Calpis Co., Ltd. Patent applications |
Patent application number | Title | Published |
20160120919 | PREVENTIVE OR THERAPEUTIC AGENT FOR RUMINANT ANIMAL MASTITIS - The present invention relates to a substance or method for preventing or treating mastitis in ruminant animals, particularly in dairy cows. Specifically provided are: a preventive or therapeutic agent, a feed additive, a feed, and a pharmaceutical composition for ruminant animal mastitis, characterized by comprising, as an active ingredient, a | 05-05-2016 |
20150322496 | METHOD FOR SCREENING LACTIC ACID BACTERIA HAVING IMMUNOREGULATORY FUNCTION - This invention provides a means for screening for lactic acid bacteria having immunoregulatory functions in a simple and rapid manner. This invention provides a method for screening for or producing lactic acid bacteria having immunoregulatory functions comprising determining the number of the test lactic acid bacteria bound to the uromodulin (Umod) protein, lactic acid bacteria obtained by such method, and an immunoregulatory composition comprising such lactic acid bacteria. | 11-12-2015 |
20150307549 | AGENT FOR PREVENTING ARTERIOSCLEROSIS, AGENT FOR SUPPRESSING VASCULAR INTIMAL THICKENING AND AGENT FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION - Provided is an agent having at least one of an improving effect on vascular endothelial functions and an inhibitory effect on vascular intimal thickening, as well as a prophylactic of arteriosclerosis, which have excellent safety, improve functions associated with the vascular endothelium, have effects of preventing various diseases associated with vascular endothelial functions and of inhibiting vascular intimal thickening, and may be expected to provide prophylactic effect on arteriosclerosis. The agents of the present invention contain, as an active component: (a) Xaa-Pro-Pro, (b) a hydrolysate of animal milk casein containing Xaa-Pro-Pro, or a concentrate thereof, or (c) a fermentation product containing Ile-Pro-Pro and/or Val-Pro-Pro obtained by fermenting a starting material containing milk protein with a bacterial strain of the species | 10-29-2015 |
20150296819 | CONCENTRATE-TYPE MILK-BASED ACIDIC BEVERAGE AND METHOD FOR PRODUCING THE SAME - This invention provides an effective means for inhibiting the growth of microorganisms in a concentrate-type milk-based acidic beverage that contains milk after a package is opened. The concentrate-type milk-based acidic beverage of the invention comprises (A) milk, (B) ε-polylysine, and (C) at least one member selected from among benzoic acid, p-hydroxybenzoic acid esters, and a salt of either thereof, wherein the milk solids-non-fat content is 1.5% to 4.5% by weight, and the Brix value is 40 to 60. | 10-22-2015 |
20150283187 | AGENT FOR ALLEVIATING STRESS-INDUCED BOWEL DISORDER CONTAINING SPECIFIC LACTOBACILLUS GASSERI STRAIN OR TREATED PRODUCT THEREOF - The present application provides | 10-08-2015 |
20150158780 | USE OF BACTERIUM OF GENUS BACILLUS IN CIRCULAR AGRICULTURAL CYCLE - The present invention provides: a method for producing a compost, comprising composting plant-derived organic waste at a weight reduction rate of 95% or more by fermentation treatment, specifically by subjecting the organic waste to fermentation treatment comprising a primary fermentation, which comprises an intermittently agitated fermentation, and a secondary fermentation, which comprises an aerated fermentation, using a microorganism of | 06-11-2015 |
20150079059 | METHOD FOR STERILIZING DOMESTIC ANIMAL LITTER BY MICROORGANISM - This invention relates to a sterilization agent for livestock bedding or a composting accelerator for organic waste or livestock bedding, comprising at least one | 03-19-2015 |
20140322172 | LIPID METABOLISM AND/OR SUGAR METABOLISM IMPROVER CONTAINING LACTIC ACID BACTERIUM OR TREATMENT PRODUCT THEREOF - This invention provides the use of a microorganism capable of improving both lipid metabolism and sugar metabolism. Specifically, the invention relates to: a lipid metabolism and/or sugar metabolism improver comprising, as an active ingredient, a bacterial cell selected from bacteria belonging to the genus | 10-30-2014 |
20140308733 | METHOD FOR INDUCING GERMINATION OF SPORE FORMING BACTERIUM - The present application relates to a method for inducing germination of a spore forming bacterium, specifically, a method for inducing germination of a spore forming bacterium, comprising: using one or more compounds having a phenolic backbone to induce germination of a spore forming bacterium selected from the group consisting of the genus | 10-16-2014 |
20130336943 | MEANS AND METHODS FOR ACTIVATING VAGUS NERVE - An object of the present invention is to provide an effective means and method for activating vagal afferent nerve. The present invention provides a vagus nerve activator comprising bacterial cells and/or a treated product of a lactic acid bacteria as active ingredient(s). | 12-19-2013 |
