ISIS INNOVATION LIMITED Patent applications |
Patent application number | Title | Published |
20160108431 | PREVENTION AND TREATMENT OF ATRIAL FIBRILLATION - There is provided a nucleic acid that inhibits miR-31 in an atrial myocyte, for use in the prevention or treatment of atrial fibrillation in a subject. Also provided is a method for diagnosing or predicting the risk of atrial fibrillation in a subject, said method comprising: (i) determining the amount of miR-31 in a sample from the subject; (ii) comparing the amount of miR-31 in the sample with a reference standard; and (iii) identifying a difference in the amount of miR-31 in the sample relative to the reference standard; wherein an increase in the amount of miR-31 in the sample compared to the reference standard correlates with the presence of or an increased risk of atrial fibrillation in the subject; and wherein a decrease, or no difference in the amount of miR-31 in the sample compared to the reference standard correlates with the absence of an increased risk of atrial fibrillation in the subject. | 04-21-2016 |
20160101094 | ASSAYS, METHODS AND MEANS - A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity. | 04-14-2016 |
20160101080 | ASSAYS, METHODS AND MEANS - A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity. | 04-14-2016 |
20160097080 | ASSAYS, METHODS AND MEANS - A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity. | 04-07-2016 |
20160097079 | ASSAYS, METHODS AND MEANS - A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity. | 04-07-2016 |
20160097078 | ASSAYS, METHODS AND MEANS - A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity. | 04-07-2016 |
20160097077 | ASSAYS, METHODS AND MEANS - A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity. | 04-07-2016 |
20160097076 | ASSAYS, METHODS AND MEANS - A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity. | 04-07-2016 |
20160030544 | IMMUNOGENIC COMPOSITION TO NEISSERIA - The present invention provides an immunogenic composition capable of eliciting an immune response when administered to a human or non-human animal, wherein the composition comprises an isolated protein with one or more of the following properties: i) about 70, 75, 80, 85, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99 or more percent sequence identity to the protein of SEQ ID No: 1 or a fragment, derivative or analog thereof; ii) is a modified factor H binding protein, wherein the factor H binding protein has been modified at least at the position equivalent to position 318 as defined in FIG. | 02-04-2016 |
20150379370 | METHOD AND SYSTEM FOR SIGNAL ANALYSIS - An image of a human, animal or machine subject, is analysed to detect regions which include strong periodic intensity variations, such as a photoplethysmogram (PPG) signal in a human or animal, or some periodic vibration in a machine. The image is divided into plural regions of fixed order is fitted to a representative intensity signal for that region. The poles of the fitted autoregressive model are thresholded by magnitude to select only the pole or poles with a magnitude greater than the threshold. The pole magnitude therefore acts as a signal quality index. The dominant pole is representative of the strongest periodic information and the frequency of that spectral component can be derived from the phase angle of the pole. The image may be redisplayed with image attributes, e.g. colour-coding, according to the pole magnitude in each region of interest and/or the dominant pole phase angle in each region of interest. In the case of a PPG image signal this can give maps of heart rate and breathing rate. | 12-31-2015 |
20150361180 | HLA-E BINDING - The invention relates to a method of testing a compound for biological activity, which method comprises providing cells expressing one of the CD94/NKG2 family of receptors, contacting the cells with recombinant HLA-E under binding conditions in the presence of the test compound, and determining whether the presence of the compound affects the binding of HLA-E to the cells. The HLA-E property of binding to CD94/NKG2 receptors on NK cells and a subset of CD8+ T cells is useful for targeting CD94/NKG2+ cells for a variety of purposes such as identification, isolation, killing or inactivation. | 12-17-2015 |
20150353646 | ASSAYS, METHODS AND MEANS - A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity. | 12-10-2015 |
20150298109 | BIFUNCTIONAL ORGANIC CATALYSTS - The present invention provides a bifunctional catalyst of the formula (1): wherein: each R | 10-22-2015 |
20150249170 | OPTOELECTRONIC DEVICE - The invention provides an optoelectronic device comprising a photoactive region, which photoactive region comprises: an n-type region comprising at least one n-type layer; a p-type region comprising at least one p-type layer; and, disposed between the n-type region and the p-type region: a layer of a perovskite semiconductor without open porosity. The perovskite semiconductor is generally light-absorbing. In some embodiments, disposed between the n-type region and the p-type region is: (i) a first layer which comprises a scaffold material, which is typically porous, and a perovskite semiconductor, which is typically disposed in pores of the scaffold material; and (ii) a capping layer disposed on said first layer, which capping layer is said layer of a perovskite semiconductor without open porosity, wherein the perovskite semiconductor in the capping layer is in contact with the perovskite semiconductor in the first layer. The layer of the perovskite semiconductor without open porosity (which may be said capping layer) typically forms a planar heterojunction with the n-type region or the p-type region. The invention also provides processes for producing such optoelectronic devices which typically involve solution deposition or vapour deposition of the perovskite. In one embodiment, the process is a low temperature process; for instance, the entire process may be performed at a temperature or temperatures not exceeding 150° C. | 09-03-2015 |
20150248949 | HYDROGEL NETWORK - The invention provides a hydrogel network comprising a plurality of hydrogel objects, wherein each of said hydrogel objects comprises: a hydrogel body, and an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body, wherein each of said hydrogel objects contacts another of said hydrogel objects to form an interface between the contacting hydrogel objects. A process for producing the hydrogel networks is also provided. The invention also provides an electrochemical circuit and hydrogel component for mechanical devices comprising a hydrogel network. Various uses of the hydrogel network are also described, including their use in synthetic biology and as components in electrochemical circuits and mechanical devices. | 09-03-2015 |
20150227837 | SYSTEM MONITORING - A method of monitoring a system such as a machine, industrial system, or human or animal patient, to classify the system as normal or abnormal, in which a time-series of measurements of the system are regarded as a function to be compared to a model of normality for such functions. The model of normality can be constructed as a Gaussian Process and test functions compared to the model to derive the probability that they are drawn from the model of normality. A probability distribution for the expected extrema of sets of functions drawn from the model can also be derived and the probability of any extremum of a plurality of test functions being an extremum of a set derived from the model of normality can be obtained. The system can be classified as normal or abnormal based on the extreme probability distribution. Test functions with fewer data points can be compared to the model of normality by marginalisation with respect to the missing data points. | 08-13-2015 |
20150225763 | BIOMARKER - A method for determining the malarial status of a subject, comprising the steps of: providing a biological sample obtained from a subject; and determining the level, or presence, of PF10_0121 (hypoxanthine phosphoribosyltransferase, pHPRT) and/or PF11_0208 (phosphoglycerate mutase, pPGM) in the biological sample. | 08-13-2015 |
20150224346 | PASSIVE ULTRASOUND IMAGING WITH SPARSE TRANSDUCER ARRAYS - A passive compression wave imaging system comprises an array of sensor elements arranged in a sparse array and a processor arranged to: store a plurality of samples of the output from each of the sensor elements over a sample period; derive from the stored samples a value for each of a set of image pixels; wherein for each of the image pixels the processing means is arranged to: define a plurality of different sets of weights for the elements of the sparse array; calculate a component of a pixel value from each of the sets of weights and the stored samples; and sum the components of the pixel value to produce a final pixel value. | 08-13-2015 |
20150204869 | Lipocalin-2 as a Biomarker for Pneumococcal Infection Status and Uses Thereof - A method for determining the pneumococcal infection status of a subject, comprising the steps of: i, providing a biological sample obtained from a subject: ii. determining the level of lipocalin-2 in the biological sample; and iii. comparing the level determined in (ii) with one or more pre-determined reference values. | 07-23-2015 |
20150190256 | STENT AND METHOD OF INSERTING A STENT INTO A DELIVERY CATHETER - Stents and method of inserting a stent into a delivery catheter are disclosed. In a disclosed embodiment, a stent for redirecting blood flow away from an aneurysmal sac is provided. The stent comprises an elongate frame ( | 07-09-2015 |
20150148700 | PERCEPTION LOSS DETECTION - The present invention relates to a device for detecting a state of true perception loss of a human, the device including processing means operable to detect from information on electrical signals sensed adjacent to the scalp of the human the activity of oscillations present in the electrical signals as a marker for the state of true perception loss of the human. | 05-28-2015 |
20150136232 | OPTOELECTRONIC DEVICES WITH ORGANOMETAL PEROVSKITES WITH MIXED ANIONS - The invention provides an optoelectronic device comprising a mixed-anion perovskite, wherein the mixed-anion perovskite comprises two or more different anions selected from halide anions and chalcogenide anions. The invention further provides a mixed halide perovskite of the formula (I) [A][B][X] | 05-21-2015 |
20150129034 | OPTOELECTRONIC DEVICE COMPRISING PEROVSKITES - The invention provides an optoelectronic device comprising a porous material, which porous material comprises a semiconductor comprising a perovskite. The porous material may comprise a porous perovskite. Thus, the porous material may be a perovskite material which is itself porous. Additionally or alternatively, the porous material may comprise a porous dielectric scaffold material, such as alumina, and a coating disposed on a surface thereof, which coating comprises the semiconductor comprising the perovskite. Thus, in some embodiments the porosity arises from the dielectric scaffold rather than from the perovskite itself. The porous material is usually infiltrated by a charge transporting material such as a hole conductor, a liquid electrolyte, or an electron conductor. The invention further provides the use of the porous material as a semiconductor in an optoelectronic device. Further provided is the use of the porous material as a photosensitizing, semiconducting material in an optoelectronic device. The invention additionally provides the use of a layer comprising the porous material as a photoactive layer in an optoelectronic device. Further provided is a photoactive layer for an optoelectronic device, which photoactive layer comprises the porous material. | 05-14-2015 |
20150103343 | TUNABLE OPTICAL FILTER - An apparatus for performing spectroscopy incorporates, between an EM source and a detector, an optical filter comprising a pair of mirrors opposed along the optical axis and shaped to provide an optical cavity with stable resonance and having a cavity length of at most 50 μm and a mode at a wavelength within said band of wavelengths for bandpass filtering EM radiation passing therethrough. The actuator system is arranged to move the mirrors relative to each other along the length of the optical cavity for tuning the wavelength of said mode. | 04-16-2015 |
20150098478 | MINIATURE TUNABLE DYE LASER - A miniature tunable dye laser comprises a pair of mirrors opposed along an optical axis and shaped to provide an optical cavity with stable resonance in at least one mode and having a cavity length of at most 50 μm. A laser dye is inside the optical cavity. A laser pump illuminates the dye with pump EM radiation having a band of wavelengths that is wider than the mode of said cavity An actuator system moves move the mirrors relative to each other along the length of the optical cavity for tuning the wavelength of the mode of said cavity. | 04-09-2015 |
