Prognosys Biosciences, Inc.
|Prognosys Biosciences, Inc. Patent applications|
|Patent application number||Title||Published|
|20160138091||METHODS AND SYSTEMS FOR DETERMINING SPATIAL PATTERNS OF BIOLOGICAL TARGETS IN A SAMPLE - The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.||05-19-2016|
|20160025726||METHODS FOR DETECTING PEPTIDE/MHC/TCR BINDING - Provided herein are compositions and methods for detecting the binding of a peptide to an MHC molecule, and the binding of a peptide: MHC complex to a TCR. In preferred embodiments, the compositions and methods are in a highly-multiplexed way. The compositions and methods disclosed herein can be used to provide direct information on which peptides are bound to an MHC molecule. Also provided is a method for simultaneously detecting a large number of peptides for binding to an MHC molecule and/or a T cell. A method for detecting competitive binding of a large number of peptides to an MHC molecule and/or a T cell is also disclosed. Also provided herein is a method for simultaneously detecting a large number of specific TCRs. The compositions and methods of the present invention are useful for vaccine design, research and monitoring of autoimmune and infectious disease, immunogenicity testing of therapeutics, and tissue typing.||01-28-2016|
|20130109595||METHODS FOR MANUFACTURING MOLECULAR ARRAYS||05-02-2013|
|20130096033||METHODS FOR MANUFACTURING MOLECULAR ARRAYS - The methods of the present invention provide methods for manufacturing a master substrate and methods for manufacturing replica arrays from the master substrate. The methods may be used, for example, directly to manufacture or “print” peptide arrays from a DNA array; however, the methods are applicable to a wide range of manufacturing applications for use any time multiple copies of an array needs to be printed.||04-18-2013|
|20120270748||PEPTIDE DISPLAY ARRAYS - The present invention provides arrays, methods of constructing arrays, and methods of use of such arrays. The arrays of the invention comprise a substrate with two or more discrete constructs or discrete sets of constructs associated on the surface of the substrate, optionally via a linker molecule. The constructs include an oligonucleotide comprising a region encoding a peptide of interest and an affinity tag and an untranslated region, a fusion peptide comprising both the peptide of interest and the affinity tag and a capture agent that forms a binding pair with the affinity tag.||10-25-2012|
|20120258871||PEPTIDE CONSTRUCTS AND ASSAY SYSTEMS - The present invention provides methods for constructing peptide construct sets and methods of use of these peptide construct sets in assay systems for peptide analysis, and in particular for use in high throughput peptide analysis. The methods allow for analysis of large sets of peptide constructs in a cost-effective manner, employing molecular biological techniques that are both robust and easily parallelized. Thus, the methods allow for the construction of peptide construct sets encompassing, e.g., the human proteome.||10-11-2012|
|20120246324||LOAD CHARACTERISTIC ESTIMATION SYSTEM, LOAD CHARACTERISTIC ESTIMATION METHOD, AND PROGRAM - A load characteristic estimation system includes: a program input unit into which a program that runs on a prescribed computer system is inputted; a program feature information acquisition unit that obtains features from the inputted program; and a load characteristic estimation unit that estimates a load characteristic of the inputted program by reading load characteristic information of another program having a feature similar to the inputted program, from a load characteristic recording unit that records a load characteristic produced in the prescribed computer system when the other program was run on the computer system in the past.||09-27-2012|
|20120129248||ASSAY TOOLS AND METHODS OF USE - The present invention provides assay tools for the detection of biological or chemical activity in a sample. The assay tools of the invention provide direct detection using a positive signal generated on a surface of the assay tool. These assay tools provide improved methods for detection and/or identification of multiple agents (e.g., enzymes) in a sample, analysis of substrate specificity of such agents, and binding affinities and specificities of such agents. Upon activity a component is released from a first immobilised construct and then captured by a capture surface. At least two different immobilised constructs are used.||05-24-2012|
|20110245111||SPATIALLY ENCODED BIOLOGICAL ASSAYS - The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.||10-06-2011|
|20110245101||CO-LOCALIZATION AFFINITY ASSAYS - The invention provides a new assay format for high throughput molecular binding studies at a single molecule level. The invention enables creation of binding event identifiers in a highly parallel way. Individual binding events occur between two agents of a binding pair, e.g., a protein-based binding pair or a binding pair comprising a protein and a chemical moiety. The binding event identifier created through the binding of the two binding agents is unique to that pair, and identification of the binding event identifier is indicative of the binding of these specific may be assessed through a readout that is digital in nature. The invention enables very large sets of thousands or more of different binding agents or potential binding agents to be assayed simultaneously, resolving millions or more of potential interactions, and distinguishing specific interactions from those that are less specific.||10-06-2011|
Patent applications by Prognosys Biosciences, Inc.