Patent application title: COMPOSITIONS FOR HAIR AND BODY APPLICATION
Don Van (San Marcos, CA, US)
Dallas Van Kempen (San Marcos, CA, US)
EQYSS GROOMING PRODUCTS
IPC8 Class: AA01N6512FI
Class name: Drug, bio-affecting and body treating compositions plant material or plant extract of undetermined constitution as active ingredient (e.g., herbal remedy, herbal extract, powder, oil, etc.) containing or obtained from aloe (e.g., aloe vera, etc.)
Publication date: 2012-12-06
Patent application number: 20120308672
The inventive compositions comprise a deionized water based of weight
percent ranging from 55% to 95.7%, 0.30 to 0.35 weight percent of one or
more preservatives selected from the group consisting of DMDM hydantoin,
methylparaben, and polyparaben, 0.05 to 0.10 weight percent of a
chelating agent, 0.001 to 5.05 weight percent of one or more conditioners
and/or moisturizers selected from the groups consisting of
polyquaternium-10, polyethylene glycol derivative of lanolin, cetrimonium
chloride, cetrimonium bromide, Crotein HKP®, mixed
mucopolysaccharides, pyrrolidone carboxylic acid, propylene glycol,
hydrolyzed keratin protein, aloe vera powder, 0.05 to 0.15 weight percent
of an antioxidant selected from the group consisting of citric acid and
vitamin E acetate. The composition, which is in liquid form, may be
applied in the form of a spray or mist, by dipping the affected area in
the liquid, or by pouring a small amount of the liquid.
1. A method of repelling insects on a subject by applying to the subject
an effective amount of a composition comprising: (a) a preservative; (b)
a chelating agent; (c) a botanical; (d) a conditioner or moisturizer; and
(e) an antioxidant.
2. The method of claim 1, where the composition is applied by a spray, wipe, or lotion.
3. The method of claim 1, whereupon a physical barrier of the botanical is formed.
4. The method of claim 1, wherein the botanical is marigold extract.
5. The method of claim 1, wherein the subject is a mammal.
6. The method of claim 5, wherein the mammalian subject is a horse, dog, cat, or human.
7. The method of claim 1, wherein the composition further comprises at least one additional botanical extract selected from the group consisting of, Indian cress, rosemary extract, lavender extract, thyme, clove or a combination thereof.
8. The method of claim 1, wherein the conditioner or moisturizer is selected from the group consisting of polyquaternium-10, polyethylene glycol, cetrimonium chloride, certimonium bromide, mixed mucopolysaccharides, pyrrolidoone carboxylic acid, propylene glycol, hydrolyzed keratin protein, aloe vera, or combinations thereof.
9. The method of claim 1, wherein the antioxidant is selected from the group consisting of citric acid and vitamin E derivatives or a combination thereof.
10. The method of claim 1, wherein the preservative is selected from the group consisting of DMDM (dimethylimidazolidine-2,4-dione) hydantoin and an alkylparaben or a combination thereof.
11. The method of claim 10, wherein the alkylparaben is a methylparaben or a propylparaben.
12. The method of claim 1, wherein the chelating agent is selected from the group consisting of porphine, ethylenediamine and ethylenediaminetetraacetic acid (EDTA).
13. The method of claim 1, wherein the composition further comprises a fragrance.
14. A method of making a composition for controlling unwanted contact with insects comprising: (a) a first mixture of a preservative, a chelating agent, a botanical, a conditioner or moisturizer, and an antioxidant; (b) a second mixture of polysorbate and a fragrance; (c) combining the first and second mixtures; and (d) applying the composition to the skin of a subject to control unwanted contact with insects.
15. The method of claim 14, wherein the botanical is marigold extract.
16. The method of claim 14, wherein the composition is applied to the skin of a subject in the form of a spray, wipe or lotion.
17. A composition effective at controlling unwanted contact with insects of the order Diptera comprising marigold extract, and a chelating agent.
18. The composition of claim 17 further comprising a preservative.
19. A method of preventing unwanted contact with insects of the order Diptera from a horse comprising application of a composition comprising (a) marigold extract; (b) a chelating agent; and (c) a preservative, to the skin of a horse.
