|enGene, Inc. Patent applications|
|Patent application number||Title||Published|
|20140350091||High Concentration Chitosan-Nucleic Acid Polyplex Compositions - The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provides are methods for altering the diameter of chitosan-nucleic acid polyplexes.||11-27-2014|
|20120142760||COMPOSITIONS AND METHODS FOR REGULATED PROTEIN EXPRESSION IN GUT - The invention provides compositions and methods useful for treating disorders treatable by producing a protein in a regulatable manner in a mucosal cell or tissue of an animal. The treatment methods include in vivo and ex vivo methods, including transplanting in vitro transformed cells that secrete the protein into a mammalian subject.||06-07-2012|
|20110171276||Non-Viral Compositions and Methods for Transfecting Gut Cells In Vivo - The present invention provides chitosan-based nanoparticles that can protect nucleic acids and deliver the same into gut mucosal cells. Compositions and methods for the expression of therapeutic nucleic acids in cells of the gut mucosa are provided. Compositions and methods for delivering therapeutic proteins systemically from cells of the gut mucosa are also provided.||07-14-2011|
|20100261780||Highly Acidic Chitosan-Nucleic Acid Polyplex Compositions - The invention provides highly acidic chitosan-nucleic acid polyplex compositions. The compositions may be used to transfect cells in vitro and in vivo, and are particularly useful for transfecting cells of mucosal epithelia.||10-14-2010|
|20090041740||CANCER TREATMENT BY METABOLIC MODULATIONS - The invention provides compositions and methods for inhibiting the growth or proliferation of hyperproliferative cells or inducing regression of hyperproliferative cells. More specifically, the invention provides compositions and methods for stimulating glycogen accumulation in target cells (e.g., hyperproliferative cells) in order to increase glycogen to a level that is toxic to the target cell.||02-12-2009|
Patent applications by enGene, Inc.