577 | MATHEMATICAL IMAGE ANALYSIS BASED CELL REPROGRAMMING WITH APPLICATIONS FOR EPIGENETIC AND NON-EPIGENETIC BASE INDUCED PLURIPOTENT STEM CELL DERIVATION - Mathematical and statistical image analysis methods and systems are applied to enhance and refine the process of reprogramming cells, for example, to modify cells from patients into custom-matched stem cells. | 05-12-2011 |
20110102801 | DETERMINING AND COMPENSATING FOR MODULATOR DYNAMICS IN INTERFEROMETRIC FIBER-OPTIC GYROSCOPES - Determining linear modulator dynamics in an interferometric fiber-optic gyroscope may be accomplished by applying a stimulus at a point within the gyroscope, observing a response in an output of the gyroscope, and determining, from the observed response, the linear modulator dynamics. | 05-05-2011 |
20110082563 | MICROSCALE MULTIPLE-FLUID-STREAM BIOREACTOR FOR CELL CULTURE - Microfluidic bioreactor devices may feature intercommunicating microchannels defined in two polymer layers separated by a membrane. A geometric parameter associated with the microchannels in one layer may vary along a length of those channels. | 04-07-2011 |
20110047776 | METHODS AND APPARATUS FOR MOUNTING A CRYSTAL - In various embodiments, a crystal is inserted within a flexible membrane through an opening formed by manipulation of the membrane. | 03-03-2011 |
20110024346 | SYSTEMS, METHODS AND DEVICES RELATING TO A CELLULARIZED NEPHRON UNIT - The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them. | 02-03-2011 |
20100250031 | PROPULSIVE GUIDANCE FOR ATMOSPHERIC SKIP ENTRY TRAJECTORIES - The invention set forth herein describes propulsive guidance methods and apparatus for controlling and shaping an atmospheric skip reentry trajectory for a space vehicle. Embodiments of the invention may utilize a powered explicit guidance algorithm to provide a closed-loop control method for controlling a space vehicle during a skip reentry maneuver. | 09-30-2010 |
20100221188 | Coated sensors and methods related thereto - The invention provides coated sensors for detecting the presence of analytes. The sensor comprises one or more fluorescent sources, such as one or more quantum dots or one or more fluorescent dyes, a polymeric matrix, a surface coating, and one or more analyte sensing components. The surface coating may be a conformal polymeric film, permeable to the analyte, which may be deposited via a solventless process such as initiated chemical vapor deposition or photoinitiated chemical vapor deposition. The surface coating may increase the biocompatibility of the sensor, reduce nonspecific protein adsorption, and/or sequester functional sensor components within the sensor. The invention also provides methods for detecting the presence of an analyte with coated sensors of the invention. | 09-02-2010 |
20100116657 | METHOD AND APPARATUS FOR CONCENTRATING MOLECULES - A method and apparatus for continuously separating or concentrating molecules that includes flowing two fluids in laminar flow through an electrical field and capturing at one of three outputs a fluid stream having a different concentration of molecules. | 05-13-2010 |
20100105075 | SYSTEMS AND METHODS OF VOLTAGE-GATED ION CHANNEL ASSAYS - Systems and methods are provided for optically measuring ion concentrations in biological samples. The systems and methods employ polymer-based optical ion sensors that include ion-selective ionophores and a pH sensitive chromionophore. Electrodes are providing for electrically stimulating the biological samples. | 04-29-2010 |
20100067085 | SYSTEMS, METHODS AND DEVICES FOR ACTUATING A MOVEABLE MINIATURE PLATFORM - Presented herein are systems, methods and devices relating to miniature actuatable platform systems. According to one embodiment, the systems, methods, and devices relate to controllably actuated miniature platform assemblies including a miniature mirror. | 03-18-2010 |
20100002929 | Image-based methods for measuring global nuclear patterns as epigenetic markers of cell differentiation - The invention provides methods for determining the differentiation state of cells. The methods include non-invasive, non-perturbing, automatable, and quantitative methods of analysis of cell colonies, individual cells, and/or cellular structures. | 01-07-2010 |
20090317233 | ROTARY NANOTUBE BEARING STRUCTURE AND METHODS FOR MANUFACTURING AND USING THE SAME - In one embodiment, a rotary device includes a multiwall nanotube that extends substantially perpendicularly from a substrate. A rotor may be coupled to an outer wall of the multiwall nanotube, be spaced apart from the substrate, and be free to rotate around an elongate axis of the multiwall nanotube. | 12-24-2009 |
20090259885 | Systems and methods for redundancy management in fault tolerant computing - Systems and methods for redundancy management in fault tolerant computing are provided. The systems and methods generally relate to enabling the use of non-custom, off-the-shelf components and tools to provide redundant fault tolerant computing. The various embodiments described herein, generally speaking, use a decrementer register in a general purpose processor for synchronizing identical operations across redundant general purpose processors, execute redundancy management services in the kernels of commercial off-the-shelf real-time operating systems (RTOS) running on the general purpose processors, and use soft coded tables to schedule operations and assign redundancy management parameters across the general purpose processors. | 10-15-2009 |
20090201510 | DETERMINING AND COMPENSATING FOR MODULATOR DYNAMICS IN INTERFEROMETRIC FIBER-OPTIC GYROSCOPES - Determining linear modulator dynamics in an interferometric fiber-optic gyroscope may be accomplished by applying a stimulus at a point within the gyroscope, observing a response in an output of the gyroscope, and determining, from the observed response, the linear modulator dynamics. | 08-13-2009 |
20090155183 | Sensors for the detection of diols and carbohydrates - The systems and methods disclosed herein include a sensor particle for detecting the presence of a chelatable analyte, such as glucose, wherein the sensor comprises a chromophore and a fluorescent component, such as a quantum dot. The sensor particle further comprises moieties that bind both a clelatable analyte and chromophore reversibly and competitively. In the presence of the chelatable analyte, the moieties bind the analyte, and release the chromophore. The chromophore absorbs photons of one wavelength in a free state but of a different wavelength in a bound state, and is selected to operate with the fluorescent component such that the chromophore absorbs emissions of the fluorescent substance in only one of the bound and unbound states. In certain aspects, the invention comprises methods for detecting the presence of a chelatable analyte in a medium such as water, blood plasma and urine, using the sensor particles of the invention. | 06-18-2009 |
20090142274 | Intracellular nanosensors and methods for their introduction into cells - The invention provides ion-selective sensors capable of selectively measuring ions, e.g., Na | 06-04-2009 |
20080237044 | Method and apparatus for concentrating molecules - A method and apparatus for continuously separating or concentrating molecules that includes flowing two fluids in laminar flow through an electrical field and capturing at one of three outputs a fluid stream having a different concentration of molecules. | 10-02-2008 |