KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES Patent applications |
Patent application number | Title | Published |
20160120851 | BENZOTHIAZOLE DERIVATIVES AND A USE THEREOF FOR THE TREATMENT OF CANCER - Provided are a compound represented by Formula I, a pharmaceutically acceptable salt thereof, or a solvate thereof; and a pharmaceutical composition for cancer treatment and a pharmaceutical composition for a radiation sensitizer for cancer treatment, each pharmaceutical composition including the compound of Formula I, the pharmaceutically acceptable salt thereof, or the solvate thereof: | 05-05-2016 |
20160018539 | APPARATUS AND METHOD FOR CALCULATING CORRECTION FACTOR - Provided is an apparatus and method for calculating a correction factor, the apparatus including: a counter configured to acquire first data indicating a counted value of a first radiation source according to an activity and an energy window width, and to acquire second data indicating a coincidence value of a second radiation source according to an activity and an energy window width; and a calculator configured to calculate a correction factor for correcting a difference of the coincidence value of the second radiation source having occurred in response to a single gamma photon emission of the first radiation source, based on the first data and the second data. | 01-21-2016 |
20160016943 | BENZOTHIAZOLE DERIVATIVES AND A USE THEREOF FOR THE TREATMENT OF CANCER - Provided are a compound represented by Formula I, a pharmaceutically acceptable salt thereof, or a solvate thereof; and a pharmaceutical composition for cancer treatment and a pharmaceutical composition for a radiation sensitizer for cancer treatment, each pharmaceutical composition including the compound of Formula I, the pharmaceutically acceptable salt thereof, or the solvate thereof: | 01-21-2016 |
20160003952 | POLYHEDRAL-SHAPED RADIATION COUNTER - Provided is a polyhedral-shaped radiation counter which measures a radiation level of a radioactive material, in which sensor modules configured to measure the radiation level are disposed at vertexes of a polyhedral shape, respectively, and the sensor modules are connected to each other by rod-shaped frame members disposed in edge positions of the polyhedral shape and face parts of the polyhedral shape form an open space. | 01-07-2016 |
20150186424 | APPARATUS AND METHOD OF RESAMPLING EVENT DATA FOR QUANTITATIVE IMPROVEMENT OF PET IMAGE - Provided are apparatuses and methods of resampling event data for quantitative improvement of a PET image, which acquire a quantitatively-improved new PET image by analyzing a storage format of list data prior to conversion into the PET image and nonparametrically resampling event data from the list data based on the analysis results to improve noise and statistical characteristics thereof. The quantitatively improved new PET image may be acquired by analyzing a storage format of list data constituting the PET image and nonparametrically resampling event data to improve noise and statistical characteristics thereof. | 07-02-2015 |
20150185338 | APPARATUS AND METHOD OF DETERMINING OPTIMAL ENERGY WINDOW FOR OPTIMAL POSITRON EMISSION TOMOGRAPHY - An apparatus and method for determining an optimal energy window for optimal positron emission tomography (PET) is disclosed. An optimal energy window determining apparatus may include a data corrector configured to correct data measured from an image quality phantom, an image quality measurer configured to measure an image quality for the corrected data, and an optimal energy window determiner configured to determine the optimal energy window based on the measured image quality. The data corrector may correct the measured data based on a difference between sensitivities measured using different radiopharmaceuticals in at least one energy window. | 07-02-2015 |
20150141486 | COMPOSITION COMPRISING miRNA FOR ENHANCING RADIATION SENSITIVITY - Provided are a method of enhancing radiation sensitivity by using miR-499b-5p and a method of treating a radiation resistant cancer including administering miR-499b-5p. | 05-21-2015 |
20140357517 | RADIATION EXPOSURE DIAGNOSTIC MARKER IGFBP-5, COMPOSITION FOR RADIATION EXPOSURE DIAGNOSIS BY MEASURING THE EXPRESSION LEVEL OF THE MARKER, RADIATION EXPOSURE DIAGNOSTIC KIT COMPRISING THE COMPOSITION, AND METHOD FOR DIAGNOSING RADIATION EXPOSURE USING THE MARKER - The present disclosure provides a composition for radiation exposure diagnosis including an agent for measuring an expression level of an insulin-like growth factor-binding protein-5 (IGFBP-5) gene at an mRNA or the protein and a kit for radiation exposure diagnosis. Methods of diagnosing radiation exposure as well as methods for screening an agent for enhancing radiation sensitivity or for radiation protection are disclosed. Also provided are compositions for enhancing radiation sensitivity and/or radiation protection. | 12-04-2014 |
20140336439 | PORTABLE PHANTOM DEVICE - A portable phantom device according to the present invention is a phantom device which is detachably installed in a bird cage that is coupled to an irradiator, and includes a body provided with an accommodation space having a cylindrical shape and a top of which is open so as to accommodate water, a horizontality adjustment maintaining portion which is detachably coupled to a side wall of the body; and a sensor holding portion which is installed on the side wall of the body so as not to interfere with the horizontality adjustment maintaining portion, so that a sensor for measuring the amount of radiation that is incident on the accommodation space may be inserted from the outside of the body and accommodated in the body (Representative drawing: FIG. | 11-13-2014 |