20150077747 | ACTIVE CHEMICAL SENSING USING OPTICAL MICROCAVITY - A sensor comprises a pair of mirrors ( | 03-19-2015 |
20150064098 | PROCESS FOR PRODUCING TWO-DIMENSIONAL NANOMATERIALS - The present invention provides a process for producing a two-dimensional nanomaterial by chemical vapour deposition (CVD), the process comprising contacting a substrate in a reaction chamber with a first flow which contains hydrogen and a second flow which contains a precursor for said material, wherein the contacting takes place under conditions such that the precursor reacts in the chamber to form said material on a surface of the substrate, wherein the ratio of the flow rate of the first flow to the flow rate of the second flow is at least 5:1. Two-dimensional nanomaterials obtainable by said process are also provided, as well as devices comprising said nanomaterials. | 03-05-2015 |
20150031749 | BIOMARKER, USES THEREOF AND THERAPY - A method of determining the Crohn's disease status of a subject comprising the steps of determining the level of miR-29 in a sample from said subject; and comparing the level of miR-29 determined in step (a) with one or more reference values. | 01-29-2015 |
20140376777 | Method Of Locating A Sensor And Related Apparatus - A method of localising a vehicle hosting a sensor comprises capturing data from the sensor providing a sensed scene around the vehicle at a current time, processing the sensed scene to extract a set of features from the sensed scene and determine a position of the vehicle from the sensed scene in relation to a previous position of the sensor, comparing the extracted set of features to one or more stored experiences, wherein each stored experience comprises a plurality of sets of features, where each set of features has been determined from a previously sensed scene, to ascertain whether the sensed scene can be recognised within any of the stored experiences, and if the extracted set of features of the sensed scene are recognised then that stored experience is used to produce an estimate of the position of the vehicle at the current time with respect to the stored experience. | 12-25-2014 |
20140347077 | UTILITY METERING - An apparatus has an input section arranged to receive values representative of the total instantaneous supply of electrical current as a function of time from an alternating voltage supply. Current waveforms comprising sets of values representative of the cyclic waveform of the electric current supply are obtained. A delta waveform generator calculates the difference between a current waveform and an earlier current waveform. An edge detector is arranged to detect an edge or edges in the delta waveform. An analysis section is arranged to identify at least one appliance load based at least on information on the edge or edges detected by the edge detector, and to determine the electrical energy consumed by said appliance load. | 11-27-2014 |
20140347043 | MONITORING ENGINE COMPONENTS - A method for monitoring local defects in a rotating engine component such as a gear uses one or more eddy current sensor(s) arranged to interact with the engine component as it is rotating during service. The eddy current sensor(s) may be carried by one or more teeth of a monitoring gear. A device is arranged to measure an output signal from the eddy current sensor(s) resulting from interaction with the rotating engine component. The output signal is processed so as to detect a change in shape of the output signal indicative of a local defect. | 11-27-2014 |
20140315324 | DEVICE, METHOD AND APPARATUS FOR THE TRANSFER OF ANALYTES - According to the present invention, there is provided a device for transferring an analyte from a reaction chamber to a detector, which detector is capable of detecting said analyte. The device comprises a tubular member having a first end adapted to receive a sample containing said analyte within said reaction chamber and a second end adapted to communicate with a sample inlet of said detector; and a jacket for regulating the temperature of sample passing through the tubular member, wherein said jacket is disposed about at least a portion of the tubular member. Methods of using the device, and apparatus comprising the device, are also provided. The device may be used to transfer an analyte from a reaction chamber to a detector during the course of a chemical reaction, such that the reaction can be monitored in situ. | 10-23-2014 |
20140308597 | Steam Reforming Of Methanol - The invention provides a process for producing H | 10-16-2014 |
20140306117 | APPARATUS AND METHOD FOR RADIATION DETECTION - Embodiments of the invention provide a radiation detector, comprising a convertor comprising an inorganic scintillator for absorbing incident neutrons and outputting photons, a light collecting body arranged in relation to a wavelength shifting fibre for receiving photons from the convertor and directing the photons to the wavelength shifting fibre, and one or more photo-detectors arranged to receive photons from the wavelength shifting fibre and output electrical signals in response thereto. | 10-16-2014 |
20140303739 | ORTHOPAEDIC BEARING AND METHOD OF ASSESSING AN ORTHOPAEDIC IMPLANT - There is provided an orthopaedic bearing comprising at least one capacitive sensing element arranged within the bearing material, and operable to measure a change in capacitance resultant from any compression or tension of the bearing during use. There is also provided a method of assessing an orthopaedic implant including an instrumented orthopaedic bearing. | 10-09-2014 |
20140303454 | REMOTE MONITORING OF VITAL SIGNS - A method of remote monitoring of vital signs by detecting the PPG signal in an image of a subject taken by a video camera such as a webcam. The PPG signal is identified by auto-regressive analysis of ambient light reflected from a region of interest on the subject's skin. Frequency components of the ambient light and aliasing artefacts resulting from the frame rate of the video camera are cancelled by auto-regressive analysis of ambient light reflected from a region of interest not on the subject's skin, e.g. in the background. This reveals the spectral content of the ambient light allowing identification of the subject's PPG signal. Heart rate, oxygen saturation and breathing rate are obtained from the PPG signal. The values can be combined into a wellness index based on a statistical analysis of the values. | 10-09-2014 |
20140303385 | ASYMMETRIC SYNTHESIS OF ORGANIC COMPOUNDS - The present invention provides processes for the production of chiral compounds in a stereoisomeric excess. The present processes involve reacting a hydrometallated alkene compound with a compound comprising a conjugated-bond system under conditions such that the compounds undergo an asymmetric 1,4- or 1,6-conjugate addition reaction, generating a chiral compound in a stereoisomeric excess. The reaction is performed in the presence of a metal catalyst, which catalyst preferably comprises a non-racemic chiral ligand. | 10-09-2014 |
20140299872 | HETEROGENEOUS INTERGRATION OF GROUP III-V OR II-VI MATERIALS WITH SILICON OR GERMANIUM - Substrates for an electronic circuit and device manufacturing methods are disclosed. According to an embodiment, the substrate comprises: a silicon or germanium wafer impregnated with impurities that form one or more deep energy levels within the band gap of the material forming the wafer, wherein at least one of said deep energy levels is positioned at least 0.3 eV away from the conduction band if the level is a donor level or at least 0.3 eV away from the valence band if the level is an acceptor level; and a device layer formed on a surface of said wafer, said device layer comprising electronically functional components formed in a layer of Periodic Table Group III-V or II-VI material. The wafer may be formed from Cz silicon or Cz germanium, for example. | 10-09-2014 |
20140296180 | CYCLIC OLIGOSACCHARIDES FOR USE IN THE TREATMENT AND PREVENTION OF BACTERIAL INFECTION - Compounds which inhibit Wza-mcdiated polysaccharide transport are useful in the prevention or treatment of bacterial infection, in particular of | 10-02-2014 |
20140294842 | Assays, Methods and Means - A novel class of hydroxylases is described having the amino acid sequence of SEQ ID No. 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity. | 10-02-2014 |
20140291815 | PROCESSING A WAFER FOR AN ELECTRONIC CIRCUIT - According to a disclosed embodiment, there is provided a method of processing a silicon wafer for use in a substrate for an electronic circuit, comprising: impregnating the silicon wafer with impurities that form one or more deep energy levels within the band gap of silicon, wherein at least one of said deep energy levels is positioned at least 0.3 eV away from the conduction band if the level is a donor level or at least 0.3 eV away from the valence band if the level is an acceptor level; and pre-processing the silicon wafer, prior to or after said impregnation step, so that precipitation of oxide during, after, or during and after, said impregnating step is suppressed. | 10-02-2014 |
20140249056 | BILAYERS - A method for producing a bilayer, the method comprising: (a) providing a hydrated support and a hydrophilic body immersed in a hydrophobic medium; wherein a first monolayer of amphipathic molecules is formed on an interface between the hydrophobic medium and the hydrophilic body and a second monolayer of amphipathic molecules is formed on an interface between the hydrophobic medium and the hydrated support; and (b) bringing the first monolayer into contact with the second monolayer to form a bilayer of amphipathic molecules, wherein at least part of a cell membrane, comprising cell membrane constituents, is provided in or on the hydrated support and/or in the hydrophilic body, and such that constituents of the cell membrane incorporate into the bilayer during or after the bilayer formation. A bilayer produced by the method of the invention, and uses of the bilayer. | 09-04-2014 |
20140248636 | ASSAY FOR HISTIDINYL HYDROXYLASE ACTIVITY - The present invention relates to assays for monitoring activity of Mina53 and NO66 activities, in particular, to assays for identifying modulators of Mina53 and NO66 activities. The invention also relates to assays to monitor the histidinyl hydroxylase activity of Mina53 and NO66 on their substrates, the human ribosomal protein Rpl27a and Rpl8 respectively. The invention also enables the introduction of S-3-hydroxyhistidinyl residues into peptides and proteins. | 09-04-2014 |
20140239169 | DETECTION OF MEMBRANE PROTEIN-THERAPEUTIC AGENT COMPLEXES BY MASS SPECTROMETRY - According to the present invention, there is provided a method of detecting a complex comprising a membrane protein bound to a therapeutic agent by mass spectrometry. The method comprises: (a) providing a solution comprising a detergent micelle in which said complex is contained; (b) providing a mass spectrometer comprising a nanoelectrospray ionisation source, a mass analyser and a detector; (c) vaporising the solution using the nanoelectrospray ionisation source under conditions such that the complex is released from the micelle; (d) ionising the complex; (e) resolving the ionised complex using the mass analyser; and (f) detecting the resolved complex using the detector. Also provided is a solution comprising a detergent micelle in which a complex is contained, wherein the complex comprises a membrane protein bound to a therapeutic agent. | 08-28-2014 |
20140216173 | DETERMINING TORQUE IN A SHAFT - The present invention relates to an apparatus for determining torque in a shaft, the apparatus comprising an elongate member with a weakened region partway along its length, and means for securing the member to the shaft either side of the weakened region, preferably adjacent each end of the elongate member. The invention extends to a method of localising the twist a shaft undergoes, comprising securing an elongate member to a shaft, wherein the elongate member comprises a weakened region partway along its length. | 08-07-2014 |
20140212407 | TREATMENT OF OBESITY - The present disclosure relates to the treatment, e.g. reduction, of body fat mass levels for example in overweight and obese subjects. The present disclosure also relates to weight control in a subject where obesity should be avoided. Disclosed herein are methods of reducing body fat mass e.g. reducing obesity or preventing weight gain and agents used in such methods whereby the agents inhibit a sulphur containing amino acid. Also included in the present disclosure include, without being limited to, methods for determining regimes for the treatment of obesity as well as other subject matter. | 07-31-2014 |