20130316032 | SUBSTANCE FOR PREVENTING AND IMPROVING ARTHRITIS - This application provides a substance containing disrupted cells of an anti-inflammatory lactic acid bacterium and having an effect of preventing or improving arthritis in a subject, a composition containing the substance and the preparation method thereof, and a method for enhancing the effect of preventing and improving arthritis with the use of the substance. | 11-28-2013 |
20130210732 | AGENT FOR REDUCING RISK IN ONSET OF DISEASE ASCRIBABLE TO NON-DIPPER CIRCADIAN RHYTHM OF BLOOD PRESSURE - An agent for reducing risk in onset of diseases ascribable to non-dipping circadian profile of blood pressure is provided. This agent is capable of effectively lowering SBP from night to early morning in individuals with non-dipping circadian profile of blood pressure, in particular, normal individuals with normal SBP and DBP among them, and is thus capable of reducing risk in onset, particularly likely in the morning, of diseases caused by circadian variation of blood pressure. The agent is intended for administration to such subjects, and contains a hydrolysate or a concentrate thereof, containing Val-Pro-Pro and Ile-Pro-Pro and obtained by hydrolysis of animal milk protein. | 08-15-2013 |
20130089633 | AGENT FOR IMPROVING LIPID METABOLISM - This invention provides an effective means or method for improving lipid metabolism, and a means or method for treatment or prevention of diseases or disorders associated with the lipid metabolism disorder. Specifically, this invention relates to an agent for improving the lipid metabolism comprising, as active ingredients, broken cells of a lactic acid bacterium, and to a method for enhancing an effect of a lactic acid bacterium for improving the lipid metabolism comprising a step of breaking the lactic acid bacterium. | 04-11-2013 |
20130017181 | LIPID-METABOLISM-AMELIORATING AGENT - Methods for lowering serum triglycerides use pharmaceutical agents and food products that have no side effects, are easy to ingest continuously, and have a serum triglyceride-lowering effect are provided. The pharmaceutical agents and food products are lipid metabolism-ameliorating agents and serum triglyceride-lowering agents, which include as an active ingredient a culture of a bacterium belonging to the genus | 01-17-2013 |
20120177622 | RENAL-FUNCTION-AMELIORATING AGENT - A method for improving glomerular filtration rate includes administering to a subject in need thereof an agent containing a culture of a bacterium belonging to the genus | 07-12-2012 |
20120135456 | METHOD AND KIT FOR DETECTION OF GUAIACOL-PRODUCING BACTERIUM - Disclosed is a method for detecting guaiacol-producing bacteria in a specimen comprising culturing the specimen or a dilution thereof on a plate of a solid medium for acidophilic bacteria comprising a compound represented by the following formula, wherein R is —H, —OH, —C(O)H, —C(O)CH | 05-31-2012 |
20120115786 | AGENT FOR REDUCING RISK IN ONSET OF DISEASE ASCRIBABLE TO NON-DIPPER CIRCADIAN RHYTHM OF BLOOD PRESSURE - An agent for reducing risk in onset of diseases ascribable to non-dipping circadian profile of blood pressure is provided. This agent is capable of effectively lowering SBP from night to early morning in individuals with non-dipping circadian profile of blood pressure, in particular, normal individuals with normal SBP and DBP among them, and is thus capable of reducing risk in onset, particularly likely in the morning, of diseases caused by circadian variation of blood pressure. The agent is intended for administration to such subjects, and contains a hydrolysate or a concentrate thereof, containing Val-Pro-Pro and Ile-Pro-Pro and obtained by hydrolysis of animal milk protein. Reduction of risk may be expected in onset, particularly likely in the morning, of various diseases caused by risk of circadian variation of blood pressure, such as cerebral infarction, myocardial infarction,myocardialischemia, atherosclerosis, cardiac failure, cerebral stroke, coronary artery diseases, and peripheral vascular diseases. | 05-10-2012 |
20120035096 | AGENT FOR PREVENTING ARTERIOSCLEROSIS, AGENT FOR SUPPRESSING VASCULAR INTIMAL THICKENING AND AGENT FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION - There is provided an agent having at least one of an improving effect on vascular endothelial functions and an inhibitory effect on vascular intimal thickening, as well as a prophylactic of arteriosclerosis, which have excellent safety, improve functions associated with the vascular endothelium, have effects of preventing various diseases associated with vascular endothelial functions and of inhibiting vascular intimal thickening, and may be expected to provide prophylactic effect on arteriosclerosis or the like. The agents of the present invention contain, as an active component: (a) Xaa-Pro-Pro, (b) a hydrolysate of animal milk casein containing Xaa-Pro-Pro, or a concentrate thereof, or (c) a fermentation product containing Ile-Pro-Pro and/or Val-Pro-Pro obtained by fermenting a starting material containing milk protein with a bacterial strain of the species | 02-09-2012 |
