Merck Sharpe & Dohme Corp. Patent applications |
Patent application number | Title | Published |
20140343053 | TRIAZOLOPYRIDINONE PDE10 INHIBITORS - The present invention is directed to triazolopyridinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction. | 11-20-2014 |
20130316398 | EFFICIENT PRODUCTION OF HETEROLOGOUS PROTEINS USING MANNOSYL TRANSFERASE INHIBITORS - Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation. | 11-28-2013 |
20130039916 | ENGINEERED ANTI-IL-23p19 ANTIBODIES - Engineered antibodies to human IL-23p19 are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders. | 02-14-2013 |
20130011875 | METHODS FOR THE PRODUCTION OF RECOMBINANT PROTEINS WITH IMPROVED SECRETION EFFICIENCIES - The present invention is related to methods and for producing higher titers of recombinant protein in a modified yeast host cell, for example | 01-10-2013 |
20120231502 | METHOD FOR PRODUCING THERAPEUTIC PROTEINS IN PICHIA PASTORIS LACKING DIPEPTIDYL AMINOPEPTIDASE ACTIVITY - The present invention related to methods and compositions for producing therapeutic proteins in yeast cell lines, and in particular | 09-13-2012 |
20120149674 | Diaryl Substituted Alkanes - The instant invention provides compounds of Formula II which are 5-lipoxygenase activating protein inhibitors. | 06-14-2012 |