20140194509 | HYDROXYBUTYRATE ESTER AND MEDICAL USE THEREOF - A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) is an effective and palatable precursor to the ketone body (3R)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia. | 07-10-2014 |
20140179543 | IDENTIFICATION OF SMALL-MOLECULE CANDIDATE THERAPEUTICS CAPABLE OF INHIBITING OR INTERFERING WITH A TARGET PROTEIN-PROTEIN INTERACTION - The present invention provides a method of screening method small-molecule candidate therapeutics capable of inhibiting or interfering with intracellular protein-protein interactions, such as cancer associated oncogenic protein interactions and in particular RAS and LMO2 protein-protein interactions. The present invention also provides methods and assays for rationalized drug design based on identifying small molecular weight protein-protein interaction inhibitor molecules that emulate antibody therapeutics products. | 06-26-2014 |
20140160114 | Transformation of a Three-Dimensional Flow Image - A method of transforming a three-dimensional ultrasound Doppler image that represents flow within a subject uses a three-dimensional ultrasound intensity image that has a common field of view and represents structure within the subject. Within the three-dimensional structural image, there is identified a three-dimensional reference surface that represents the location of a surface of the structure represented by the three-dimensional structural image. A mapping is derived that maps the three-dimensional surface into a two-dimensional plane. The mapping is applied to map the three-dimensional surface of the flow image at the location represented by the three dimensional reference surface into a two-dimensional flow image. | 06-12-2014 |
20140159189 | Semiconductor Detector Device - A semiconductor detector device comprises a layer of semiconductor material for generating charge in response to an input event and an array of pixels for collecting charge. Tracks are connected to the pixels to supply signals representing the collected charge to a reader circuit. The pixels are grouped into sets, all the pixels within a set being connected to the same track, the sets of pixels being interwoven so that so that any group of n adjacent pixels capable of collecting charge generated by a single input event is connected to a combination of n tracks that is unique to the group of pixels, where n has a value of one of 2, 3 or 4. This allows detection of position of the area of charge collection on the basis of temporally coincident signals on a combination of at least n tracks. | 06-12-2014 |
20140155098 | SYSTEM FOR PROVIDING INFORMATION AND ASSOCIATED DEVICES - A system for providing locality information to a user is disclosed. The system comprises at least one magnetic field beacon. Each beacon comprises means for generating a magnetic field encoded with information associated with the beacon. A communication device is provided that comprises means for detecting the encoded magnetic field emitted by the beacon and means for extracting the information encoded in the detected magnetic field. | 06-05-2014 |
20140149325 | SYSTEM MONITOR AND METHOD OF SYSTEM MONITORING - A method of system monitoring or, more particularly, novelty detection, based on extreme value theory in particular a points-over-threshold POT method which is applicable to multimodal multivariate data. Multimodal multivariate data points collected by continuously monitoring a system are transformed into probability space by obtaining their probability density function (pdf) values from a statistical model of normality, such as a pdf fitted to a training data set of normal data. Extremal data is defined as that whose pdf value is below a predetermined threshold and a new analytic function, in particular the Generalised Pareto Distribution (GPD) is fitted to that extremal data only. The fitted GPD can be compared to a GPD fitted to the extremal datapoints of the training data set of normal data to determine if the monitored system is in a normal state. Alternatively a threshold can be set by calculating an extreme value distribution of the GPD fitted to the extremal data of the training data set and setting as the threshold the pdf value which separates a desired proportion, e.g., 0.99 of the probability mass from the remainder. If the minimum pdf value of a set of data points collected from the system is below the threshold, the system may be abnormal. | 05-29-2014 |
20140136556 | METHODS AND SYSTEMS FOR MONITORING THE SEVERITY OF INFECTION IN A GROUP OF INDIVIDUALS - A computer-implemented method of monitoring the severity of infection in a group of individuals. A set of data for each individual is obtained, the data comprising at least one piece of diagnostic test data indicating the level of a biomarker associated with the individual's response to infection. The data is then split into a plurality of segments, each segment comprising all data for each individual within a corresponding one of a plurality of time periods. For each segment, a level of the biomarker across the group of individuals during the time period is estimated. The level of the biomarker for each segment to is then determined provide an indication of the change in severity of infection in the group of individuals over time. | 05-15-2014 |
20140127258 | Viral Vector Immunogenic Compositions - There is provided a composition comprising: (a) a modified vaccinia virus ankara (MVA) vector, wherein said MVA vector comprises a nucleic acid sequence encoding an antigen; and (b) an adjuvant comprising a saponin, or an emulsion. There is also provided a composition comprising: (a) an adenovirus vector, wherein said adenovirus vector comprises a nucleic acid sequence encoding an antigen, and wherein the adenovirus is selected from: a group B adenovirus, a group C adenovirus, and a group E adenovirus; and (b) an adjuvant comprising a saponin, or an emulsion; wherein the group B adenovirus is not an adenovirus 35, the group C adenovirus is not Ad5 having an intact E3 gene region, and the group E adenovirus is not an adenovirus C7. Also provided are corresponding uses of the compositions in medicine. | 05-08-2014 |
20140113820 | MODIFICATION OF TREHALOSE-6-PHOSPHATE LEVELS IN PLANTS - Compounds which are trehalose-6-phosphate or trehalose-6-phosphonate precursors of formula (I) or agriculturally acceptable salts thereof are provided: (I) The compounds are useful in increasing starch production in plants. | 04-24-2014 |
20140111290 | MAGNETO-INDUCTIVE WAVEGUIDE - A magneto-inductive waveguide comprising a plurality of resonant elements, the plurality of resonant elements including a first resonant element comprising a conductive loop broken by at least one capacitive gap, and a second resonant element comprising a conductive loop broken by at least one capacitive gap, the second resonant element for magneto-inductively coupling with the first resonant element; wherein the first resonant element and second resonant element are conductively coupled. | 04-24-2014 |
20140107185 | AAV -VECTORS FOR USE IN GENE THERAPY OF CHOROIDEREMIA - The present invention relates to gene therapy for treatment or prevention of choroideremia. | 04-17-2014 |
20140087399 | ASSAY METHOD FOR PEPTIDE SPECIFIC T-CELLS - A method of assaying for peptide-specific T-cells comprises adding peptide to a fluid sample of fresh peripheral blood mononuclear cells, and detecting a cytokine such as interferon-y produced by T-cells that have been pre-sensitised to the peptide. The assay method is quick and cheap and is expected to be useful for the study of various disease states including Hepatitis B, Hepatitis C, tuberculosis, malaria, HIV and influenza. | 03-27-2014 |
20140051106 | METHOD FOR ASSAYING OGFOD1 ACTIVITY - The present invention relates to assays for monitoring activity of OGFOD1 activity, in particular, to assays for identifying modulators of OGFOD1 activity. The invention also relates to assays to monitor the prolyl hydroxylase activity of OGFOD1 on its substrate, the human ribosomal protein RPS23. The invention also enables the introduction of 3-hydroxyprolyl residues into peptides and proteins. | 02-20-2014 |
20140050762 | DENDRITIC CELLS OBTAINED FROM INDUCED PLURIPOTENT STEM CELLS (IPSCS) - The invention relates to dendritic cells produced from human induced pluripotent stems cells (iPSC). The invention also relates to methods for making and methods of using the dendritic cells of the invention. | 02-20-2014 |
20140001056 | METHOD USING FLUORINATED AMPHIPHILES | 01-02-2014 |
20130337474 | DETECTION OF ACUTE MYELOID LEUKAEMIA - The present invention relates to diagnostic screens, antibodies, methods and kits for detection/prognosis of acute myeloid leukaemia. The diagnostic screen detects the presence (+) or absence (−) of the cell surface polypeptide markers i) CD34+; ii) CD45RA+; and iii) CD90− and/or CD123+. Antibodies specific for one or more of said cell surface polypeptide markers may be used in the diagnostic screen of the invention. Diagnostic and prognostic methods for detecting and monitoring minimal residual disease based on said screen also form part of the invention. | 12-19-2013 |
20130318648 | DIAGNOSIS AND THERAPEUTIC EPITOPE, AND TRANSGENIC PLANT - A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope comprising sequence which is: SEQ ID NO: 1 or 2, or an equivalent sequence from a naturally occurring homologue of the gliadin represented by SEQ ID NO: 3, (ii) an epitope comprising sequence comprising: SEQ ID NO: 1, or an equivalent sequence from a naturally occurring homologue of the gliadin represented by SEQ ID NO: 3, which epitope is an isolated oligopeptide derived from a gliadin protein, (iii) an analogue of (i) or (ii) which is capable of being recognised by a T cell receptor that recognises (i) or (ii), which in the case of a peptide analogue is not more than 50 amino acids in length, or (iv) a product comprising two or more agents as defined in (i), (ii) or (iii), and (b) determining in vitro whether T cells in the sample recognise the agent; recognition by the T cells indicating that the individual has, or is susceptible to, coeliac disease. Therapeutic compositions which comprise the epitope and gliadin proteins which do not cause coeliac disease are also provided. | 11-28-2013 |
20130310271 | TUBERCULOSIS DIAGNOSTIC TEST - A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which can bind a T cell receptor which recognises any of the said peptides, and (ii) determining whether the T cells of said T cell population recognise the peptide(s) and/or analogue(s). The method may performed in vivo. Peptides and a kit which enable the method to be carried out are provided. | 11-21-2013 |
20130287760 | TREATMENT FOR DUPUYTREN'S DISEASE - Musculoskeletal fibroproliferative disorders, such as Dupuytren's disease may be treated by administering locally a TNF-α antagonist. TNF-α antagonists find particular utility in inhibiting the progression of early disease state Dupuytren's disease and other musculoskeletal fibroproliferative disorders and, in combination with extracellular matrix degradation agents (such ascollagenase or matrix metalloproteinase I), treating advanced disease state Dupuytren's disease and, in particular inhibiting recurrence. | 10-31-2013 |
20130261731 | Curved Stent Graft Assembly - A stent graft assembly comprises a graft of flexible material supported by a stent frame that is configured to be deformable between an expanded state and a radially collapsed state. The graft of flexible material has the shape of a tube that is curved along a longitudinal axis of the tube when the graft is in an expanded, undeformed state. The stent graft assembly is deformable into a state in which the graft is deformed into the shape of a tube that is straight. The stent graft assembly may be designed for treatment of a thoracic aorta aneurysm. | 10-03-2013 |
20130238623 | Method of Linking Electronic Database Records - A method of linking electronic database records, wherein each record is associated with a single member from a set of unique members, and wherein each member from the set of unique members has associated with it a plurality of identifiers for uniquely identifying the member. The method comprising the following steps. First, a set of combinations of identifiers is obtained by, for each record, determining a plurality of identifiers using the data stored in the record. Next, a set of clusters of linked combinations of identifiers is created, by creating a link between any combinations that have equal identifiers. For each cluster from the set of clusters, a quality value for the cluster is calculated, and any cluster whose quality value is below a pre-determined threshold is split into two or more clusters by removing one or more links between combinations in the original cluster, if in that case the resulting clusters have higher quality values than the original cluster. Finally, any records whose corresponding combinations of identifiers are members of the same cluster are linked. | 09-12-2013 |