20. A method of preventing insect contact with a horse comprising applying to the horse a liquid composition comprising at least 0.2 percent marigold extract.
21. The method of claim 20, wherein the composition is applied to the horse as a spray, wipe, or lotion.
22. The method of claim 20, whereupon a physical barrier is formed.
23. A method of controlling flying insects around a horse comprising applying to a horse a liquid composition comprising at least 0.2 percent marigold extract.
24. The method of claim 23, wherein the composition is applied to the horse as a spray, wipe or lotion.
25. A method of repelling insects from a subject by applying to the subject an effective amount of a composition comprising at least 0.2 percent marigold extract.
CROSS-REFERENCE TO RELATED APPLICATIONS
 This Application is a Continuation of U.S. patent application Ser. No. 11/253,968, titled "Compositions for Hair and Body Application" filed Oct. 19, 2005, which claims the benefit of U.S. Provisional Patent Application No. 60/522,603 filed on Oct. 19, 2004, the contents of which are incorporated herein by reference in their entirety.
FIELD OF THE INVENTION
 The present invention relates to a composition and method for treating hair and skin and more particularly to a composition for application to hair and skin for repelling insects, for moisturizing and/or for repairing damage to skin, nails or hair.
BACKGROUND OF THE INVENTION
 There are many grooming products on the market that either attract, or at least do not discourage, biting insects. This is particularly a problem for products intended for use on animals that are kept outdoors, such as horses, dogs, cats, and even birds. With the incidence and severity of insect-borne diseases on the rise, minimizing opportunities for insect contact is an important component of controlling and preventing such diseases. Products that are intended to address this problem may include added chemicals that act as an insect repellant but are toxic and can be harmful to animals and require humans to wear protective garments when applying. Currently, DEET (N,N,-diethyl-m-toluamide) is the active ingredient in most commercial topical insect repellents. Tests have shown that DEET provides effective and long-lasting protection against mosquitoes, however excessive use of DEET poses a risk of skin irritation or other adverse reactions. Further disadvantages of DEET include a limited spectrum of activity and a strong, unpleasant chemical odor. Also, DEET is a powerful plasticizer that can dissolve or mar plastic surfaces.
 Efforts to develop natural insect repellents have been only partly successful. Such products include oils or citronella, turpentine, cedarwood, eucalyptus and wintergreen, however these have been relatively ineffective against many insects, and some may cause skin or eye irritation.
 Accordingly, there is a need for a safe, non-irritating composition that can be applied to skin and hair that provides beneficial properties, such as moisturizing, while providing an insect repellent function.
SUMMARY OF THE INVENTION
 It is an object of the present invention to provide a composition having insect repellent properties that is safe, non-irritating and effective.
 It is another object of the present invention to provide compositions that impart benefits such as moisturizing and repair to hair, skin and other body areas to which they are applied.
 In an exemplary embodiment, the inventive compositions comprise a deionized water base of weight percent ranging from 55% to 95.7%, 0.30 to 0.35 weight percent of one or more preservatives selected from the group consisting of DMDM hydantoin, methylparaben, and polyparaben, 0.05 to 0.10 weight percent of a chelating agent, 0.001 to 5.05 weight percent of one or more conditioners and/or moisturizers selected from the groups consisting of polyquaternium-10, polyethylene glycol derivative of lanolin, cetrimonium chloride, cetrimonium bromide, Crotein HKP®, mixed mucopolysaccharides, pyrrolidone carboxylic acid, propylene glycol, hydrolyzed keratin protein, aloe vera powder, 0.05 to 0.15 weight percent of an antioxidant selected from the group consisting of citric acid and vitamin E acetate. A preferred embodiment of the invention further comprises 0.01 to 0.23 weight percent of at least three botanicals selected from the group consisting of marigold extract, indian cress extract, rosemary extract, lavender extract, thyme, and clove. Further embodiments of the inventive composition include one or more anti-inflammatory agents, one or more antiseptics, stabilizers and emulsifiers. The composition, which is in liquid form, may be applied in the form of a spray or mist, by dipping the affected area in the liquid, or by pouring a small amount of the liquid into the hand for application or directly onto the affected area.
