DIPHARMA FRANCIS S.R.L. Patent applications |
Patent application number | Title | Published |
20160031796 | ANTIMUSCARINIC COMPOUND HAVING A LOW CONTENT OF IMPURITIES - Substantially stable to degradation Fesoterodine fumarate, a process for its preparation and a process for the synthesis of specific degradation impurities of Fesoterodine fumarate are disclosed. | 02-04-2016 |
20160015706 | CRYSTALLINE FORMS OF AN ANTIDEPRESSANT COMPOUND - The present invention relates to novel crystalline forms of vortioxetine hydrobromide, in particular three crystalline forms, a process for their preparation, a pharmaceutical composition containing said novel crystalline forms, and a process for the purification of vortioxetine or a salt thereof, comprising the formation of one or more of the novel crystalline forms of vortioxetine hydrobromide described herein. | 01-21-2016 |
20150126526 | CO-CRYSTAL OF AN ANTIDEPRESSANT COMPOUND - Co-crystal of a serotonin reuptake inhibitor, in stable form. | 05-07-2015 |
20150111934 | CRYSTALLINE FORMS OF AN ADRENERGIC AGONIST - The present invention relates to the acetate salt of Mirabegron, in particular in two novel crystalline forms, a process for their preparation and the use of said salt and its crystalline forms in the synthesis of Mirabegron with high yields and chemical purity. | 04-23-2015 |
20150099899 | PROCESS FOR THE PURIFICATION OF 2-PHENYL-2-METHYL-PROPANOIC ACID DERIVATIVES - Process for the preparation of 2-phenyl-2-methyl propanoic acid derivatives, useful as intermediates in the preparation of fexofenadine hydrochloride. | 04-09-2015 |
20150025242 | APIXABAN PREPARATION PROCESS - Process for the preparation of apixaban and intermediates useful for the preparation thereof. | 01-22-2015 |
20140309437 | PROCESS FOR THE PREPARATION OF PHARMACEUTICAL INTERMEDIATES - Process for the preparation of intermediates that are useful in the synthesis of active pharmaceutical ingredients (API), in particular active in the central nervous system. | 10-16-2014 |
20140303402 | PROCESS FOR THE PREPARATION OF SULFONAMIDE COMPOUNDS - Process for the preparation of known sulfonamides having antibacterial activity applicable on industrial scale, which allows their production in high yields and purity, comprising in particular the step of nucleophile aromatic substitution and oxidation in suitable conditions. | 10-09-2014 |
20140275610 | PROCESS FOR THE PREPARATION OF FESOTERODINE OR A SALT THEREOF - A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having low content in impurities. | 09-18-2014 |
20140275542 | SYNTHESIS OF A SEROTONIN REUPTAKE INHIBITOR - Process for the preparation of a piperazinyl derivative, and its intermediates, which has known activity as a serotonin reuptake inhibitor and is used in therapy for treating serious symptoms of depression in adults. | 09-18-2014 |
20140243369 | SYNTHESIS OF A GLYCOSYLTRANSFERASE INHIBITOR - Process for the preparation of animinosugar, and the intermediates thereof, having known activity as a glycosyltransferase inhibitor and used, for example, in the treatment of Gaucher's disease. | 08-28-2014 |
20140148574 | SYNTHESIS OF AN INTERMEDIATE OF AN ANTIVIRAL COMPOUND - Process for the preparation of a cyclopropylamide compound which is useful as a structural unit in a process for the preparation of a viral protease inhibitor. | 05-29-2014 |
20140058107 | APIXABAN PREPARATION PROCESS - Process for the preparation of apixaban and intermediates useful for the preparation thereof. | 02-27-2014 |
20130090474 | PROCESS FOR THE PREPARATION OF PTERIDINE DERIVATIVES - The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin. | 04-11-2013 |
20130030179 | PROCESS FOR THE PREPARATION OF VARENICLINE - It is disclosed a process for the preparation of a compound of formula (I) or a salt thereof, comprising: | 01-31-2013 |
20120165525 | PROCESS FOR THE PREPARATION OF LINAGLIPTIN - The present invention relates to processes for the preparation of 8-(3R)-3-aminopiperidinyl)-7-butyn-2-yl-3 -methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione and novel intermediates useful in its synthesis. | 06-28-2012 |
20120142939 | PROCESS FOR THE PREPARATION OF FOSINOPRIL AND INTERMEDIATES THEREOF - The present invention relates to a process for the preparation of intermediates useful in the synthesis of [1[S(R)],2α,4β]-4-cyclohexyl-1-[[[2-methyl-1-oxypropoxy)propoxy](4-phenylbutyl phosphinyl]acetyl]L-proline, and the synthesis thereof, in particular as sodium salt (fosinopril sodium). | 06-07-2012 |