20130215502 | FOCUSING APPARATUS AND METHOD - A focusing apparatus for use with an optical system having a high NA objective lens includes an image forming and capturing mechanism for forming an image in an intermediate image zone and for capturing an image by receiving and refocusing light from a selected focal plane within the intermediate image zone, and a focus adjusting mechanism for adjusting the position of the selected focal plane within the intermediate image zone. The image forming and capturing mechanism includes at least one high NA lens. In use, spherical aberration introduced by the high NA objective lens is reduced. | 08-22-2013 |
20130210040 | DIAGNOSTIC METHOD - It has been demonstrated that the level of sST2 increases in pregnant females suffering from pre-eclampsia. Accordingly, the level of sST2 in a pregnant female can be used to assess risk of developing pre-eclampsia. | 08-15-2013 |
20130206207 | Low Cost Focussing System Giving High Concentrations - There is disclosed a focussing system for concentrating radiation onto a target surface, comprising: a first reflective element forming part of the surface of a cone axially aligned along a first alignment axis, the first reflective element being positioned such that when planar radiation is incident on the first reflective element in a direction parallel to the first alignment axis, the planar radiation is focussed towards a first focus lying along the first alignment axis, wherein said part of the surface of a cone is contained within a sector having an included angle of less than 180 degrees; and a second reflective element having a reflective surface that at all points is flat in a direction parallel to a single reference direction, the second reflective element being positioned between the first reflective element and the first focus such that, when planar radiation is incident on the first reflective element in a direction parallel to the first alignment axis, radiation reflected from the first reflective element onto the second reflective element is focussed towards a second focus. A multiple target focussing system comprising a plurality of focussing systems, solar powered systems using focussing systems, kits, telescopes, defocussing light sources, and methods for assembling focussing systems are also disclosed. | 08-15-2013 |
20130199603 | PHOTOSENSITIVE SOLID STATE HETEROJUNCTION DEVICE - The invention provides a solid-state p-n heterojunction comprising an organic p-type material in contact with an n-type material wherein said heterojunction is sensitised by at least one sensitizing agent, characterised in that the device comprises a cathode separated from said n-type material by a porous barrier layer of at least one insulating material. Also provided are opto-electronic devices such as solar cells or photo-sensors comprising such a p-n heterojunction, and methods for the manufacture of such a heterojunction or device. | 08-08-2013 |
20130197327 | ANALYTE SENSOR - An analyte sensor is disclosed that comprises: | 08-01-2013 |
20130187041 | CHARGED PARTICLE SPECTRUM ANALYSIS APPARATUS - A charged particle spectrum analysis apparatus comprising an electric field generator arranged to subject charged particles to a time-varying electric field, a detector to record charged particle time spectrum data of charged particles which have passed through the electric field, the detector comprising a position-sensitive detection portion, and the time-varying electric field arranged to be activated in synchrony with activation of detector, and the time-varying electric field arranged to subject a predetermined region of said detection portion to consecutive charged particle deflection cycles. | 07-25-2013 |
20130183332 | Treatment and Prevention of Malaria - There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising a Reticulocyte-binding protein Homologue 5 (PfRH5) antigen having at least 90% identity with SEQ ID NO: 1, or a fragment thereof; or which comprise a viral vector that expresses PfRH5 antigen having at least 90% identity with SEQ ID NO: 2, or a fragment thereof. | 07-18-2013 |
20130182160 | IMAGE SENSOR AND METHOD OF SENSING - An image sensor has a plurality of pixels arranged in an array, a selection means for selecting individual pixels in the array, and a shutter means for transmitting a shutter signal to the pixels. The pixels are constructed and arranged to sense incident light only when both selected and in receipt of a shutter signal. The pixels in said array can thus be triggered individually to capture light at different times. | 07-18-2013 |
20130175226 | ACOUSTIC SEPARATORS - An acoustic separator comprises: two parallel chamber walls defining a separation chamber therebetween, each chamber wall defining one side of the chamber; inlet means through which fluid can flow into the chamber; and outlet means through which fluid can flow out of the chamber. One of the chamber walls includes a transducer arranged to transmit pressure waves across the chamber towards the other of the chamber walls which in turn is arranged to reflect the pressure waves to set up a standing wave in the chamber. The outlet means defines an opening in one of the sides of the chamber. | 07-11-2013 |
20130163837 | System and Method for Image Sequence Processing - A method for processing a sequence of images. In an embodiment, one or more training datasets are analyzed having a sequence of images showing a first condition and a sequence of images showing a second condition. A multivariate regression model is used to determine a relationship between relative positions of one or more features in the sequence of images showing the first condition and relative positions of the one or more features in the sequence of images showing the second condition. In an embodiment, the determined relationship is used to predict positions of the one or more features in an inquire sequence of images showing the second condition given an inquire sequence of images showing the first condition. The predicted positions can then be refined using various methods. In an embodiment, sequences of images are aligned to a common time scale. | 06-27-2013 |
20130151444 | METHODS AND APPARATUS FOR UTILISING SOLUTIONS TO SAT PROBLEMS - Computer implemented method to indicate whether a CNF sentence representing a physical system is satisfiable. The method includes structuring a search tree based upon received data representing the CNF sentence. The search tree includes a root node and a plurality of other nodes. The method includes causing the computer to use a search to visit nodes using a decision heuristic at each node to determine which of the branches of the search tree to explore from that node, determining which nodes lie on the solution path, modifying the decision heuristic according to the analysis, generating a trained decision heuristic, and using the trained decision heuristic to process CNF sentences to determine whether those CNF sentences are satisfiable. A shortest path through the search tree provides a solution path and the heuristic can be trained with a set of training instances. | 06-13-2013 |
20130148129 | APPARATUS AND METHOD FOR MEASURING DISTANCE - A method of tracking the position of an object, comprising using reference interference data from first output beam, reference interference data from a second output beam, measurement interference data from the first output beam, measurement interference data from the second output beam, and knowledge of the difference between the absolute phase offset of the first output beam and the absolute phase offset of the second output beam for both a reference interferometer ( | 06-13-2013 |
20130146815 | FORMATION OF BILAYERS OF AMPHIPATHIC MOLECULES - A method of forming bilayers of amphipathic molecules uses droplets of aqueous solution in a hydrophobic medium such as oil. A layer of amphipathic molecules such as a lipid is formed around the surfaces of the droplets. This may be achieved by providing the lipid in the oil and leaving the droplets for a time sufficient to form the layer. The droplets are brought into contact with one another so that a bilayer of the amphipathic molecules is formed as an interface between the contacting droplets. The bilayers may be used for a wide range of studies. The technique has numerous advantages including providing a long lifetime for the bilayers, allowing study of small volumes and allowing the construction of chains and networks of droplets with bilayers in between to study complex systems. | 06-13-2013 |
20130142769 | TREATMENT OF COGNITIVE DISORDERS - The invention relates to treatments of cognitive disorders e.g. Mild Cognitive Disorder comprising the use of agents which are capable of lowering homocysteine levels in a subject, preferably a human subject. Aspects of the invention relate to a method of treating such disorders comprising administering one or more B vitamins e.g. folic acid, Vitamin B | 06-06-2013 |
20130142432 | METHOD OF TRACKING TARGETS IN VIDEO DATA - A method of tracking targets in video data. At each of a sequence of time steps, a set of weighted probability distribution components is derived. At each time step the following steps are performed. First, a new set of components from the components of the previous time step are derived in accordance with a predefined motion model for the targets. The video at the current time step is then analysed to obtain a set of measurements, and the new set of components is updated using the measurements in accordance with a predefined measurement model. Finally, the set of components derived at each time step are analysed to derive a set of tracks for the targets. | 06-06-2013 |
20130114774 | LOCALISED ENERGY CONCENTRATION - A method of producing a localised concentration of energy comprises creating at least one shockwave ( | 05-09-2013 |
20130101550 | PRODUCT AND METHOD FOR PERMEABILISATION OF TUMOR VASCULATURE - The present invention provides a tumour vasculature permeabilising molecule for use in permeabilising vasculature of a tumour for treating, detecting or diagnosing said tumour wherein said tumour vasculature permeabilising molecule is formulated for systemic administration to said patient. A composition comprising a tumour vasculature permeabilising molecule and an appropriate anticancer agent or imaging agent, and a method of treatment or a method of detecting the presence or absence of a tumour are also provided. | 04-25-2013 |
20130098779 | Detection of Phenols - According to the present invention, phenols may be detected using an electrochemical sensor comprising a first compound, a working electrode and an electrolyte in contact with the working electrode, wherein the first compound operatively undergoes a redox reaction at the working electrode to form a second compound which operatively reacts in situ with the phenol, wherein said redox reaction has a detectable redox couple and wherein the sensor is adapted to determine the electrochemical response of the working electrode to the consumption of said second compound on reaction with the phenol. The phenol may be, for example, a cannabinoid or a catechin compound. | 04-25-2013 |
20130090231 | Alumina-Based Ceramic Materials and Process for the Production Thereof - The present invention provides a process for producing a ceramic material, which comprises: (a) forming a green compact by compacting a powder comprising alumina and carbon, wherein the powder is substantially free of silicon carbide and wherein the amount of carbon present in the powder does not exceed 0.1% by weight of the powder; and (b) sintering the green compact under non-oxidising conditions to form a ceramic material comprising alumina and carbon, wherein the green compact is sintered at a temperature of less than 1550° C. Ceramic materials obtainable by said process are also provided. | 04-11-2013 |
20130053544 | PEPTIDE TAG SYSTEMS THAT SPONTANEOUSLY FORM AN IRREVERSIBLE LINK TO PROTEIN PARTNERS VIA ISOPEPTIDE BONDS - The present invention concerns the use of a protein capable of spontaneously forming an isopeptide bond for the development of a peptide tag and binding partner pair wherein said peptide tag and binding partner are capable of covalently binding to each other via an isopeptide bond. The invention also provides a method for developing a peptide tag and binding partner pair which are capable of covalently binding to each other based on a protein which is capable of spontaneously forming an isopeptide bond. Additionally provided are peptide tag and binding partner pairs which are obtainable from isopeptide proteins. Further, specifically developed peptide tags and binding partners are encompassed, together with nucleic acid molecules and vectors which encode those peptides or proteins. | 02-28-2013 |