 The inventive composition for use as an insect repellent provides the described benefits while using only natural ingredients that are safe and effective for their intended purpose. The composition, when mixed as described herein provides a natural insect repellent without the noxious smell and toxic vapors often associated with repellants known in the art. The other claimed compositions provide grooming benefits such as shine, detangling, and hair thickening. The inventive compositions contain primarily natural products and no insecticides and yet provide substantial insect repellent. The inventive compositions are useful and intended for use on most animals, including humans and domestic animals such as horses, dogs, cats and birds.
 The embodiments of the invention include an insect repellant, a hair, coat and nail rebuilder, a daily shampoo, a hair and skin moisturizer, a conditioner and/or detangler.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
 It has long been known by gardeners that the strategic placement of marigolds among other plants in a garden can help protect the other plants. A first exemplary embodiment of the present invention, the formula for which is provided in Example 1 below, is sold commercially under the trademarks Marigold Spray® and Mega Marigold® is a composition that includes marigold extract (synonyms: Calendula extract; Calendula officinalis Linn., extract; Calendula officinalis extract) and other natural botanical extracts that create a physical barrier to flies, mosquitoes, and gnats. The inventor has conducted exhaustive testing using natural ingredient fly sprays containing marigold extract and has found these to be the best product for horses with sensitive skin, young horses, and horses that don't wear fly masks. The inventive composition is so gentle that there are no concerns about spraying the horse's face since it will not burn a horse's eyes, and it is not sticky, so it does not attract and adhere dust to the treated area. Marigold Spray® is a non-toxic spray that can be used safely on a horse's head and ears. The present invention may also be used on other domestic animals, including dogs and cats. The present invention is further considered safe for human use and may be used on the body and the face, since there are no harmful or irritating chemicals. The formula of the first embodiment includes conditioners and moisturizers, providing additional benefits beyond its insect repellant quality.
 A second embodiment, the formula for which is provided in Example 2 below, is a natural botanical moisturizing liquid composition that may be used on humans as well as horses, and other domestic animals, such as dogs and cats. The composition, which may be applied as a spray to hair and skin, does not contain polymers, silicone, oil, or alcohol. The moisturizing liquid attracts moisture and binds it to the hair. Tests have shown that it attracts as much as twenty times the amount of moisture in the composition itself and lasts for as long as 24 hours.
 When used on humans, the natural botanical moisturizing spray enhances hair health, protecting it from sun and heat from hair dryers, curling irons, etc. The liquid composition shines, detangles, is anti-static, is soothing and does not burn. It can be used as an aftershave on the face for men or on women's legs. Women may mist it on the face before applying makeup, allow it dry, then apply makeup and mist again. The improved moisture retention capability provided by the formula causes the makeup to last much longer than when applied to untreated skin.
 For pets, the natural botanical formula may be used whenever a pet is bathed or brushed. The spray does not coat or damage the animal's skin or hair. If the hair is not coated with oil, moisture passes down to the base of the hair to the skin, allowing the skin to breathe more easily. The spray is not sticky, greasy or slippery, so it does not attract and adhere dirt and dust. The natural botanical formula is non-toxic and environmentally friendly, hypoallergenic, and it will not burn the eyes. The formula conditions and moisturizes the coat, prevents dry skin conditions, promotes healthy skin and coat, detangles mane and tail, and enhances color.
 A third embodiment of the present invention, the formula for which is provided in Example 3 below, is an oil-free, silicone-free, leave-on conditioning detangler that maintains the moisture balance within the hair shaft. This liquid composition may be applied in a mist form for humans as well as horses and other domestic animals, such as dogs and cats. This formula prevents the hair from becoming dry, brittle, and breaking off, without the use of oil, silicone, wax, or synthetic polymers. It shines and conditions the hair or coat with a formula that combines the extracts of avocado and aloe vera. The composition detangles without the heaviness common in most conditioners and promotes shine and eases manipulation of the hair. This formula may be a wet or dry leave-on spray that is excellent for long hair. Treatment with this mist leaves the hair anti-static and it stops flyaways.
