| Myriad Genetics, Incorporated Patent applications |
| Patent application number | Title | Published |
|---|
| 20140302494 | METHOD OF ANALYZING A BRCA2 GENE IN A HUMAN SUBJECT - Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2 | 10-09-2014 |
| 20140113310 | CANCER DETECTION MARKERS - Methods and compositions involving molecular markers for the detection and characterization of cancer in a patient are provided. | 04-24-2014 |
| 20130280703 | METHOD OF ANALYZING A BRCA2 GENE IN A HUMAN SUBJECT - Five novel DNA and protein sequences have been determined for the BRCA2 gene, as have been ten polymorphic sites and their rates of occurrence in the normal alleles of BRCA2. The sequences BRCA2 | 10-24-2013 |
| 20130143747 | METHODS OF DETECTING CANCER - Methods and compositions involving molecular markers for the detection and characterization of cancer in a patient are provided. | 06-06-2013 |
| 20130079423 | DIAGNOSTIC METHODS INVOLVING LOSS OF HETEROZYGOSITY - The invention relates generally to methods of molecular analysis and particularly to methods of using genetic copy number variations and loss of heterozygosity in the characterization and treatment of disease. | 03-28-2013 |
| 20130058924 | HYPOXIA-RELATED GENE SIGNATURES FOR CANCER CLASSIFICATION - Biomarkers, particularly hypoxia-related genes, and methods using the biomarkers for molecular detection and classification of disease are provided. | 03-07-2013 |
| 20130005610 | TOXICITY-ASSOCIATED GENES, GENETIC VARIANTS, AND USE THEREOF - Genes and genetic variants in human genomes are disclosed which are useful, inter alia, as diagnostic biomarkers. | 01-03-2013 |
| 20120315631 | TUMOR SUPPRESSOR DESIGNATED TS10Q23.3 - A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed. | 12-13-2012 |
| 20120309018 | CANCER DETECTION MARKERS - Methods and compositions involving molecular markers for the detection and characterization of cancer in a patient are provided. | 12-06-2012 |
| 20120041274 | CANCER BIOMARKERS - Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided. | 02-16-2012 |
| 20120015050 | METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY - This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided. | 01-19-2012 |
| 20110311972 | DPYD GENE VARIANTS AND USE THEREOF - Variants in DPYD gene are disclosed which can result in abnormal synthesis of DPD proteins and alteration of DPD activities. The invention provides methods for detecting the newly discovered genetic variants. The DPD genetic variants of the invention can be used as biomarkers in predicting toxicity to 5-FU and other drugs metabolized by the DPD enzyme. | 12-22-2011 |
| 20110144069 | COMPOUNDS FOR TREATING VIRAL INFECTIONS - The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection. | 06-16-2011 |
| 20110076248 | IMMUNIZING COMPOSITIONS COMPRISING HIV-1 PROVIRAL CONSTRUCTS WITH AN INACTIVE P6 GAG TSG101 UEV BINDING DOMAIN CAPABLE OF PRODUCING BUDDING-DEFECTIVE VIRAL PARTICLES THAT REMAIN TETHERED TO THE CELL SURFACE. - The present invention provides methods for preventing and treating HIV infection and AIDS by introducing cells displaying HIV late-domain phenotype into a patient, or by administering to a patient nucleic acids, polypeptides or small organic compounds to cause the formation of cells displaying HIV late-domain phenotype in the body of the patient. | 03-31-2011 |
| 20110034488 | METHOD OF ASSAYING 5-FU - The present invention provides methods, compositions, devices and kits for assaying 5-FU. | 02-10-2011 |
| 20100190176 | TUMOR SUPPRESSOR DESIGNATED TS10Q23.3 - A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed. | 07-29-2010 |
| 20100035261 | METHOD OF DETECTING LARGE GENOMIC REARRANGEMENTS - A method for detecting large genomic rearrangements is disclosed, which is particularly useful in detecting deletions and duplications in the large genes such as BRCA1, BRCA2, MLH1 and MSH2. | 02-11-2010 |
| 20100016586 | THERAPEUTIC COMPOUNDS AND THEIR USE IN CANCER - The invention relates to compounds of Formulae I-III and their therapeutic uses. | 01-21-2010 |
| 20090280133 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF - Disclosed are compounds of Formula I effective as cytotoxic agents. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs. | 11-12-2009 |
| 20090275583 | ANTIVIRAL COMPOUNDS AND USE THEREOF - The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection. | 11-05-2009 |
| 20090253943 | BIRCH BARK PELLETIZATION AND METHODS FOR OBTAINING NATURAL PRODUCTS FROM BIRCH BARK PELLETS - The present invention provides birch bark pellets that include outer birch bark. The present invention also provides methods of manufacturing birch bark pellets from outer birch bark. The present invention also provides methods for obtaining a natural product from birch bark pellets. The birch bark pellets are manufactured from outer birch bark that includes relatively low amounts of inner birch bark and wood. The birch bark pellets meet the requirement for extraction, to obtain e.g., betulin and/or lupeol from the pellets. | 10-08-2009 |