20130038741 | MULTI-SPECTRAL SCANNING SYSTEM - A method of capturing and processing a multi-spectral image of an object comprises placing the object on a flat-bed scanner ( | 02-14-2013 |
20130029378 | NOVEL ENZYME - The invention provides an isolated formate dehydrogenase (FDH) polypeptide specific for NADP | 01-31-2013 |
20120318132 | Ceramic Composite Materials and Their Production - According to the present invention, a ceramic composite material may be formed by a method comprising the steps preparing a solid solution comprising aluminium oxide, a second component comprising a cation in a first valent state, and a dopant, wherein the dopant is present in an amount of not more than 1000 ppm by weight of the solid solution; and carrying out a treatment on the solid solution to form the ceramic composite material, wherein the treatment changes the valent state of said cation to a second valent state, forming a ceramic composite material comprising grains containing aluminium oxide and a precipitate of particles comprising the cation in the second valent state. The materials may be useful in the manufacture of various products, including wear resistant products and armour. | 12-20-2012 |
20120309684 | CONJUGATES FOR DELIVERY OF BIOLOGICALLY ACTIVE COMPOUNDS - A construct suitable for delivery of a biologically active compound into cells, comprising:
| 12-06-2012 |
20120283340 | PROCESS FOR PRODUCING METHANOL - The present invention relates to a novel process for the production of methanol. The process comprises the heterolytic cleavage of hydrogen by a frustrated Lewis pair comprising a Lewis acid and a Lewis base; and the hydrogenation of CO | 11-08-2012 |
20120282290 | Mycobacterial Vaccines - There is provided a fusion protein or a polynucleotide sequence encoding said fusion protein that comprises first and second domains, wherein the first domain of the fusion protein comprises an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO: 1, or a fragment thereof comprising at least 20 consecutive amino acids thereof; and wherein the second domain of the fusion protein comprises a mycobacterial antigen or an antigenic fragment thereof. Also provided are corresponding therapeutic uses thereof for the protection of primates against mycobacterial infections. | 11-08-2012 |
20120282185 | PARTICLES FOR THE TREATMENT OF CANCER IN COMBINATION WITH RADIOTHERAPY - The invention provides a particle comprising a metal oxide which is doped with at least one rare earth element, wherein the metal oxide is selected from titanium dioxide, zinc oxide, cerium oxide and mixtures of two or more thereof. The invention also provides a pharmaceutical composition comprising the particles, and to uses of the particles and composition in the treatment and diagnosis of cancer. | 11-08-2012 |
20120281797 | HIGH VELOCITY DROPLET IMPACTS - A method of impacting liquid droplets onto a surface includes providing a series of liquid droplets, and directing the liquid droplets at a non-planar target surface to cause a shockwave in the droplets upon impact. An apparatus for impacting liquid droplets onto a surface includes a mechanism to produce a series of liquid droplets, and a mechanism to direct the liquid droplets at a non-planar target surface to cause a shockwave in the droplets upon impact. The non-planar target surface is shaped to intensify the shockwave in the droplets. | 11-08-2012 |
20120280112 | HIGH DYNAMIC RANGE PIXEL - A high dynamic range pixel ( | 11-08-2012 |
20120276012 | Method of Treatment and Screening Method - A method for the prevention or treatment of a cardiovascular disease comprising increasing the intracellular creatine concentration in myocardial cells, in particular by up-regulating the creatine transporter. Also described are screening methods for identifying substances to be used in the prevention or treatment of a cardiovascular disease. | 11-01-2012 |
20120271169 | ULTRASOUND SYSTEMS - A sensing system for sensing the condition of an object comprises a transducer arranged to generate pressure waves directed at the object and detection means, such as a pressure wave detector, arranged to detect cavitation or other processes in the object. The system further comprises processing means arranged to receive detection signals from the detection means, to process the detection signals to measure a signal parameter of the detection signals that varies with a parameter of the object, and may generate a sensor output that varies in response to changes in the signal parameter. | 10-25-2012 |
20120271016 | CATALYSTS - The present invention relates to novel metallocene catalysts of formula I, which is defined herein. The present invention also provides processes for making these catalysts and their use in olefin polymerisation reactions. | 10-25-2012 |
20120264141 | TUBERCULOSIS DIAGNOSTIC TEST - A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which can bind a T cell receptor which recognises any of the said peptides, and (ii) determining whether the T cells of said T cell population recognise the peptide(s) and/or analogue(s). The method may performed in vivo. Peptides and a kit which enable the method to be carried out are provided. | 10-18-2012 |
20120263649 | DETECTION OF MYCOBACTERIA - A method for determining the presence of mycobacteria species in an organism or biological sample, the method comprising adding to the organism or biological sample a probe molecule comprising a substrate and a label, which probe molecule can be incorporated into mycobacteria, the presence of mycobacteria being determined by a detector responsive to the presence of the label, optionally after applying a stimulus; suitable probe molecules include compounds comprising a label and a substrate, which label is can be detected by a detector responsive to the presence of the label, optionally after applying a stimulus, characterised by compound being able to engage with the active site of Antigen 85B (Ag85B) such that it can form simultaneous hydrogen bonds with two or more amino acids in the active site selected from Arg 43, Trp 264, Ser126, His 262 and Leu 42, or the corresponding amino acids in Antigen 85A (Ag85A) or Antigen 85C (Ag85C), at least one of which is with Ser126. | 10-18-2012 |
20120259222 | ULTRASOUND SYSTEMS - An ultrasound system comprises a transducer, a controller arranged to generate control signals arranged to control the transducer to generate pressure waves directed at a target volume, and sensing means arranged to sense cavitation in the target volume. The controller is arranged to receive sensing signals from the sensing means and to vary the control signals in response to the sensing signals thereby to control the cavitation. | 10-11-2012 |
20120257101 | IMAGE CAPTURE DEVICE AND METHOD - An image capture device including a sensor having an active area including a plurality of pixels and a shutter array for controlling the exposure of individual pixels. The pixels are grouped in a plurality of pixel subsets and are arranged to capture a plurality of time-separated lo-res images, which can be viewed sequentially as a movie or combined to form a hi-res still image. | 10-11-2012 |
20120220481 | BILAYERS - A method for producing a bilayer, the method comprising: (a) providing a hydrated support and a hydrophilic body immersed in a hydrophobic medium; wherein a first monolayer of amphipathic molecules is formed on an interface between the hydrophobic medium and the hydrophilic body and a second monolayer of amphipathic molecules is formed on an interface between the hydrophobic medium and the hydrated support; and (b) bringing the first monolayer into contact with the second monolayer to form a bilayer of amphipathic molecules, wherein at least part of a cell membrane, comprising cell membrane constituents, is provided in or on the hydrated support and/or in the hydrophilic body, and such that constituents of the cell membrane incorporate into the bilayer during or after the bilayer formation. A bilayer produced by the method of the invention, and uses of the bilayer. | 08-30-2012 |
20120219960 | METHODS USING PORES - The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the interaction and thereby determining the identity of the nucleotide. The invention also relates to a method of sequencing nucleic acid sequences and kits related thereto. | 08-30-2012 |
20120216865 | HETEROJUNCTION DEVICE - A solid-state p-n heterojunction comprising an organic p-type material in contact with an n-type material wherein said n-type material is surface-sensitised by at least two sensitizing agents comprising an energy donor sensitizing agent and an energy acceptor sensitizing agent and optionally at least one intermediate sensitizing agent, wherein the emission spectrum of the donor sensitizing agent overlaps with the absorption spectrum of the acceptor sensitizing agent and/or at least one intermediate sensitizing agent where present, and the emission spectrum of at least one intermediate sensitizing agent where present overlaps with the absorption spectrum of the acceptor sensitizing agent and wherein the acceptor sensitizing agent individually has a maximum Absorbed Photon to electron Conversion Efficiency of no less than 40% in an equivalent heterojunction when used as sole sensitizing agent. The invention also provides optoelectronic devices such as solar cells or photo sensors comprising such a p-n heterojunction, and methods for the manufacture of such a heterojunction or device. | 08-30-2012 |
20120208002 | Composite Materials Containing Aligned Nanotubes and the Production Thereof - According to the present invention, there is provided a method of forming a composite material comprising nanotubes oriented in a matrix comprising a ceramic material, the method comprising the steps of: providing an array of substantially aligned nanotubes; providing a ceramic matrix material in the form of a solution; applying the solution to the nanotubes; allowing the solution to infiltrate into the array of nanotubes; and sintering the ceramic matrix material to form the composite material, wherein the nanotubes are substantially aligned in the ceramic matrix. Composite materials obtainable by said method are also provided. | 08-16-2012 |
20120178913 | OLEFIN METATHESIS REACTIONS OF AMINO ACIDS, PEPTIDES AND PROTEINS CONTAINING ALLYL SULFIDE GROUPS - A method for the modification of an amino acid, protein or peptide is disclosed. The method comprises reacting a carbon-carbon double bond-containing compound with an amino acid, a protein or a peptide containing an allyl sulfide group in the presence of a catalyst which promotes olefin metathesis, to form a modified amino acid, protein or peptide. Preferred carbon-carbon double bond-containing compounds include carbohydrates. | 07-12-2012 |
20120146007 | SOLID STATE HETEROJUNCTION DEVICE - The present invention provides a solid-state p-n heterojunction comprising a p-type material in contact with an n-type material wherein said n-type material comprises SnO | 06-14-2012 |
20120121646 | Vaccine - The invention relates to a vaccine for the treatment of disease caused by | 05-17-2012 |
20120114666 | NEUROLOGICAL AUTOIMMUNE DISORDERS - The invention relates to a method of diagnosing an autoimmune neurological disorder in a mammal comprising the step of detecting, in a bodily fluid sample from the mammal, autoantibodies to an epitope of at least one Kv1-complex protein; and related methods, assay kits, isolated or purified autoantibody or antibody fragments, or uses thereof. | 05-10-2012 |
20120107802 | METHOD FOR SEQUENCING A HETEROPOLYMERIC TARGET NUCLEIC ACID SEQUENCE - The invention relates to a method for sequencing a heteropolymeric target nucleic acid sequence that involves stochastic sensing. The invention also relates to a method for improving a pore for sequencing a target nucleic acid sequence by modifying one or more sites in the pore. | 05-03-2012 |
20120076818 | IMMUNOGENIC COMPOSITION AND USE THEREOF - The invention relates to an immunogenic composition comprising an adenoviral vector and a pox viral vector, or two different adenoviral vectors, wherein one or more of the vectors encodes one or more target antigens; and related methods, uses and kits. | 03-29-2012 |
20120070355 | Methods and Apparatus for the Production of Carbon-Containing Materials - The present invention provides various methods and apparatus for the production of fullerenes and other carbon-containing materials. In some aspects, the invention provides an arc chamber comprising a graphite element support, wherein the support comprises a rotatable frame adapted for moving each graphite element towards and away from an arc discharge position. In other aspects, the invention provides a collection chamber for collecting carbon-containing materials produced in an arc chamber, wherein the collection chamber comprises an inlet and a rotatable element arranged to direct the carbon-containing material to a wall of the collection chamber, wherein the sectional area occupied by the rotatable element increases with distance from the inlet. In other aspects, the invention provides a collection chamber comprising means for isolating the collection chamber from an arc discharge apparatus and an inlet for the introduction of solvent into the collection chamber. | 03-22-2012 |
