LYNNTECH, INC. Patent applications |
Patent application number | Title | Published |
20130053541 | METHODS FOR DISCOVERING MOLECULES THAT BIND TO PROTEINS - Methods and systems for the discovery of high-affinity peptide ligands and the resulting compositions are described herein. The amino acid sequence of a target protein is used to identify one or more homologous proteins of the target protein. Publications and databases are textmined to retrieve the sequences of peptide ligands that bind to the homologues or the target protein. Complementary proteins, which are proteins that bind to the target or homologous proteins or to DNA, and their target protein- or DNA-binding regions may also be identified. These candidate ligands are predicted to have a high probability of binding to the target protein or the DNA. The library of candidate peptide ligands is modulated by substituting native amino acid residues with suitable amino acids, thus increasing the explored protein space in a knowledge-based manner. Peptides designed in the modulation step are experimentally screened to identify high-affinity binding ligands, and further optimized through iterative application of the modulation and screening steps. | 02-28-2013 |
20120264802 | PHOTOSENSITIZERS FOR TARGETED PHOTODYNAMIC THERAPY - The present invention relates to photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof. | 10-18-2012 |
20110253604 | OZONATION SYSTEM FOR TREATING SECONDARY WASTEWATER - Septic systems incorporating an ozonation system comprise one or more corona discharge ozone generators receiving air, such as atmospheric air, and having an outlet for the withdrawal of a mixture of air and ozone gas. The system also comprises a septic tank for receiving primary wastewater, and a pump tank receiving secondary wastewater effluent from the septic tank. The ozonation system includes a submersible ozone introduction pump disposed in the bottom of the pump tank, wherein the ozone introduction pump includes an impeller within a housing, the housing having an inlet and a plurality of radial outlet ports along its circumferential area surrounding the impeller. A conduit couples the outlet of the corona discharge ozone generator to the inlet of the impeller housing, wherein the ozone introduction pump reduces pressure in the conduit to draw air into the ozone generator and draws the mixture of air and ozone gas into the impeller housing for introduction into the secondary wastewater. An optional ultraviolet light source may be disposed in the headspace of the pump tank to enhance the activity of the ozone. | 10-20-2011 |
20100184818 | PHOTOSENSITIZERS FOR TARGETED PHOTODYNAMIC THERAPY - The present invention provides photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof. | 07-22-2010 |
20100158646 | Method and Apparatus for Handling Magnetic Particles - Method, apparatus and system for controllably conveying magnetic particles between closed chambers. Magnetic particles are magnetically attracted from a first solution-containing chamber into a motive cavity, such as may be formed in a rotor of a pump. The magnetic particle-containing motive cavity is then moved out of fluid communication with the first solution-filled chamber and moved into fluid communication with a second solution-filled chamber. Finally, the magnetic particles are magnetically releasing from the motive cavity into the second solution-containing chamber. The first and second chambers are preferably never in direct fluid communication. Because the rotor is sealed with the pump body and there is no direct fluid communication between the first and second chamber, contact between the first solution and the second solution is limited by the size of the motive cavity. Optionally, the particles are magnetically attracted by temporarily inserting a magnet into a rotor. This method has significant advantages over existing magnetic particle manipulation systems because it can be utilized as a closed system with a very innovative and low-cost approach. | 06-24-2010 |
20100053605 | GAS SAMPLING DEVICE AND METHOD FOR COLLECTION AND IN-SITU SPECTROSCOPIC INTERROGATION OF VAPORS AND AEROSOLS - A gas sampling device, analyte detection system, and methods for identifying a vapor or aerosol analyte suspended in a gas are described. The gas sampling device comprises a chamber having a gas inlet port, a substrate, one or more gas outlet ports near the substrate, and a pump. The gas outlet ports direct airflow to a reflecting substrate coated with a spectroscopically-transparent material. Analytes are deposited on the coated substrate through impaction, for massive aerosols, and diffusion through the viscous boundary layer, for vapor analytes. In one analyte detection system, a spectroscopic instrument is positioned behind a window opposite the substrate to interrogate the coated substrate surface as analytes are collected. An alternate detection system combines the gas sampling device with a detector in fluid communication with the gas outlet ports from the chamber, wherein the substrate is used as an analyte concentrator. | 03-04-2010 |
20100021778 | FUEL CELL EMERGENCY POWER SYSTEM - Fuel cell emergency power systems comprising a fuel cell having an anode and a cathode, a power distribution unit for selectively directing electrical current from the fuel cell to one or more consuming device, a hydrogen gas control system and an oxygen gas control system. The hydrogen gas control system includes a pressurized hydrogen tank providing hydrogen gas in selective fluid communication to the anode, a hydrogen gas-liquid water phase separator in downstream fluid communication with the anode, and a hydrogen recirculation pump for recirculating substantially liquid water-free hydrogen from the hydrogen gas-liquid water phase separator to the anode. Similarly, the oxygen gas control system includes a pressurized oxygen tank providing oxygen gas in selective fluid communication to the anode, an oxygen gas-liquid water phase separator in downstream fluid communication with the anode, and an oxygen recirculation pump for recirculating substantially liquid water-free oxygen from the oxygen gas-liquid water phase separator to the anode. | 01-28-2010 |