20140065109 | USE OF SUBSTANCE P FOR MOBILIZATION OF MESENCHYMAL STEM CELLS OR PROLIFERATION OF MESENCHYMAL STEM CELLS AND FOR WOUND HEALING OR FACILITATING WOUND HEALING - The present invention relates to a use of Substance-P for the manufacture of a medicament for mobilization or proliferation of Mesenchymal stem cells (MSCs) from the bone marrow, or facilitating said mobilization or proliferation, and use of Substance-P for the manufacture of a medicament for wound-healing or facilitating wound-healing. | 03-06-2014 |
20130184336 | PHARMACEUTICAL COMPOSITION FOR SUPPRESSING ANGIOGENESIS, AND METHOD FOR SCREENING ACTIVE MATERIAL FOR SUPPRESSING ANGIOGENESIS - The present invention provides a pharmaceutical composition for suppressing angiogenesis, containing heat shock protein 27 (HSP27) or a nucleic acid encoding HSP27. In addition, the present invention provides a pharmaceutical composition for treating cancer, containing HSP27 or a nucleic acid encoding HSP27. Additionally, the present invention provides a method of suppressing the in vitro growth of endothelial cells using HSP27. Further, the present invention provides a method of screening an active material for suppressing angiogenesis or an active material for treating cancer, comprising the following steps: processing endothelial cell lines into samples, respectively; measuring the content of HSP27 in an endothelial cell line; and selecting the sample in which the content of HSP27 in an endothelial cell line is increased compared with a control group. | 07-18-2013 |
20130149319 | ANTICANCER COMPOSITION - Disclosed is an anticancer composition, comprising an inhibitor against WIG1 and/or YPEL5 or against a protein encoded by the gene. A composition for screening an anticancer agent comprising a nucleic acid having a sequence complementary to an mRNA of WIG1 and/or YPEL5, or an antibody to a protein encoded by the gene is also provided. Also, a method is provided for screening an anticancer agent, which comprises: (A) quantitatively analyzing expression of WIG1 and/or YPEL5 at an mRNA or protein level in a tumor cell which is not treated with a candidate for an anticancer agent; (B) quantitatively analyzing expression of the gene at an mRNA or protein level in a tumor cell after treatment of the candidate for an anticancer agent; and (C) selecting the candidate if the expression level of the gene is increased in step (B), compared to step (A). | 06-13-2013 |
20130085187 | DEACETYLATION HYDROLASE OF HYALURONIC ACID, HYALURONIC ACID DEACETYLATED BY SAME AND DERIVATIVE THEREOF - The present disclosure relates to a deacetylation hydrolase of a hyaluronic acid a hyaluronic acid deacetylated by same and a derivative thereof. The deacetylated hyaluronic acid and the derivative thereof have the following characteristic: a delayed initial decomposition rate on a living body; minimized decrease of molecular weight and viscosity; accelerated gelation due to a lower gelation temperature than the gelation temperature for a non-deacetylated hyaluronic acid; and an hMSC survival rate that is hardly affected by increased concentration of the deacetylated hyaluronic acid and the derivative thereof in a culture medium. As a result, the deacetylated hyaluronic acid and the derivative thereof can be useful as a bioingredient such a delivery system for a cell, gene, drug, and the like, or a support for tissue engineering, etc. | 04-04-2013 |
20130000428 | MULTI-LEAF COLLIMATOR DEVICE FOR RADIOTHERAPY - A multi-leaf collimator device for radiotherapy, including: a frame that has a box shape and has through-holes formed in top and bottom surfaces thereof; a plurality of collimators that are received in the frame, wherein each of the collimators includes a rack gear formed on the top surface of the collimator, the collimators are symmetrically arranged in a left-right direction about a central portion of the frame, and are slidably provided on the frame; and a motion driving unit that includes a pinion gear that is formed to be detachable from the rack gear formed on the top surface of the collimator, and is provided on the frame to move the pinion gear in a front-back direction of the frame and an up-down direction of the frame. | 01-03-2013 |
20120034235 | Marker for Liver-Cancer Diagnosis and Recurrence and Survival Prediction, a Kit Comprising the Same, and Prognosis Prediction in Liver-Cancer Patients Using the Marker - A composition for detecting a marker for the diagnosis or prognosis of liver cancer is disclosed. The composition includes an agent capable of assessing the expression level of UQCRH (ubiquinol-cytochrome c reductase hinge protein). In addition, a kit having the composition, a microarray for the diagnosis of liver cancer using the marker, and a method for detecting the marker, and predicting recurrence following surgery in liver cancer patients are disclosed. The marker is able to contribute to the early diagnosis of liver cancer and prediction of recurrence following surgery and survival of liver cancer patients who have undergone hepatic resection, and also is significant for being a promising therapeutic target for liver cancer. | 02-09-2012 |
20110046086 | Composition Comprising Polysaccharide Extracted from Panax Ginseng Preventing and Treating Liver Diseases - The present disclosure relates to a | 02-24-2011 |