20110269962 | PROCESS FOR PREPARING STATINS - Process for the preparation of β-ketoester synthetic intermediates useful in the preparation of statins, in particular Pitavastatin. | 11-03-2011 |
20110152367 | PROCESS FOR THE PREPARATION OF FESOTERODINE WITH LOW IMPURITIES CONTENT - Disclosed is a process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having a low content of impurities such as tolterodine and tolterodine isobutyrate. | 06-23-2011 |
20110124917 | PROCESS FOR THE PREPARATION OF CINACALCET AND INTERMEDIATES THEREOF - The present invention relates to a process for the preparation of (R)-(1-Naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenyl)-propyl]-amine or a salt thereof, in particular the hydrochloride, and intermediates useful in its synthesis. | 05-26-2011 |
20110034523 | CRYSTALLINE FORMS OF RUFINAMIDE - Disclosed is a crystalline form of rufinamide selected from:
| 02-10-2011 |
20110028728 | PROCESS FOR THE PREPARATION OF CRYSTALLINE DEXLANSOPRAZOLE - Process for the preparation of crystalline anhydrous (R)-2-[[[3-methyl-4-(2,2,2-trifluoroetoxy)-2-piridyl]methyl]sulphinyl]benzimidazole (dexlansoprazole). | 02-03-2011 |
20100331541 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN - A process for the preparation of 2(R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]-7(8H)-pyrazinyl]-1-(2,4,5-trifluorophenyl)-2-butanamine and intermediates useful for the synthesis thereof. | 12-30-2010 |
20100297711 | PROCESS FOR THE SYNTHESIS OF FOSINOPRIL AND INTERMEDIATES THEREOF - Process for the preparation of intermediates useful in the synthesis of [1[S(R)],2α,4β]-4-cyclohexyl-1-[[[(2-methyl-1-oxypropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline, and the synthesis thereof, in particular as sodium salt. | 11-25-2010 |
20100292506 | PROCESS FOR THE SYNTHESIS OF PREGABALIN - A process for the preparation of a compound of formula (I) is disclosed, | 11-18-2010 |
20100267954 | PROCESS FOR THE PURIFICATION OF PALIPERIDONE - Process for the purification of paliperidone by formation of a salt thereof, such as the hydrochloride. | 10-21-2010 |
20100234616 | METHOD FOR THE PREPARATION OF RUFINAMIDE - The invention provides a novel process for the regioselective preparation of a compound of formula (I) | 09-16-2010 |
20090312550 | ZIPRASIDONE FREE FROM COLORED IMPURITIES AND A PROCESS FOR ITS PREPARATION - Ziprasidone base or a pharmaceutically acceptable salt thereof free from colored impurities, in particular those giving the product a “slightly pink to pink” coloration. | 12-17-2009 |
20090203915 | Process for the preparation of solifenacin - A process for the preparation of (1S,3′R)-quiniclidin-3′-yl-1-phenyl-3,4-dihydro-1H-isoquinolin-2-carboxylate, namely solifenacin, comprising the reaction of a compound of formula (IV) with a compound of formula (V), as herein defined, | 08-13-2009 |
20090156855 | CRYSTALLINE FORM OF (S)-1-PHENYLETHYLAMMONIUM (R)-DIPHENYLMETHANESULPHINYL-ACETATE - Novel crystalline hydrate form of (S)-1-phenylethylammonium (R)-diphenyl-methanesulphinyl-acetate and its use in a process for the preparation of (R)-benzhydrylsulphinylacetamide. | 06-18-2009 |
20090156811 | Process for the Preparation of Bosentan - A process for the preparation of 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-[2,2′]bipyrimidinyl-4-yl]-benzenesulfonamide, bosentan, comprising the reaction of a compound of formula (II) or a salt thereof, | 06-18-2009 |
20090143615 | Process for the Preparation of (S)(+)-3-(Aminomethyl)-5-Methylhexanoic Acid - A process for the preparation of a compound of formula (I), | 06-04-2009 |
20090076277 | Process for the preparation of pyridine-methylsulfinyl compounds - A process for the preparation of a compound of formula (I), or a salt thereof, | 03-19-2009 |
20090062534 | LINEZOLID CRYSTALLINE HYDRATE FORM AND LINEZOLID SALTS - Linezolid salts, useful as such and as intermediates in a process for the preparation of novel and known crystalline linezolid forms, in particular known as Form III. | 03-05-2009 |
20080319229 | PROCESS FOR THE PREPARATION OF CINACALCET - The invention provides a novel process for the preparation of a compound of formula (I) | 12-25-2008 |
20080311635 | PROCESS FOR THE PREPARATION OF (S)(+)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID - A process for the preparation of (S)(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) of formula (I) or a salt thereof, | 12-18-2008 |
20080293948 | PROCESS FOR THE PREPARATION OF KETO COMPOUNDS - A process for the preparation of 4-[1-oxo-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethylbenzeneacetic acid, useful as an intermediate for the preparation of fexofenadine, is provided. | 11-27-2008 |