LEICA BIOSYSTEMS MELBOURNE PTY LTD. Patent applications |
Patent application number | Title | Published |
20150343445 | METHOD OF PRODUCING A REAGENT ON-BOARD AN INSTRUMENT - The present invention relates broadly to production of a reagent on-board an instrument. The instrument is provided with one or more mixing wells | 12-03-2015 |
20150308931 | THERMAL MODULE FOR A SAMPLE PROCESSING ASSEMBLY - A thermal system for controllably altering a temperature within a reaction chamber in a sample processing assembly is described. The reaction chamber is bounded by a substrate and cover member in the sample processing assembly. The thermal system includes at least one thermal generator for generating temperature changes, one or more transfer layers for transferring temperature changes between the thermal generator and the sample on the substrate and a fluid isolator for isolating the thermal generator from fluid dispensed into the reaction chamber. | 10-29-2015 |
20150300931 | SLIDE TRANSPORT SYSTEM - A slide transport system for an automated slide treatment apparatus having slide treatment modules for receiving slides and a fluid dispensing robot configured by a controller to dispense reagents to the slides is disclosed. The slide transport system includes a slide transport robot configured by the controller to move the slides to and from the slide treatment modules and a slide transport device disposed on the slide transport robot and configured by the controller to releasably hold the slides. A slide handling head on the slide transport robot moves a closure body of a slide treatment module from a normally closed to an open position to move slides in the slide treatment module. The slide transport device is configured by the controller to release a slide when located in the slide treatment module, when the closure body is in the open position. | 10-22-2015 |
20150276772 | FLUID TRANSPORT SYSTEM - A fluid transport system for an automated slide treatment apparatus having slide treatment modules is disclosed. The fluid transport system including a fluid dispensing robot configured by a controller to dispense a plurality of reagents to slides received in the slide treatment modules. The fluid dispensing robot includes pumping means configured by the controller to pump the reagents to be dispensed from a plurality of corresponding reagent containers; a probe having a body arranged to store one or more of the reagents pumped via the pumping means so as to prime the probe with said one or more of the reagents to be dispensed; and a well disposed on the body of the probe to store further of the reagents primed to be dispensed. | 10-01-2015 |
20150253225 | SLIDE STAINING ASSEMBLY AND COVER MEMBER - A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided. | 09-10-2015 |
20150224494 | COVER MEMBER WITH ORIENTATION INDICIA - A cover member for use in the treatment of a sample on a substrate is disclosed. The cover member has fluid flow features and is adapted for use in an instrument, such as a laboratory instrument. The cover member comprises at least one orientation feature detectable by the instrument for ascertaining an orientation of the cover member. An automated method for detecting orientation of a cover member in a sample treatment assembly is also disclosed, in which a processor compares data corresponding to one or more images collected from the sample treatment assembly, with data representing a reference image to determine if a cover member is in the sample treatment assembly. | 08-13-2015 |
20140371884 | LABORATORY INSTRUMENT CONTROL SYSTEM - A server computer system connected to a first communications network and including:
| 12-18-2014 |
20140342358 | BIOLOGICAL SAMPLE TREATMENT APPARATUS - Apparatus for treating biological samples disposed on substrates, including: an input buffer for receiving one or more substrate holders each being adapted to support a plurality of the substrates; a treatment zone including a plurality of treatment stations each being adapted to receive one of the substrates; a reagent dispenser configured by a controller to dispense reagents to the substrates at the treatment stations; a substrate transport device configured by the controller to transport individual substrates between the substrate holders in the input buffer and the treatment stations. | 11-20-2014 |
20140329270 | AUTOMATED SYSTEM AND METHOD OF TREATING TISSUE SAMPLES ON SLIDES - An automated method and system for treating one or more tissue samples disposed on slides, the system comprising: a controller, a plurality of slide treatment modules arranged to receive ones of the slides; at least one fluid dispensing robot configured by the controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules via an output nozzle disposed on the at least one fluid dispensing robot to treat said one or more tissue samples respectively; and at least one pumping means for pumping said reagents to the output nozzle of the at least one fluid dispensing robot from a plurality of reagent containers comprising said reagents, wherein the at least one fluid dispensing robot is configured by the controller to dispense said reagents in a predetermined sequence for each of the slide treatment modules to treat the one or more tissue samples disposed on each of the slides independently. | 11-06-2014 |
20140315256 | COVER MEMBER, METHOD AND TREATMENT MODULE FOR TREATING A BIOLOGICAL SAMPLE ON A SUBSTRATE - A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member. | 10-23-2014 |