20100304409 | METHOD FOR DETECTING PREMATURE SENESCENCE IN TUMOR CELLS AND A KIT FOR DETECTING PREMATURE SENESCENCE IN TUMOR CELLS - The present invention provides a method for detecting senescence in tumor cells and a kit for detecting senescence in tumor cells. eEF1A1 and CD markers are provided, wherein changes in the levels of the markers are correlated with premature senescence of tumor cells. | 12-02-2010 |
20100294655 | RADIOISOTOPE PRODUCTION O-18 WATER TARGET HAVING IMPROVED COOLING PERFORMANCE - A target apparatus for producing a radioisotope having improved cooling performance including a cavity member including a cavity accommodating H | 11-25-2010 |
20100233758 | Protein increasing cell infectivity of herpes simplex virus and use thereof - Provided are an isolated protein derived from an N-terminal of HveA/HVEM and having activity of increasing the cell infectivity of herpes simplex virus (HSV) and use thereof. | 09-16-2010 |
20100180632 | PILEUS-GILLS TYPE HELIUM CONDENSER AND APPARATUS INCLUDING THE SAME - Provided are a pileus-gills type helium condenser and an apparatus, including the same, for condensing helium. The pileus-gills type helium condenser includes: a body having a hemispheric shape and formed of a highly thermally conductive metal; a plurality of cooling fins collectively having a pileus gills-like shape and arranged along the circumference of the body to be spaced apart from one another; and a through-hole formed in the center of the body to be adjacent to the cooling fins. | 07-22-2010 |
20100119443 | RADIOTHERAPEUTIC SYSTEM AND METHOD PERFORMED BY NON-INVASIVE AND REAL-TIME TUMOR POSITION TRACKING - A radiotherapeutic system including non-invasive and real-time tumor tracking includes: a signal detector for detecting radioactive rays emitted from a tumor to which the radioactive medical supply is adsorbed and generating an electrical signal; a signal processor for converting the electrical signal generated into a three-dimensional (3D) coordinate signal; a controller for generating a control signal in conjunction with the 3D coordinate signal output by the signal processor; and a radioactive-ray irradiation device for emitting radioactive rays to the tumor, wherein the amount of the radioactive rays is controlled by the controller. | 05-13-2010 |
20100098671 | COMPOSITION FOR PREVENTION OR TREATMENT OF BONE MARROW DAMAGE - Disclosed herein are a composition for prevention or treatment of bone marrow damage comprising Substance-P as an active ingredient; a use of Substance-P for the preparation of a medicament for prevention or treatment of bone marrow damage; a method for prevention or treatment of bone marrow damage comprising administering a therapeutically effective amount of Substance-P to a mammal; an anticancer supplement comprising Substance-P as an active ingredient; a use of Substance-P for the preparation of an anticancer supplement; and a method for prevention or treatment of cancer comprising administering a therapeutically effective amount of Substance-P as an anticancer supplement to a mammal. | 04-22-2010 |
20090220046 | COLLIMATOR DEVICE FOR RADIOTHERAPY AND RADIOTHERAPY APPARATUS USING THE SAME - Provided is a collimator device for radiotherapy including: a body including a first through unit and disposed on a path of high energy radiation which in use is irradiated toward a patient's treatment part; a frame including a through hole corresponding to the first through unit and slidably installed in the body; a plurality of multi-leaf collimators (MLCs) slidably installed in the through hole and including radiation shields; a servo motor coupled to the body and the frame in a power manner so as to slidingly move the frame with respect to the body; and a motor controller externally receiving position displacement data regarding a motion of the patient's treatment part due to a patient's breathing and generating a signal for controlling the driving of the servo motor so that the MLCs follow the patient's treatment part and continuously apply radiation to the patient's treatment part based on the position displacement data. | 09-03-2009 |
20090176888 | COMPOSITION COMPRISING PHYTOSPHINGOSINE OR DERIVATIVE THEREOF - Provided is a composition for cancer treatment including phytosphingosine or a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. | 07-09-2009 |
20090175835 | COMPOSITION FOR TREATING DAMAGE OF CENTRAL OR PERIPHERAL NERVE SYSTEM - The present invention provides a composition for treating damage of central or peripheral nerve system comprising neural precursor cell derived from subcutaneous tissue; neuron obtained by differentiating the neural precursor cell; or oligodendrocyte or Schwann cell obtained by differentiating the neural precursor cell; a use of neural precursor cell derived from subcutaneous tissue, neuron obtained by differentiating the neural precursor cell, or oligodendrocyte or Schwann cell obtained by differentiating the neural precursor cell, for the manufacture of an agent for treating damage of central or peripheral nerve system; a method for treating damage of central or peripheral nerve system which comprises administrating to a mammal a therapeutically effective amount of neural precursor cell derived from subcutaneous tissue, neurons obtained by differentiating the neural precursor cell, or oligodendrocyte or Schwann cell obtained by differentiating the neural precursor cell. Further, the present invention provides a method of preparing the neural precursor cell, neurons, oligodendrocyte or Schwann cell of the present invention. | 07-09-2009 |