Fundacio Privada Centre De Regulacio Genomica (CRG) Patent applications |
Patent application number | Title | Published |
20140178329 | VARIANTS OF THE TNF SUPERFAMILY AND USES THEREOF - Described are novel variants of APRIL that modulate signaling via receptor-specific agonist activity, and nucleic acids encoding these variant proteins. Further described is the use of these novel proteins in the treatment of APRIL-associated disorders, in particular, pathologies of the immune system and oncological disorders. | 06-26-2014 |
20110200552 | CYTOKINE DESIGN - The present invention relates to novel cytokines, which have a modified selectivity/specificity for their cognate receptors. In particular, the invention relates to a variant TRAIL protein, which has superior selectivity for the death receptor 4 (TRAIL-RI) over the death receptor 5 (TRAIL-R2). In addition, the invention relates to a variant TRAIL protein which exhibits superior selectivity for the death receptor 4 (TRAIL-R1) over the decoy receptors DcR1 (TRAIL-R3) and DcR2 (TRAIL-R4). | 08-18-2011 |