20120062986 | FOCUSING APPARATUS AND METHOD - A focusing apparatus for use with an optical system having a high NA objective lens includes an image forming and capturing mechanism for forming an image in an intermediate image zone and for capturing an image by receiving and refocusing light from a selected focal plane within the intermediate image zone, and a focus adjusting mechanism for adjusting the position of the selected focal plane within the intermediate image zone. The image forming and capturing mechanism includes at least one high NA lens. In use, spherical aberration introduced by the high NA objective lens is reduced. | 03-15-2012 |
20120041309 | MAPPING AND CHARACTERIZATION OF CAVITATION ACTIVITY - Apparatus for locating bubbles in a subject comprises a plurality of pressure wave detectors arranged to operate as passive detectors to generate output signals in response to the receipt of pressure waves generated at a source comprising at least one bubble, and processing means arranged to receive signals from the detectors and to determine from the signals the position of the source. | 02-16-2012 |
20120034214 | METHODS AND KITS FOR DETERMINING THE PROGNOSIS OF PULMONARY SARCOIDOSIS - The invention provides a method for determining the prognosis of pulmonary sarcoidosis in an individual subject, comprising conducting gene expression analysis on a sample from the subject. The sample is obtained by bronchoscopy under procedural methods not requiring general anaesthesia. | 02-09-2012 |
20120021311 | Hydrogen Storage Material - Novel mixed alkali metal borohydrides are disclosed which can be used as hydrogen storage materials. Processes for producing the mixed alkali metal borohydrides and their use in hydrogen storage devices are also described. | 01-26-2012 |
20110311965 | METHODS OF ENHANCING TRANSLOCATION OF CHARGED ANALYTES THROUGH TRANSMEMBRANE PROTEIN PORES - The invention relates to enhancing translocation of a charged analyte through a transmembrane protein pore. Translocation is enhanced by increasing the net opposing charge of the barrel or channel and/or entrance of the pore. The invention also relates to pores enhanced in accordance with the invention. | 12-22-2011 |
20110302992 | APPARATUS FOR MEASUREMENT OF GAS CONCENTRATIONS IN BREATH - A device for measuring oxygen uptake and carbon dioxide production by a respiring subject based on the use of absorption spectroscopy. An absorption spectrometer using cavity enhanced absorption spectroscopy at 763 nm to measure oxygen concentration and direct absorption or wavelength modulation spectroscopy at 2.0035 μm for carbon dioxide concentration is incorporated into a breathing tube in proximity to the respiring subject. This provides measurements of oxygen and carbon dioxide concentration with a good temporal resolution which can be combined with measurements of flow rate as a function of time to obtain oxygen uptake and carbon dioxide production on a breath-by-breath basis. The device can also measure the concentration of water vapour and of anaesthetic gases in exhaled breath. | 12-15-2011 |
20110300128 | USE OF FOXP2 AS A MARKER FOR ABNORMAL LYMPHOCYTES AND AS A TARGET FOR THERAPY OF DISORDERS ASSOCIATED WITH ABNORMAL LYMPHOCYTES - The present invention is directed to a method for detecting abnormal lymphocytes said method comprising detecting an amount or expression of the FOXP2 gene in lymphocytes in a sample, wherein an increased amount or expression of the FOXP2 gene in said lymphocytes indicates the presence of abnormal lymphocytes. Additionally, the invention concerns a method for detecting or assessing a condition associated with the presence of abnormal lymphocytes. The methods of the invention may also be useful for diagnosing myeloma or MGUS or for determining the prognosis for patients with lymphoma, myeloma or MGUS. The severity of bone disease or bone colonisation of tumours may also be able to be predicted. Further, treatment of conditions associated with the presence of abnormal lymphocytes using an agent which inhibits FOXP2 expression and/or FOXP2 activity is provided. An antibody which binds to the N-terminus of FOXP2 has also been developed. | 12-08-2011 |
20110272688 | ARYL-ARYL DENDRIMERS - Light emitting devices are described which incorporate, as the light emitting element, a dendrimer of which the constituent dendrons include a conjugated dendritic structure comprising aryl and/or heteroaryl groups connected to each other via bonds between sp | 11-10-2011 |
20110269629 | SUPERCONDUCTING MATERIALS - Partially or fully saturated doped graphene materials are found to be superconducting. The saturation is with hydrogen or halogen. Doping is performed by substitution of carbon atoms or by applying an electric field. Diamond nano-rods are also found to be superconducting. These materials can be used in electronic devices having a gate. | 11-03-2011 |
20110254950 | VISUAL TRACKING OF OBJECTS IN IMAGES, AND SEGMENTATION OF IMAGES - A method is discussed of tracking objects in a series of n-D images ( | 10-20-2011 |
20110237956 | INVESTIGATION OF PHYSICAL PROPERTIES OF AN OBJECT - An imaging system for an object such as human or animal tissue uses scattering of an illuminating electromagnetic wave by acoustic vibrations to generate a scattered electromagnetic wave including Doppler components shifted from the frequency of the illuminating electromagnetic wave by frequencies of the acoustic vibration and multiples thereof. An acoustic transducer apparatus applies acoustic vibrations localised in two or three dimensions in a plurality of regions. A transmitter simultaneously illuminates the object with an illuminating electromagnetic wave that has a frequency in the range from 100 MHz to 100 GHz, the vibration direction of the acoustic vibration having a component parallel to the propagation direction of the illuminating electro-magnetic wave. A receiver receives the scattered electromagnetic wave. A signal processing apparatus derives characteristics of the Doppler components, and stores image data representing the derived characteristic. | 09-29-2011 |
20110237666 | HYDROXYBUTYRATE ESTER AND MEDICAL USE THEREOF - A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) is an effective and palatable precursor to the ketone body (3R)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia. | 09-29-2011 |
20110236418 | Materials and Methods for Improved Vaccination - The invention relates to materials and methods for improved vaccination strategies and in particular to the use of lentivirus comprising nucleic acid encoding an antigen, or antigen presenting cells transduced with such lentivirus, to stimulate immune responses against the encoded antigen, in heterologous prime-boost vaccination regimes. | 09-29-2011 |
20110229880 | GENE SILENCING - The invention provides a mirtron or a gene capable of expressing a mirtron for use in modifying the expression of a target gene in a mammalian cell to prevent or treat a disease, the sequence of the mirtron comprising: (i) a 5′ splice site; (ii) a 3′ splice site; (iii) a branch-point recognition sequence; (iv) a 3′ polypyrimidine tract greater than 15 nucleotides in length; and (v) an antisense sequence that is at least partially complementary to a sequence in the target gene. | 09-22-2011 |
20110201044 | TUBERCULOSIS DIAGNOSTIC TEST - A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which can bind a T cell receptor which recognises any of the said peptides, and (ii) determining whether the T cells of said T cell population recognise the peptide(s) and/or analogue(s). The method may performed in vivo. Peptides and a kit which enable the method to be carried out are provided. | 08-18-2011 |
20110199000 | CHARGED PARTICLE ACCELERATOR AND RADIATION SOURCE - A method of accelerating charged particles using a laser pulse fired through a plasma channel contained in a capillary, wherein the plasma waveguide has deviations along its length that cause deviations in the plasma density contained therein, the deviations in plasma density acting to promote charged particle injection into a wake of a passing laser pulse. A radiation source based on a laser-driven plasma accelerator in a plasma waveguide in which the plasma waveguide and/or laser injection process is/are controlled so as to produce an undulating path for the laser pulse through the waveguide, the undulation exerting a periodic transverse force on charged particles being accelerated in the wake of the laser pulse, the resulting charged particle motion causing controlled emission of high frequency radiation pulses. | 08-18-2011 |
20110195451 | Protein Expression - An isolated DNA molecule having a sequence which comprises in a 5′ to 3′ direction (i) one or more promoter elements, (ii) the geneof interest, and (iii) a poly-adenylation 5 signal, and (iv) a terminator element, and expressing the geneof interest incorporated into the DNA molecule in an expression system, and use of said molecule to enhance expression of a gene of interest. | 08-11-2011 |
20110171234 | Vaccine - The invention relates to a vaccine for the treatment of disease caused by | 07-14-2011 |
20110171220 | PD-1 SPECIFIC ANTIBODIES AND USES THEREOF - One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention, to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject. | 07-14-2011 |
20110171215 | PD-1 SPECIFIC ANTIBODIES AND USES THEREOF - One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention, to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject. | 07-14-2011 |
20110163270 | Metal-Containing Dendrimers - This invention relates to a hat emitting device which comprises at least one layer that contains an organometallic dendrimer having a core comprising a metal cation. The invention also relates to organometallic dendrimers and methods for producing the same. | 07-07-2011 |
20110153246 | UTILITY METERING - An apparatus has an input section arranged to receive values representative of the total instantaneous supply of electrical current as a function of time from an alternating voltage supply. Current waveforms comprising sets of values representative of the cyclic waveform of the electric current supply are obtained. A delta waveform generator calculates the difference between a current waveform and an earlier current waveform. An edge detector is arranged to detect an edge or edges in the delta waveform. An analysis section is arranged to identify at least one appliance load based at least on information on the edge or edges detected by the edge detector, and to determine the electrical energy consumed by said appliance load. Another apparatus has an input section arranged to receive values representative of the current supplied to an installation, such as a house. A store contains appliance data characteristic of the use of electricity by each of a plurality of appliances. A processor is arranged to analyse the received values to detect when an appliance is switched on and determine the fractional change in resistance of a heating appliance from the when it is switched on until it reaches its operating temperature. This information is used to identify what the particular appliance is, and to determine the electrical energy consumption by that appliance. A utility meter for metering the use of at least one utility supplied to a plurality of appliances is also disclosed. An input section is arranged to receive values representative of the use of a first utility. A store contains appliance data characteristic of the use of utilities by each of a plurality of appliances. A processor is arranged to analyse the received values and to determine information on the use of a second utility by each appliance, based on the received values and appliance data. | 06-23-2011 |
20110130449 | Assay for Monitoring Activity of Jmjd6 - The invention provides a method for assaying Jmjd6 activity. | 06-02-2011 |
20110130346 | PEPTIDE CONJUGATES FOR DELVERY OF BIOLOGICALLY ACTIVE COMPOUNDS - A construct comprising a cell delivery peptide covalently attached to a biologically active compound suitable for delivery of said biologically active compound into cells, wherein optionally the cells are cardiac muscle, skeletal muscle, smooth muscle or contractile cells. | 06-02-2011 |
20110112186 | DIAGNOSTIC METHODS - This invention relates to a method of determining the susceptibility of an individual to statin-induced myopathy, comprising detecting the presence or absence of one or more polymorphisms in the SLCO1B1 gene in a biological sample from an individual, whereby the presence of one or more polymorphisms indicates that the individual has altered susceptibility to statin-induced myopathy. | 05-12-2011 |