 A fourth embodiment of the present invention, which is described in Example 4 below, is a natural botanical shampoo that may be used on humans as well as horses and other domestic animals, such as dogs and cats. In humans, the shampoo extends the life of color treated hair, makes perms last longer, and removes chlorine from the hair, which can turn the hair green if the person swims frequently in a pool. The shampoo helps eliminate dry, flaky skin, and enhances hair color. The shampoo contains no synthetic polymers, wax, oil, silicone, harsh detergents or alcohol, and easily rinses clean, leaving no residues, and lets the hair accept moisture from the air. The shampoo is non-toxic, environmentally friendly and does not contain diethanolamine (DEA).
 When used on animals, the coat dries up to fifty percent faster. With horses, the shampoo leaves the hair shaft completely clean, not coated with wax, oil, petroleum by-products, silicone, or synthetic polymers, thereby allowing the hair to accept more moisture from the air. This allows horses to cool out up to fifty percent faster.
 A fifth embodiment of the present invention, the formula for which is provided in Example 5 below, is a rebuilder that may be used on humans as well as horses and other domestic animals, such as dogs and cats. In humans, the rebuilder makes the hair thirty percent stronger so that less hair falls out and the hair will be thicker and fuller. The present invention has been used by chemotherapy patients and by people who are experiencing hair loss due to high blood pressure medication. The present invention has been found to make finger nails thirty percent stronger, and may be used as a moisturizer for dry, calloused hands. In pets, the rebuilder strengthens and repairs dry, damaged coats and cracked paw pads, and corrects the structure of weakened, dry damaged coats and paw pads. The rebuilder stimulates and promotes rapid hair and paw pad repair without the use of silicone, synthetic polymers, oils, or petroleum based products. The rebuilder binds protein to the coat, returning elasticity and restoring strength, removing damaging toxins, medications, and chemical residues. It detangles severely matted hair and is safe to use on dry noses. In horses, it strengthens hair so the hair in the mane and tail won't break off easily and it makes the hair healthier and stronger. It also makes hooves grow from 10% to 50% faster and makes them 30% stronger. Sand cracks are reduced, quarter cracks heal faster, and shoes hold better. The composition is especially helpful for treating shelly-footed horses. The rebuilder is environmentally friendly and non-toxic.
 The compositions of the present invention may also contain as adjuvant materials various substances, such as vitamins, lanolin or its derivatives, bactericides, plant extracts, coloring agents, perfumes, thickeners, buffers, surface active agents, and sequestering agents.
 For purposes of the description of the prevent invention, the following definitions are used:
 "Cationic surface active agents" are those surface active detergent compounds which contain an organic hydrophobic group and a cationic solubilizing group. Typical cationic solubilizing groups are amine and quaternary groups. Quaternary ammonium compounds typically contain an alkyl group of 1 to 30 carbons linked to a nitrogen atom and three alkyl groups containing 1 to 3 carbons or other alkyl groups bearing inert substituents such as phenyl groups. Typical quaternary ammonium detergents are benzyl dimethyl stearyl ammonium chloride (stearalkonium chloride), ethyl dimethyl stearyl ammonium chloride, trimethyl stearyl ammonium chloride, dimethyl ethyl lauryl ammonium chloride, and others.
 "Suspending agents or emulsifiers" in the present invention can be any of several long chain acyl derivatives having about 1 to 30 carbon atoms, or mixtures thereof including but not limited to the glycol ester glyceryl stearate.
 "Esterified forms of vitamins" may have 1 to 30 carbons and alcohols may have 1 to 30 carbons.
 The compositions of the present invention are explained more specifically with reference to the following preparation and formulation examples. The compositions are created in volume by combining the ingredients listed in the examples below. It will be readily apparent that different batch sizes can be obtained by scaling the quantities of ingredients according to the weight percentages listed. An exemplary process for combining the ingredients in Examples 1, 2 and 3 follows the steps of:
 1. Measure water into a tank of sufficient volume to hold all of the ingredients.
 2. Add ingredients in order up to and including Citric Acid.
 3. In another container of sufficient volume to hold all of the ingredients, combine the polysorbates with fragrance until clear.