20120009163 | MEANS AND METHODS FOR ACTIVATING VAGUS NERVE - An object of the present invention is to provide an effective means and method for activating vagal afferent nerve. The present invention provides a vagus nerve activator comprising bacterial cells and/or a treated product of a lactic acid bacteria as active ingredient(s). | 01-12-2012 |
20110263516 | VASODILATOR - There is provided a vasodilator having an endothelium-dependent vasodilator effect, a prophylactic of arteriosclerosis, and functional food having an endothelium-dependent vasodilator effect, which is suitable for daily and regular intake and excellent in safety. The vasodilator and the functional food according to the present invention are characterized in at least one of the tripeptides Val-Pro-Pro and Ile-Pro-Pro, or a proteolytic product containing Val-Pro-Pro and/or Ile-Pro-Pro, contained as an active component. | 10-27-2011 |
20110251129 | RHEUMATOID ARTHRITIS-PREVENTIVE AGENT FOR ORAL INTAKE - There is provided a rheumatoid arthritis inhibitor for oral intake that has an inhibitory effect on rheumatoid arthritis and is excellent in safety. The rheumatoid arthritis inhibitor for oral intake of the present invention contains, as an active component, a casein hydrolysate containing free amino acids and peptides obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, or a mixture of free amino acids and peptides contained in the hydrolysate. | 10-13-2011 |
20110092431 | SKIN AGING-INHIBITING PEPTIDE - The present invention provides a peptide and a composition which are suitable for oral ingestion, and which have a skin aging-inhibiting activity, a collagen-production promoting activity, an epidermal turnover promoting activity, and a cutaneous cell-proliferating effect. The present invention also provides a medicament and a functional food which have a skin aging-inhibiting activity, a collagen-production promoting activity, and a cutaneous cell-proliferation promoting activity. The present invention provides a composition including at least one peptide of Asn-Ile-Pro-Pro-Leu, Ile-Pro-Pro-Leu, Ile-Pro-Pro, Pro-Val-Val-Val-Pro-Pro, Val-Pro-Pro-Phe, Val-Pro-Pro, Phe-Pro-Pro-Gln, and Leu-Pro-Pro-Thr. | 04-21-2011 |
20110082281 | CASEIN HYDROLYZATE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF - The present invention relates to a casein hydrolysate containing free amino acids and in vivo indigestible peptides having minimally suppressed in vivo enzymatic digestibility, and expected to express functions, such as hypotensive effect, in living organism, and to a method for preparing such a hydrolysate, and use thereof. The casein hydrolysate of the present invention contains free amino acids and peptides, such as in vivo indigestible peptides including Xaa-Pro and Xaa-Pro-Pro, obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, and has ACE inhibitory activity or hypotensive effect. | 04-07-2011 |
20100248369 | RENAL-FUNCTION-AMELIORATING AGENT - A renal function-ameliorating agent and a serum creatinine-lowering agent, each comprising as an active ingredient a culture of a bacterium belonging to the genus | 09-30-2010 |
20100247575 | AGENTS FOR PROMOTING IGA PRODUCTION - The present invention provides | 09-30-2010 |
20100183576 | LIPID-METABOLISM-AMELIORATING AGENT - Pharmaceutical agents and food products which have no side effects, are easy to ingest continuously, and have a serum triglyceride-lowering effect are provided. A lipid metabolism-ameliorating agent and a serum triglyceride-lowering agent, each comprising as an active ingredient a culture of a bacterium belonging to the genus | 07-22-2010 |
20100167979 | RHEUMATOID ARTHRITIS-PREVENTIVE AGENT FOR ORAL INTAKE - There is provided a rheumatoid arthritis inhibitor for oral intake that has an inhibitory effect on rheumatoid arthritis and is excellent in safety. The rheumatoid arthritis inhibitor for oral intake of the present invention contains, as an active component, a casein hydrolysate containing free amino acids and peptides obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, or a mixture of free amino acids and peptides contained in the hydrolysate. | 07-01-2010 |
20100166877 | PROMOTER OF DIFFERENTIATION AND KERATINIZATION OF EPIDERMIC CELL AND FUNCTIONAL BEVERAGE/FOOD FOR PROMOTION OF KERATINIZATION OF EPIDERMIS - The invention provides functional food and beverage that produce, through oral intake, a promotive effect on normal epidermal keratinization, and an epidermal differentiation and keratinization promoter for use in such functional food and beverage. The epidermal differentiation and keratinization promoter of the present invention contains, as an active component, fermented milk whey obtained by fermentation of milk with bacteria including lactic acid bacteria, such as | 07-01-2010 |