20110109406 | Microwave Cavity Sensor - Apparatus comprising: a radio frequency (RF) Robinson oscillator comprising: a resonator comprising a sensor rhumbatron, the sensor rhumbatron comprising a cavity member, the cavity member having a re-entrant boss member, the re-entrant boss member being arranged to project into a cavity portion of the cavity member; a feedback element arranged to provide positive radio frequency (RF) feedback to the cavity member thereby to increase a quality factor Q of the cavity member, the feedback element having first and second terminals coupled to the cavity member, the apparatus being operable to cause the oscillator to oscillate at a resonant frequency; and an output arranged to provide a signal that varies according to a value of at least one electrical parameter of the oscillator, said at least one electrical parameter being selected from amongst an electromagnetic loss and a resonant frequency. | 05-12-2011 |
20110099673 | STAGE FOR SCANNING PROBE MICROSCOPY AND SAMPLE OBSERVATION METHOD - It is an object of the invention to provide a stage for scanning probe microscopy that can be used in any kind of SPM and can effectively irradiate light to a sample and a solution near the sample without irradiated light blocked by a cantilever. The stage for scanning probe microscopy of the invention is a stage for scanning probe microscopy for fixing a sample substrate that mounts a sample to be observed thereon and has optical transparency and includes an opening that is provided below a portion where the sample substrate is fixed and that has an opening area included within the sample substrate in plan view. Light is radiated from a bottom surface of the sample substrate onto the sample through the opening. | 04-28-2011 |
20110086049 | Receptor Modulators - Method of identifying a modulator of CD28 comprising comparing a structural model of a candidate modulator with a structural model of CD28 to thereby determine whether the modulator will bind to CD28, wherein the structural model is derived from, or comprises, structural coordinates of a crystal of: (i) CD28, (ii) a fragment of CD28, or (iii) a homologue of (i) or (ii). The crystal of CD28 in a soluble form complexed with the Fab fragment of a mitogenic (superagonistic) antibody has been obtained and used for the determination of the 3D-structure of the receptor. The application also relates to modulators of superagonistic signalling for any receptor of the CD28 family, i.e. to superagonistic antibodies and chimeric proteins thereof, and to the screening of the superagonistic modulators. In the methods of screening, the binding of the candidate modulators to a portion of the receptor proximal to the cell membrane is investigated. | 04-14-2011 |
20110059908 | COMPOSITIONS COMPRISING LIPOTEICHOIC ACID FOR USE IN TREATING PLEURAL EFFUSION OR PNEUMOTHORAX - The present invention relates to lipoteichoic acid T for use in treating pleural effusion or pneumothorax. The present invention also relates to the use of lipoteichoic acid T (LTA-T) in the manufacture of a medicament for treating pleural effusion or pneumothorax. The present invention also relates to a kit comprising a pharmaceutical composition comprising lipoteichoic acid T and instructions indicating that the composition is for use as a pleurodesis agent. In addition, the present invention relates to a method of treating pleural effusion or pneumothorax comprising administration of lipoteichoic acid T to a subject. | 03-10-2011 |
20110059501 | Protein Glycosylation - The present invention relates to methods for glycosylating a protein in which the protein is modified to include an alkyne and/or an azide group. The invention further relates to a protein glycosylated by these methods. | 03-10-2011 |
20110056561 | BRANCHED MATERIALS FOR PHOTOVOLTAIC DEVICES - The invention provides a dye-sensitized photovoltaic device which comprises: a first electrode; a second electrode; and, disposed between the first and second electrodes: an electron acceptor material which comprises a semiconductive metal oxide, a redox mediator material, and a photosensitizing dye which comprises a dendrimer of formula (I): [X] | 03-10-2011 |
20110044912 | Diagnostic And Therapeutic Epitope, And Transgenic Plant - A peptide analogue which is not more than 50 amino acids in length, and which is capable of being recognized by a T cell receptor that recognizes an epitope comprising sequence | 02-24-2011 |
20110030367 | LINEAR MULTI-CYLINDER STIRLING CYCLE MACHINE - An improved method and system for removing blockage from hydrocarbon transfer conduits ( | 02-10-2011 |
20110017218 | TREATMENT SYSTEM - Treatment of a pneuomothroax or other condition wherein unwanted fluid is present in a pleural cavity is achieved using a system comprising a chest device ( | 01-27-2011 |
20100330668 | Interaction Between the VHL Tumour Suppressor and Hypoxia Inducible Factor, and Assay Methods Relating Thereto - The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor α subunits, by targeting HIF α for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF α subunit sequences which may modulate this interaction. | 12-30-2010 |
20100328136 | Resonant Reflector Assembly and Method - A resonant radar reflector assembly comprising first and second reflector members ( | 12-30-2010 |
20100321162 | Wireless Backscatter Interrogation of Passive, Resonant Sensor-LC-Tags - A sensor comprising: a sensor resonant radar reflector member; and a sensor element, the sensor reflector member being configured to resonate at a resonant frequency when irradiated by radio frequency radiation of a corresponding frequency, the sensor being further configured whereby exposure of the sensor element to a target measurand causes a change in the resonant frequency of the sensor reflector member. | 12-23-2010 |
20100298294 | KETONE BODIES AND KETONE BODY ESTERS AS BLOOD LIPID LOWERING AGENTS - The subject disclosure provides compositions for reducing serum cholesterol and/or triglyceride levels in subjects. These compositions can comprise racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol or R-1,3 butandiol alone and can be, optionally, administered in conjunction with a low fat diet to a subject. Alternatively, compositions comprising racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol, R-1,3 butandiol or combinations thereof can be formulated as nutritional supplements (also referred to as nutritional compositions) or incorporated into therapeutic compositions containing a) anti-hypertensive agents; b) anti-inflammatory agents; c) glucose lowering agents; or d) anti-lipemic agents) which are administered to a subject, optionally in combination with a low fat diet, in order to cause a reduction or lowering of: serum cholesterol levels; triglyceride levels; serum glucose levels, serum homocysteine levels, inflammatory proteins (e.g., C reactive protein) and/or hypertension in treated subjects. Alternatively, compositions disclosed herein can be administered alone, or in combination with other therapeutic agents to prevent or reverse vascular disease. | 11-25-2010 |
20100297647 | POLYMERASE-BASED SINGLE-MOLECULE SEQUENCING - The invention relates to an assay method for determining the base sequence in a nucleic acid sample which comprises detection of a single base in said sequence using a polymerase modified to include at least one fluorophore and a dark quencher group; detecting and deducing the amount of energy transfer. | 11-25-2010 |
20100297638 | MOLECULAR ADAPTORS - The invention relates to transmembrane protein pore for use in detecting a analyte in a sample. The pore comprises a molecular adaptor that facilitates an interaction between the pore and the analyte. The adaptor is covalently attached to the pore in an orientation that allows the analyte to be detected using the pore. | 11-25-2010 |
20100294924 | ION SPECTRUM ANALYSING APPARATUS AND METHOD - An ion spectrum analysing apparatus ( | 11-25-2010 |
20100292307 | Construct - A promoter for high level and sustained expression is provided which can be used for gene expression of chosen sequences in general. In particular, a nucleic acid construct comprising a hCEF1 promoter operably linked to a sequence for expression is provided, where the hCEF1 promoter comprises: (i) a human CMV enhancer operably linked to a human EF1 a promoter; (ii) a functional fragment of (i); or (ii) a functional variant of (i) or (ii). | 11-18-2010 |
20100288651 | MULTI-WALLED CARBON NANOTUBE SENSOR COMPRISING INTERCALATING SPECIES AND METHOD OF DETECTION - There is provided a method of detecting an analyte in a sample, which comprises the steps of contacting the sample with a working electrode in the presence of an electrolyte and determining the electrochemical response of the working electrode to the sample, wherein the working electrode comprises a multi-walled carbon nanotube (MWCNT) and wherein detection takes place in the presence of a species which is capable of forming an intercalation compound with a carbon host material. Electrochemical sensors and compositions suitable for use in said method are also provided. | 11-18-2010 |
20100285050 | Compositions and Methods - The invention relates to a composition suitable for inducing a T cell mediated immune response against an influenza virus in a vertebrate, said composition comprising nucleic acid encoding one or more epitopes of one or more internal proteins of influenza virus, wherein said composition comprises nucleic acid encoding at least two said epitopes, at least one epitope being from each of two or more internal proteins of influenza virus. The invention also relates to uses of same and to methods involving same. | 11-11-2010 |
20100284809 | WATER TURBINE - A water turbine is disclosed comprising a rotor mounted to be rotatable about an axis. The rotor comprises at least three blades for causing the rotor to rotate about the axis when the blades are located in flowing water. The rotor comprises a plurality of members in the form of a triangulated structure, and at least one of said members comprises one of said blades. | 11-11-2010 |
20100276347 | PORTABLE WATER PURIFICATION DEVICE - A gravity driven portable water purification device ( | 11-04-2010 |
20100240106 | MUTANT ENZYMES - This invention relates to mutant enzymes with enhanced properties and processes for oxidation of organic compound substrates using such enzymes. | 09-23-2010 |
20100216249 | DNA-Based Biosensors - There is described a method of detection of the protein-dependent coincidence of DNA in a sample which comprises detection using luminescence of one or more luminophores introduced into DNA with one, two or more DNA fragments which fragments are bound using one or more DNA-binding proteins. | 08-26-2010 |
20100179413 | DETERMINATION AND DISPLAY OF MATERIAL PROPERTIES - The invention provides for the visualisation of conventional and parametric images of materials as they are progressively distorted during examination. A conventional image is displayed simultaneously alongside one or more parametric images derived from the original image data, with the parametric images displaying mechanical properties such as elasticity and mobility. The mobility values are calculated from the tracking error obtained from a motion or strain estimation algorithm applied to a sequence of image frames. The values of elasticity and mobility are displayed in a colour overlay on the conventional image background and the transparency of the overlay is varied according to the parameter values to de-emphasise less relevant values. | 07-15-2010 |
20100127251 | Aryl-Aryl Dendrimers - Light emitting devices are described which incorporate, as the light emitting element, a dendrimer of which the constituent dendrons include a conjugated dendritic structure comprising aryl and/or heteroaryl groups connected to each other via bonds between sp | 05-27-2010 |
20100115277 | METHOD AND DEVICE FOR MUTUAL AUTHENTICATION - A method of authenticating communication between a first and second party (or node) over an insecure, high bandwidth communications network, in which the first party (C) authenticates the second party (M) using a communications protocol comprising a first communications phase through a first communications channel over the insecure, high bandwidth communications network to establish a secure mode of communications between the first and second party, followed by a second communications phase of receiving information from the second party over a second communications channel, such as an empirical channel, and enabling a user to make a human comparison of the information received from the second party with information generated by the first party thereby enabling the user to authenticate the second party in the event of the information from both parties agrees. | 05-06-2010 |