 4. Add the premixed polysorbates and fragrance from step 3 to the batch in step 1 and 2.
 5. Mix well.
 6. Dispense into appropriate containers for consumer sale and use.
 Five hundred gallons (4,175 lbs) of a botanical composition with insect repellent qualities is prepared by mixing the following formulation:
TABLE-US-00001 Chemical Function Quantity % by Weight Deionized Water carrier 465.6 gallons 93.12 DMDM Hydantoin preservative 8.35 lbs 0.20 Tetrasodium EDTA chelating agent 2 lbs 0.05 Methylparaben preservative 4.1 lbs 0.10 Mixed moisturizer 18.9 grams 0.001 Mucopolysaccharides Cetrimonium Chloride conditioner 85.2 lbs 2.04 Propylene Glycol moisturizer 20.87 lbs 0.50 Ajidew''' N-50 moisturizer 104.4 lbs 2.50 Aloe Vera Powder moisturizer 189 grams 0.01 Marigold Extract 003 insect repellent 8.35 gallons 0.20 Indian Cress Extract toner 189 grams 0.01 Rosemary Extract toner 189 grams 0.01 Lavender Extract anti- 189 grams 0.01 inflammatory Citric Acid-50% antioxidant 4.2 gallons 0.05 Polysorbate 20 stabilizer 16.7 gallons 0.40 Polysorbate 80 emulsifier 16.7 gallons 0.40 Raspberry Fragrance fragrance 16.7 gallons 0.40 FXO-303 Defoamer defoamer 94.7 grams 0.005 Total Volume/Weight 500 gal/4,175 lbs
 The botanical insect repellent composition is preferably applied as a spray or mist.
 Five hundred gallons of a natural botanical liquid composition according to the present invention is prepared by mixing the following formulation:
TABLE-US-00002 Chemical Function Quantity % by Weight Deionized Water carrier 467 gallons 94.25 DMDM Hydantoin preservative 8.35 lbs 0.20 Tetrasodium EDTA chelating agent 2.1 lbs. 0.05 Methylparaben preservative 4.1 1bs 0.10 Cetrimonium Chloride conditioner/ 85.2 lbs 2.04 (cetyl trimethyl anti-static ammonium chloride) Mixed moisturizer 19 grams 0.001 Mucopolysaccharides Propylene Glycol moisturizer 21.0 gallons 0.50 Ajidew ® N-50 moisturizer 104.4 lbs 2.50 Aloe Vera Powder moisturizer 189 grams 0.01 Citric Acid-50% antioxidant 4.2 gallons 0.05 Australian Mango fragrance 16.7 1bs 0.40 Fragrance Polysorbate 20 stabilizer 16.7 lbs 0.40 Polysorbate 80 emulsifier 16.7 lbs 0.40 XF0-303 Defoamer defoamer 94.7 grams 0.005 Total Volume/Weight 500 gal/4,175 lbs
 Cetrimonium chloride, common name trimethylhexadecylammonium chloride, provides anti-static properties and is commercially available from a number of different chemical suppliers, including the Genamin® product line sold by Clarient Corporation, Mount Holly, N.C., and the Maquat® CETAC products sold by Mason Chemical Company, Arlington Heights, Ill.
 XFO-303 Defoamer is available from Ivanhoe Industries Inc., Zion, Ill.
 Five hundred gallons (4,175 lbs.) of silicone-free detangling composition according to the present invention is prepared by mixing the following formulation:
TABLE-US-00003 Chemical Function Quantity % by Weight Deionized Water carrier 479 gallons 95.7 DMDM Hydantoin preservative 8.35 lbs 0.20 Tetrasodium EDTA chelating agent 2.1 lbs 0.05 Methylparaben preservative 4.0 lbs 0.10 Cetrimonium bromide conditioner 41.8 lbs 1.00 DL-Panthenol vitamin 20.9 gallons 0.50 Crotein HKP conditioner 16.7 gallons 0.40 Avocado extract moisturizer 189 grams 0.01 Aloe vera powder moisturizer 189 grams 0.01 Citric Acid-50% antioxidant 4.2 gallons 0.05 Polysorbate 20 stabilizer 33.4 gallons 0.80 Polysorbate 80 emulsifier 33.4 gallons 0.80 Pear Fragrance fragrance 16.7 gallons 0.40 XFO-303 Defoamer defoamer 94.7 grams 0.005 Total Volume/Weight 500 gal/4,175 lbs
 Crotein® HKP is a hydrolyzed keratin protein from human hair that penetrates into the hair cortex for conditioning damaged hair. Crotein HKP is available from Croda International Plc, East Yorkshire, U.K.