20090321636 | METHOD OF SEARCHING FOR A THERMAL TARGET - In one embodiment, an efficient method is presented for aerial searching for a small thermal target in a search area, such as a single person in open water, using two thermal imagers or “cameras” coupled with a computer which presents data from the system to a human user for inspection. One of the two thermal imagers has a very wide field of view (WFOV) fixed forward of or below the aircraft. The other, narrow field-of-view (NFOV) imager has a high zoom capability but its field of view can be reoriented to geo-point to a location on command. The WFOV thermal imager collects images rapidly so that no individual image is blurred due to changes in the field of view (FOV) on the time-scale of the image capture. The images are geo-registered using information from a global positioning receiver as well as the current altitude, roll, pitch, yaw, and velocity of the aircraft. As the aircraft moves and the FOV in the WFOV thermal imager changes, the computer averages the amplitude of the thermal radiation detected from each geo-registered position on the water below using the captured images continuously and in real time. The signal from a thermal target in the water is integrated while the background is relatively suppressed, enhancing the signal-to-noise ratio for the target as the square root of the number of images collected in which the target appears. A target which is much smaller than the area covered by a single pixel or that even has a thermal contrast below the noise equivalent temperature difference of the WFOV thermal imager can be detected. Thermal anomalies which have a signal commensurate in amplitude and spatial extent to the object of the search are selected by the system and their coordinates are relayed to the NFOV thermal imager. The NFOV thermal imager zooms into these locations sequentially and presents the image information to the human user who can then either reject or verify that the subject being imaged is the object of the search. | 12-31-2009 |
20090076115 | Photosensitizers for Targeted Photodynamic Therapy - The present invention relates to photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof. | 03-19-2009 |
20090071838 | ELECTROCHEMICAL APPARATUS WITH RETRACTABLE ELECTRODE - Electrochemical apparatus and methods that support periodic, non-steady state, or discontinuous operation without suffering degradation of materials or loss of efficiency. The invention provides a means for positioning one or more electrodes into contact with electrolyte and means for retracting the one or more electrodes out of contact with the electrolyte. The means for positioning and means for retracting may be the same device or different devices. The means for positioning and means for retracting may be designed to provide automatic, passive, or fail-safe retraction of the electrode upon a given shutdown condition, such as a voltage of less than one Volt being applied between the first and second electrodes, expiration of a time period, an ozone concentration greater than a setpoint ozone concentration, contact pressure of less than 5 psig, and combinations thereof. | 03-19-2009 |
20090017549 | Apparatus and Method for Determining The Concentration of Iodine-Containing Organic Compounds in an Aqueous Solution - A method for determining the amount of a known iodine-containing organic compound in an aqueous solution. The method comprises electrochemically reducing the known iodine-containing organic compound in an aqueous medium to release iodide anions, chemically oxidizing the iodide anions to produce molecular iodine, and measuring the amount of molecular iodine. The known iodine-containing organic compound is preferably an aryl iodide, such as Iothalamate. Other preferred iodine-containing organic compounds include various glomerular filtration rate (GFR) marker compounds in plasma or urine samples, as useful in the measurement of GFR for an animal. The electrochemical reduction of the known iodine-containing organic compound is preferably performed in an electrochemical cell including a working electrode separated from a counter electrode by a cation exchange membrane. The working electrode most preferably includes bismuth and the counter electrode most preferably includes platinum. | 01-15-2009 |
20090012204 | FUNCTIONALIZATION OF POLYMERS WITH REACTIVE SPECIES HAVING BOND-STABILIZED DECONTAMINATION ACTIVITY - Functionalized polymers and methods of functionalizing polymers with reactive species having decontaminating activity, such as polyoxometalates and metal oxides. Covalent bonding of the reactive species to the polymer securely immobilizes the reactive species and stabilizes the decontaminating activity of the reactive species. Specifically, the covalent bonding of the reactive species greatly reduces moisture deactivation during prolonged exposure to atmospheric moisture. Polyoxometalates are catalytically reactive through oxidative pathways and metal oxides are reactive through hydrolytic pathways. Both polyoxometalates and metal oxides having oxygen atoms available for covalent bonding with an appropriate bifunctional linking agent. | 01-08-2009 |
20080278708 | NANOCOMPOSITE MATERIAL FOR DIRECT SPECTROSCOPIC DETECTION OF CHEMICAL VAPORS - Method and material for spectroscopic detection of organic chemicals. The material is a substantially optically transparent solid, such as ZnS, having a high surface area for adsorption of an analyte, such as organic chemical vapors. The solid material preferably has metal nanoparticles, such as gold, silver or copper nanoparticles, deposited on the surface for signal enhancement. A template compound, such as cetyl trimethyl ammonium bromide and alkoxylate block polymers, may be used during the material synthesis, such as reacting zinc chloride and sodium sulfide in the presence of the template compound, and later removed through calcination and washing to achieve the high surface area. The method of use includes collecting an analyte on the material and detecting the spectroscopic response of the analyte while it is collected on the surface. The mechanism of collection may include adsorbing, absorbing, and preconcentrating. Preferably, the spectroscopic response is selected from infrared spectra or ultraviolet-visible spectra. | 11-13-2008 |