20100105883 | PENTALENES - The present invention relates to per-substituted pentalene compounds, including permethylpentalene and precursors thereof. In particular, the invention provides substituted pentalene compounds and methods of preparing substituted pentalene compounds; complexes of metals with substituted pentalene compounds and methods for their production; and the use of complexes of metals with substituted pentalene compounds in catalysis. | 04-29-2010 |
20100096983 | ORGANIC PHOSPHORESCENT MATERIAL AND ORGANIC OPTOELECTRONIC DEVICE - The invention provides a cyclometallated complex comprising the structure of formula I | 04-22-2010 |
20100072886 | Metal-Containing Dendrimers - This invention relates to a light emitting device which comprises at least one layer that contains an organometallic dendrimer having a core comprising a metal cation. The invention also relates to organometallic dendrimers and methods for producing the same. | 03-25-2010 |
20100068783 | TAILORED CONTROL OF SURFACE PROPERTIES BY CHEMICAL MODIFICATION - A process for producing a substrate having an adhesive surface, which process comprises: (a) contacting the substrate with a carbene precursor, which carbene precursor is a compound of the following formula (1): whose substituent groups are SP defined herein, provided that when R is aryl or heteroaryl, said aryl or heteroaryl may be substituted by one, two, three, four or five groups, which groups are independently selected from various groups including -L | 03-18-2010 |
20100053735 | FOCUSING APPARATUS AND METHOD - A focusing apparatus for use with an optical system having a high NA objective lens ( | 03-04-2010 |
20100047284 | METHOD FOR REDUCING SPASMS COMPRISING TREATMENT WITH AN AGENT THAT ELEVATES THE LEVEL OF ONE OR MORE CYCLIC NUCLEOTIDES IN THE MUSCLE - This invention relates to methods for preventing or reducing spasms in smooth muscle, using an agent that elevates the level of one or more nucleotide in the muscle, or an agent which comprises a toxin. The invention also relates to the use of such agents in the manufacture of a medicament for preventing or reducing spasms in smooth muscle. | 02-25-2010 |
20100041075 | Tuberculosis Diagnostic Test - A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which can bind a T cell receptor which recognises any of the said peptides, and (ii) determining whether the T cells of said T cell population recognise the peptide(s) and/or analogue(s). The method may performed in vivo. Peptides and a kit which enable the method to be carried out are provided. | 02-18-2010 |
20100008908 | Treatment of Heart Failure - The treatment of heart failure by administering a therapeutically effective amount of an agent that inhibits hypoxia-inducible factor (HIF). Such agents include small molecule chemical agents and biological agents. | 01-14-2010 |
20090326238 | ASYMMETRIC DENDRIMERS - Asymmetric light-emitting dendrimers having the formulae: (a) CORE-[DENDRITE1]n[DENDRITE2]m and (b) CORE-[DENDRITE]n are disclosed. | 12-31-2009 |
20090313475 | Security in Computing Networks - A system for verifying the security of communications between a set of nodes via a high-bandwidth, insecure communications channel. A number of embodiments are described for enabling authenticated communication between the nodes in an environment wherein there is a high bandwidth Dolev-Yao network amongst the nodes and non-spoofable, low-bandwidth empirical channels between each pair of nodes. | 12-17-2009 |
20090311244 | Screening Method - This invention relates to a novel screening method that identifies simple molecular markers that are predictive of whether a particular disease condition is responsive to a specific treatment. Also, a method of diagnosing the susceptibility of an individual suffering from a disease to treatment with an HDAC inhibitor is provided. Also provided is a method of treating a proliferative disease or a condition which involves a change in cell differentiation or growth rate in a patient. | 12-17-2009 |
20090297551 | ADJUVANT - This invention relates to a novel adjuvant comprising a transfection reagent, and to uses of this adjuvant. In particular, the adjuvant may be used in compositions for eliciting an immune response and in vaccines. | 12-03-2009 |
20090294298 | Detection of Phenols - According to the present invention, phenols may be detected using an electrochemical sensor comprising a final compound, a working electrode and an electrolyte in contact with the working electrode, wherein the first compound operatively undergoes a redox reaction at the working electrodes to form a second compound which operatively reacts in situ with the phenol, wherein said redox reaction has a detectable redox couple and wherein the sensor is adapted to determine the electrochemical response of the working electrode to the consumption of said second compound on reaction with the phenol. The phenol may be, for example, cannabinoid or a catechin compound. | 12-03-2009 |
20090286858 | ASSAYS FOR MODULATORS OF ASPARAGINYL HYDROXYLASE - The present invention is directed to methods of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprising contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate. | 11-19-2009 |
20090208475 | MINA53 ASSAYS - The present invention comprises a method for assaying oxygenase activity the method comprising monitoring oxygenase activity of Mina53. | 08-20-2009 |
20090206428 | Direct Electron Detector - An electron detector ( | 08-20-2009 |
20090186352 | DNA Conformation - Method of detection or diagnosis of abnormal gene expression in an individual comprising determining in a sample from the individual the presence or absence of a chromosome structure in which two separate regions of the gene have been brought into close proximity, to thereby detect or diagnose whether the individual has abnormal gene expression. | 07-23-2009 |
20090169089 | Cell Analysis - A system for performing cell population classification in respect of a biological sample. An image is captured in respect of an optical conduit array containing a plurality of cells and signals received therefrom are used to derive a classification scheme defining classes of cells. This scheme is then applied to classify the cells and data representative of the classes and respective locations in the conduit array of the cells. | 07-02-2009 |
20090162334 | PRODUCTION AND USE OF REGULATORY T CELLS - An ex vivo method for generating a population of Treg capable of suppressing rejection of an organ or tissue transplant from a donor animal, comprises culturing CD4 | 06-25-2009 |
20090148867 | UNIVERSAL FLUORESCENT SENSORS - A probe comprises: (1) a target binding site moiety which is attached to a first fluorescent polypeptide; (ii) a mimic moiety which is capable of binding to the target binding site moiety and is attached to a second fluorescent polypeptide; and (iii) a linker which connects the two fluorescent polypeptides and which allows the distance between said fluorescent polypeptides to vary, said fluorescent polypeptides being so as to display fluorescence resonance energy transfer (FRET) between them, wherein the linker comprises one or more of: (1) a sequence capable of being recognised and bound by an immobilized component; (2) a protease cleavage site; (3) a non-analyte binding site; (4) two or more copies of the sequence (SerGly | 06-11-2009 |
20090099084 | Treatment - The invention provides use of a TSG-6 polypeptide, or a polynucleotide encoding an TSG-6 polypeptide, in the manufacture of a medicament for the treatment or prevention of a bone disease or condition associated with bone resorption by osteoclasts. | 04-16-2009 |
20090097116 | Optical Element and Method of Production - A method of producing an optical element that has spatial variation in refractive index is disclosed. The method comprises: providing a curable liquid crystal composition; applying a spatially varying electric field to the liquid crystal composition to induce a desired spatial variation in refractive index; and curing the liquid crystal composition while the electric field is still applied to fix the spatial variation in refractive index when the electric field is removed. | 04-16-2009 |
20090054362 | COMPOUNDS - The present invention provides novel aptamer derivatives which are useful in binding to and neutralising viruses. Pharmaceutical formulations comprising the aptamers and the use of the aptamers in screening for useful compounds are also provided. | 02-26-2009 |
20080305503 | Diagnostic Test - The invention provides a method of diagnosing | 12-11-2008 |
20080274475 | HLA-E BINDING - The invention relates to a method of testing a compound for biological activity, which method comprises providing cells expressing one of the CD94/NKG2 family of receptors, contacting the cells with recombinant HLA-E under binding conditions in the presence of the test compound, and determining whether the presence of the compound affects the binding of HLA-E to the cells. The HLA-E property of binding to CD94/NKG2 receptors on NK cells and a subset of CD8+ T cells is useful for targeting CD94/NKG2+ cells for a variety of purposes such as identification, isolation, killing or inactivation. | 11-06-2008 |
20080245670 | Electrochemical Detection of Arsenic - Electrochemical methods and materials for the detection of arsenic. In one aspect, arsenic is detected using a working electrode comprising particulate platinum. In another aspect, arsenic is detected using an electrode comprising indium tin oxide and particulate gold. Also provided are methods for the production of electrodes which involve the electrodeposition of gold onto indium tin oxide. | 10-09-2008 |
20080227848 | Assays - A method of identifying an agent which modulates 2-oxoglutarate dependent oxygenase activity, the method comprising contacting a 2-oxoglutarate dependent oxygenase and a test agent in the presence of a substrate comprising one or more ankyrin repeat, or fragment thereof, in conditions under which the substrate is hydroxylated in the absence of the test agent; and determining hydroxylation of the substrate. | 09-18-2008 |
20080226678 | Compositions for Immunizing Against Mycobacterium - A method for generating a T cell immune response in a host involving administering a vectored vaccine comprising a non-replicating or replication impaired viral vector expressing the translation product of a mycobacterial antigen 85A gene. Vectored vaccines and uses thereof are also provided. Also provided is a method of inducing a CD8 and a CD4 memory T cell response against an antigen using an adenovirus vector expressing an antigen or an immunogenic fragment thereof. | 09-18-2008 |
20080221848 | Biomolecular Structure Determination Involving Swarm Intelligence - A method and computer program for determining biomolecular structures from experimental data that includes ambiguous experimental observables comprising the steps of: creating a swarm of molecular structure generators; having the ability to allow the communication between said generators via a global set of molecular restraints; determining said molecular structure in a cooperative manner by using self-optimization of a multi-agent system. In one embodiment, NOESY spectra are used to calculate inter-proton distances of the biomolecular structure and said distances are used as molecular restraints. Moreover, the method involves restrained molecular dynamics simulations, e.g. by simulated annealing. | 09-11-2008 |
20080212103 | Ultra-Short Optical Pulse Measurement Using a Thick Nonlinear Crystal - The invention provides a pulse measurement apparatus and corresponding method. The apparatus comprises: a splitter for splitting a pulse to be measured into two sub-pulses propagating along different beam paths; a non-linear medium, capable of up-conversion of radiation propagating therethrough, arranged in said beam paths; at least one element for interfering the up-converted pulses resulting from propagation of the two sub-pulses in the non-linear medium; and detection apparatus for detecting the result of the interference to obtain at least one of spectral and temporal characteristics of the pulse to be measured. In the non-linear medium, each sub-pulse can be resolved into an o-wave component and an e-wave component propagating through the medium at a predetermined angle, and the phase-matching function for up-conversion by interaction of the o-wave component with the e-wave component in the non-linear medium is selected such that up-conversion is substantially independent of frequency for one of the o-wave or e-wave over a predetermined frequency range, and is frequency selective for the other of the o-wave and e-wave. This phase-matching function produces spectrally-sheared up-converted replicas of the pulse to be measured. | 09-04-2008 |