 The detangling composition is preferably applied as a mist.
 A natural botanical shampoo composition is prepared by mixing the following formulation:
TABLE-US-00004 % by Ingredient Function Quantity Weight Deionized Water carrier 270 gallons 55.258 Mackstat ® DM preservative 8.35 lbs 0.20 (DMDM Hydantoin) Methylparaben preservative 8.35 lbs 0.20 Tetrasodium EDTA chelating agent 2.1 lbs 0.05 Allantoin healing gent 2.1 lbs 0.05 (anti- inflammatory) Celquat ® SC-240C conditioner 16.7 lbs 0.40 (polyquatemium-10) Ajidew ® N-50 moisturizer 12.53 lbs 0.30 (PCA) Aloe Vera Powder moisturizer 189 grams 0.01 Mixed moisturizer 18.9 grams 0.001 Mucopolysaccharides Incromectant ® clarifying agent 6.25 grams 0.15 AMEA-70 (acetamide MEA) Urea USP antiseptic 6.25 grams 0.15 Laneto ®-50 moisturizer 41.75 gallons 1.0 Sodium Laureth Sulfate surfactant 1461.0 lbs 35.0 Chembetaine ® C surfactant 188.0 lbs 4.50 (cocamidopropyl betaine) Lavender Extract anti-inflammatory 189 grams 0.01 Thyme antiseptic 189 grams 0.01 Clove anti-inflammatory 189 grams 0.01 Australian Mango fragrance 16.7 lbs 0.40 Fragrance Citric Acid-50% anti-oxidant 6.26 lbs 0.15 Cocamide DEA thickener/ 75.2 lbs 1.80 stabilizer Salt (NaC1) antiseptic 25 lbs 0.25 Blue #1 dye 18 grams 0.001 Total Volume/Weight 500 gal/4,175 lbs
 In the foregoing listing, Mackstat® is DMDM hydantoin, a preservative used in the manufacture of cosmetic products, available from McIntyre Group,. Ltd., University Park, Ill.
 Celquat®SC-240C, a conditioner, is a polyquaternium cation (polyquaternium-10) resulting from a reaction of hydroxyethyl cellulose and an amine or amide. Celquat®SC240C is commercially available from National Starch & Chemical (Bridgewater, N.J.).
 Ajidew® is the organic acid, pyrrolidone carboxylic acid (PCA). The sodium salt of PCA (Na PCA) is a natural humectant in skin. Na PCA is extremely hygroscopic and imparts a pleasant and moist feeling to skin and hair, and it helps increase softness and elasticity. Pyrrolidone carboxylic acid, which is also referred to as pyroglutamic acid has two stereoisomers (D and L). Both stereoisomers are suitable for use in the present invention. Furthermore, blends of the two stereoisomers may also be used. The L stereoisomer is most preferred. Ajidew° is commercially available from Ajinomoto Co. Inc. (Tokyo, Japan) and Ajinomoto USA, Inc. (Paramus, N.J.).
 The D stereoisomer of pyroglutamic acid is also known by the following names: D-Proline, 5-oxo-(+)-2-Pyrrolidone-5-carboxylic acid, (+)-Pyroglutamic acid, (R)-2-Pyrrolidone-5-carboxylic acid, 5-Oxo-D-proline, D-2-Pyrrolidone-5-carboxylic acid, D-Pyroglutamic acid, D-Pyrrolidinonecarboxylic acid, and D-Pyrrolidonecarboxylic acid.