| 20090253768 | THERAPEUTIC COMPOUNDS FOR DISEASES AND DISORDERS - Pyrrole derivatives are disclosed as agents for the treatment and prevention of neuropathies and neurodegenerative diseases characterized by the presence of axonal blockages, impaired axonal transport or impaired trafficking of vesicles in neurons. | 10-08-2009 |
| 20090155903 | PHARMACEUTICAL COMPOSITION AND METHOD - The invention provides compounds, pharmaceutical compositions and methods for the therapeutic treatment and prevention of neurodegenerative disorder and other Aβ | 06-18-2009 |
| 20090149429 | ANTIVIRAL COMPOUNDS - The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection. | 06-11-2009 |
| 20090105203 | COMPOUNDS FOR TREATING VIRAL INFECTIONS - The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection. | 04-23-2009 |
| 20090099179 | COMPOUNDS FOR DISEASES AND DISORDERS - The invention provides novel compounds useful for the treatment of disorders associated with a defect in vesicular transport (e.g., axonal transport). The compounds have a substituents chosen from -L-C(═O)OH, -L-CH═CHC(═O)OH, -L-C(═O)NH | 04-16-2009 |
| 20090087436 | COMPOSITIONS AND METHODS FOR TREATING DISEASES - Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members. | 04-02-2009 |
| 20090082265 | COMPOSITIONS AND METHODS FOR TREATING DISEASES - Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members. | 03-26-2009 |
| 20090069350 | PHARMACEUTICAL COMPOSITIONS AND USE THEREOF - The present invention relates to pharmaceutical compositions and dosage compositions of compounds, including injectable formulations for the parenteral delivery of such compounds into patients in need of such treatment. Also featured are methods of making and using the compositions, including methods for the treatment of neoplastic diseases. | 03-12-2009 |
| 20090062229 | METHOD AND COMPOSITION FOR REDUCING THE EXPRESSION OF ROCK-II - Methods and compositions for reducing the expression of Rho-associated, coiled-coil containing protein kinase 2 (ROCK-II) are provided. | 03-05-2009 |
| 20090048346 | THERAPEUTIC FORMULATIONS - The present invention features pharmaceutical compositions that improve the bioavailability of hydrophobic pharmaceutical agents that induce apoptosis in mammalian cells. Also featured are injectable formulations for the parenteral delivery of such hydrophobic pharmaceutical agents into patients in need of such treatment, as well as methods of making and using both the compositions and formulations, including methods for the treatment of cell proliferation or hyperproliferative diseases and disorders. | 02-19-2009 |
| 20090048111 | RNA INTERFERENCE USING A UNIVERSAL TARGET - The present invention provides novel methods for manipulating levels of expression of gene products using RNA interference (RNAi). The methods disclosed can be used to investigate gene function, to create disease-resistant organisms, and to treat disease. | 02-19-2009 |
| 20090035853 | TSG101-GAG INTERACTION AND USE THEREOF - Isolated protein complexes are provided comprising Tsg101 and HIV GAG or GAGp6. The protein complexes are useful in screening assays for selecting compounds effective in modulating the Tsg101-HIV GAG or GAGp6 interaction within the protein complexes. | 02-05-2009 |
| 20090029362 | GENE COPY NUMBER PROFILING - The invention relates to copy number profile analysis. Specifically, copy number profile analysis is used to determine whether two or more separate tumors in a single individual are derived from a common source. | 01-29-2009 |
| 20080318224 | LARGE DELETIONS IN HUMAN BRCA1 GENE AND USE THEREOF - Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to cancer. | 12-25-2008 |
| 20080318223 | LARGE DELETIONS IN HUMAN BRCA1 GENE AND USE THEREOF - Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to cancer. | 12-25-2008 |
| 20080286827 | BIOMARKERS - The invention relates to biomarkers for use in diagnosing cancer and in classifying tumors. | 11-20-2008 |
| 20080261231 | DIABETES GENE - The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect human diabetes mellitus predisposing gene, specifically the angiotensinogen (AGT) gene, some mutant alleles of which cause susceptibility to insulin-dependent diabetes mellitus (IDDM). More specifically, the invention relates to germline mutations in the AGT gene and their use in the diagnosis of predisposition to diabetes. The invention also relates to the prophylaxis and/or therapy of diabetes associated with a mutation in the AGT gene. The invention further relates to the screening of drugs for diabetes therapy. Finally, the invention relates to the screening of the AGT gene for mutations, which are useful for diagnosing the predisposition to diabetes. | 10-23-2008 |
| 20080249158 | PYRROLE DERIVATIVES AS THERAPEUTIC COMPOUNDS - Novel pyrrole derivatives are disclosed as Aβ | 10-09-2008 |
| 20080249135 | COMPOUNDS FOR ALZHEIMER'S DISEASE - The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(═O)OH, -L-CH═CHC(═O)OH, -L-C(═O)NH | 10-09-2008 |
| 20080207573 | COMPOUNDS FOR TREATING VIRAL INFECTIONS - The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection. | 08-28-2008 |