20100151080 | PROCESS FOR PRODUCTION OF FERMENTED MILK AND FERMENTED MILK BEVERAGE/FOOD - The invention provides a method for producing a fermented milk that conveniently gives excellent taste and flavor or functionalities, such as antihypertensive effect, to fermented food and beverages. The method enables effective production of particular peptides having useful functions, such as antihypertensive effect, in the resulting fermented milk. The invention also provides fermented milk food and beverages utilizing the fermented milk, which have excellent taste and flavor and even functionality. The present method includes the steps of (A) enzymatically digesting animal milk casein with protease (1) containing particular proteases such as papain, and (B) fermenting animal milk casein or the like with lactic acid bacteria, to thereby produce VPP, IPP, and YP in the resulting fermented milk. The fermented milk food and beverages of the present invention contain the fermented milk obtained by the present method or a concentrate thereof, and VPP, IPP, and YP at or over particular contents. | 06-17-2010 |
20100151039 | SKIN MOISTURIZING AGENT FOR ORAL INTAKE AND FUNCTIONAL FOODS AND DRINKS - The present invention provides functional food and beverage that produce a skin moisturizing effect through oral intake, that is excellently safe, and that may be taken regularly. The invention also provides a skin moisturizer for oral intake to be used in the functional food and beverage, as well as use thereof. The present skin moisturizer for oral intake contains as an active component fermented milk whey obtained by fermentation of milk with | 06-17-2010 |
20090299036 | AGENT FOR PREVENTING ARTERIOSCLEROSIS, AGENT FOR SUPPRESSING VASCULAR INTIMAL THICKENING AND AGENT FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION - There is provided an agent having at least one of an improving effect on vascular endothelial functions and an inhibitory effect on vascular intimal thickening, as well as a prophylactic of arteriosclerosis, which have excellent safety, improve functions associated with the vascular endothelium, have effects of preventing various diseases associated with vascular endothelial functions and of inhibiting vascular intimal thickening, and may be expected to provide prophylactic effect on arteriosclerosis or the like. The agents of the present invention contain, as an active component: (a) Xaa-Pro-Pro, (b) a hydrolysate of animal milk casein containing Xaa-Pro-Pro, or a concentrate thereof, or (c) a fermentation product containing Ile-Pro-Pro and/or Val-Pro-Pro obtained by fermenting a starting material containing milk protein with a bacterial strain of the species | 12-03-2009 |
20090298773 | METHODS OF PRODUCING FUNCTIONAL MISO - According to the present invention a miso with good flavor and a processed food containing the miso are provided, wherein the miso and the food are expected to have an repressing effect on an increase in blood pressure or hypotensive effect by continually taking the miso or food for routinely dietary habit. The present invention also provides a method of producing a miso, wherein peptides with ACE inhibitory activity are effectively produced in the miso without lowering the quality in flavor of miso. In an embodiment of the present invention, animal milk is added at a content of 10% during a mixing step, or a fermentation and ripening step. | 12-03-2009 |
20090220647 | Method for preventing of formation of abnormal odor in beverage composition - A beverage composition is disclosed that comprises a mixture of a protein hydrolysate and vitamin B2, and also contains an amount of ascorbic acid sufficient to prevent the generation of an off-flavor when the mixture is exposed to light. The off-flavor generated upon exposure to light can be reduced in accordance with the beverage composition of the present invention. Alss disclosed is a method for preventing an off-flavor in a beverage composition containing a protein hydrolysate and vitamin B2, and a process for producing a beverage composition containing a protein hydrolysate and vitamin B2. Furthermore, an agent for preventing an off-flavor in a beverage composition containing a protein hydrolysate and vitamin B2, wherein the agent comprises ascorbic acid as an active ingredient is disclosed. | 09-03-2009 |
20090104167 | Prophylactic/Ameliorating Agent for Menopausal Disorder and Functional Beverage/Food - Disclosed is a method for producing an estrogen-like active intermediate (e.g., secoisolariciresinol) by culturing a lignan (e.g., a lignan derived from | 04-23-2009 |
20090047264 | ANTIALLERGIC AGENT, UTILIZATION THEREOF FOR REDUCING ALLERGY AND METHOD OF REDUCING ALLERGY - The present invention provides an antiallergic agent containing, as an active ingredient, lactic acid bacteria selected from the group consisting of lactic acid bacteria of the species | 02-19-2009 |
20090022690 | BACTERIAL TRANSLOCATION INHIBITOR AND METHOD OF INHIBITING BACTERIAL TRANSLOCATION - A bacterial translocation inhibitor containing live | 01-22-2009 |