20130185091 | DEVICE AND METHOD FOR CROSS-REFERENCING - A sample, embedded in a paraffin block, is placed on a tissue cassette which carries a label which may be a bar code. When the sample is processed, the cassette is given to a microtome operator who scans the label. Scanning causes information to be displayed on a screen and the operator verifies that what is on the screen matches what was on the label. The paraffin block is then placed in a microtome chuck and sections are cut from the block. A number of slide labels related to the cassette label are printed for the sections. If the operator does not verify that the information displayed on the screen matches the information on the cassette label and/or does not place the paraffin block in the microtome chuck within an allocated time interval after scanning the cassette label, dispensing and labeling of slides and/or operation of the microtome is prevented. | 07-18-2013 |
20130123979 | BIOLOGICAL REACTION APPARATUS WITH DRAINING MECHANISM - A biological reaction apparatus for receiving at least one substrate having a sample located in a sample region, and a separate cover, such that a reaction chamber is formed between the cover and substrate over the sample region, wherein the apparatus includes a locating means to locate the substrate; a cover locating means for locating and moving the cover with respect to the substrate; a fluid dispensing means for dispensing fluid into the reaction chamber; and a draining mechanism; wherein the draining mechanism includes wicking means. | 05-16-2013 |
20130078734 | MICROSCOPE SLIDE COVER WITH INTEGRATED RESERVOIR - A cover for a substrate including: a body defining a cavity, for positioning over the substrate to form a reaction chamber; and a projection extending from the body to define a fluid reservoir, when the cover is fitted to the substrate, the fluid reservoir being in fluid communication with the cavity. | 03-28-2013 |
20120208287 | REAGENT SYSTEM AND METHOD - The present invention relates generally to a chromogenic compositions and reagents systems and methods therefor. | 08-16-2012 |
20110201106 | DEVICES AND METHODS FOR TISSUE HANDLING AND EMBEDDING - A mould and tissue cassette for automated embedding of tissue, and a method of operation are disclosed. The mould attaches to the cassette prior to embedding, and fits into a rack. The rack supports the mould holding the tissue cassette when the mould and cassette are in a first position. When the mould and cassette are moved to a second position, a projection on the rack separates the mould from the cassette, to facilitate easy removal. Also disclosed is a mould for a tissue cassette having projections for holding the mould to a rack, so that the tissue cassette is not in contact with the mould. | 08-18-2011 |
20110174088 | IN STAINING INSTRUMENTS AND METHODS - An apparatus and method for applying reagents to tissue mounted on slides, in the field of histology is disclosed. The apparatus holds a number of slides, in slide trays, which are loaded onto the apparatus. Each slide tray forms a batch of slides, with all the batched forming a group. The apparatus holds a number of reagents, grouped into a first group comprising bulk type reagents, and a second group comprising antibodies or probes, and detection systems, for identifying elements of the tissue. A group fluid dispenser, in the form of a robot arm, dispense reagents to the group of slides. Each batch of slides has its own batch fluid dispenser to dispense reagents onto the batch of slides. In on embodiment, the group fluid dispenser dispense antibodies, probes, detection reagents to all slides depending on the protocol defined for each slide, and the batch dispensers dispense bulk reagent to each batch, thus freeing the group fluid dispense from dispensing bulk reagents to all slides. | 07-21-2011 |
20100151513 | DEVICE AND METHOD FOR TISSUE HANDLING AND EMBEDDING - A tissue embedder comprising a transport mechanism for an input member, the input member adapted to hold a plurality of tissue supports, with each tissue support associated with a mould, a wax bath and a cooling station wherein the transport mechanism moves the input member from a wax bath to a cooling station. | 06-17-2010 |
20090210254 | DEVICE AND METHOD FOR CROSS-REFERENCING - A sample, which is embedded in a paraffin block, is placed on a tissue cassette ( | 08-20-2009 |
20080254504 | Method and Apparatus For Handling Tissue Samples - A tissue handling apparatus is provided comprising a support and a locator, for processing and embedding tissue samples. The support and cover form a chamber, within which a tissue sample is oriented prior to processing. After processing, the tissue sample within the chamber is embedded and the locator is removed, leaving the tissue sample correctly oriented in embedding material, mounted to a support, ready for microtoming. | 10-16-2008 |
20080220468 | HISTOLOGICAL TISSUE SPECIMEN TREATMENT - A tissue processor for processing tissue samples for histological analysis. The processor comprises two retorts, wax baths, reagent containers, a pump and valve. The vale distributes the reagent from one container to either retort. Separate reagent lines connect the wax baths to the retorts. A method of infiltrating a sample containing a reagent such as a dehydrating reagent like an alcohol, where the infiltrating material is heated to a temperature at or above the boiling point of the reagent, to boil off the reagent when the tissue sample is contacted by the infiltrating material. The pressure in the retort may be reduced to lower the boiling point of the reagent. | 09-11-2008 |