 The L stereoisomer of pyroglutamic acid is also known by the following names: L-Proline, 5-oxo-(-)-2-Pyrrolidone-5-carboxylic acid, (-)-Pyroglutamic acid, (5S)-2-Oxopyrrolidine-5-carboxylic acid, (S)-(-)-2-Pyrrolidone-5-carboxylic acid, (S)-2Pyrrolidone-5-carboxylic acid, (S)-5-Oxo-2-pyrrolidinecarboxylic acid, (S)-Pyroglutamic acid, 2-L-Pyrrolidone-5-carboxylic acid, 2-Pyrrolidinone-5-carboxylic acid, 5-Carboxy-2-pyrrolidinone, 5-Oxo-L-proline, 5-Oxoproline, 5-Pyrrolidinone-2-carboxylic acid, Glutimic acid, Glutiminic acid, L-2-Pyrrolidone-5-carboxylic acid, L-5-Carboxy-2-pyrrolidinone, L-5-Oxo-2-pyrrolidinecarboxylic acid, L-5-Oxoproline, L-Glutamic acid, gamma-lactam, L-Glutimic acid, L-Glutiminic acid, L-Pyroglutamic acid, LPyrrolidinonecarboxylic acid, L-Pyrrolidonecarboxylic acid, Oxoproline, PCA, Pidolic acid, Pyroglutamic acid, Pyrrolidinonecarboxylic acid, Pyrrolidone-5-carboxylic acid, and Pyrrolidonecarboxylic acid.
 The DL form of pyroglutamic acid (a mixture of the D and L stereoisomers) is known by the following names: DL-Proline, 5-oxo-(±)-2-Pyrrolidone-5-carboxylic acid, (±)-Pyroglutamic acid , 5-Oxo-DL-proline, DL-2-Pyrrolidinone-5-carboxylic acid, DL-2-Pyrrolidone-5-carboxylic acid, DL-Pyroglutamate, DL-Pyroglutamic acid, DL-Pyrrolidonecarboxylic acid, and Oxoproline. The DL form is also commercially available under the trade name Ajidew® A 100.
 Laneto®-50 is a polyethylene glycol derivative of lanolin that provides moisturizing, lubricating and emollient properties, and is commercially available from RITA Corp., Woodstock, Ill.
 Incromectant® AMEA-70, available from Croda International Plc, East Yorkshire, U.K., is a clear liquid clarifying agent, also known as acetamide MEA or acetylethanolamine.
 A composition for rebuilding or repairing tissue, such as hair, skin, nails, or horse's hooves, is prepared by mixing the following formulation which is created in two phases, oil and water, which are then combined to produce 250 gallons of liquid.
TABLE-US-00005 Chemical Function Quantity % by Weight Water Phase Deionized Water Carrier 204 gallons/1700 lbs 81.4 Methylparaben preservative 2.1 lbs 0.10 Versene ® chelating agent 2.1 lbs 0.10 Stearalkonium conditioner/ 177.5 lbs 8.50 Chloride anti-static Cetrimonium conditioner 20.9 lbs 1.00 Chloride Oil Phase Cetearyl Alcohol emulsifier 52.2 lbs 2.50 Glyceryl Stearate emulsifier 73.1 lbs 3.50 PEG 40 Castor Oil emulsifier 31.3 lbs 1.50 Propylparaben preservative 1 lbs 0.05 Vitamin E Acetate antioxidant 3.1 lbs 0.15 Panthenol vitamin 4.2 lbs 0.20 Hydrolyzed Keratin protein 6.2 lbs? 0.30 Protein DMDM Hydantoin preservative 4.2 lbs 0.2 Coconut Fragrance fragrance 10.4 lbs 0.50 Pineapple Fragrance fragrance Total Volume/Weight 250 gal/2,088 lbs
 Versene® is tetrasodium EDTA, a chelating agent that is commercially available from The Dow Chemical Company, Midland, Mich.
 PEG 40 Castor Oil is an emulsifier available from a number of chemical suppliers including Lambert Technologies Corp., Gurnee, Ill.
 The tissue rebuilding/repairing composition is applied directly to the affected area by either dipping the affected area, such as finger nails, into the liquid, or by pouring a small amount of the liquid into the palm of the hand and applying with the hand.
 The compositions described herein are effective for improving the condition of the skin, hair and nails of humans, hair and coats of animals, and the hooves of hoofed animals. The natural ingredients are safe and non-irritating. The marigold-based spray, while provide moisturizing properties also serves as an insect repellent that is DEFT-free and safe to use for humans and animals.
 While the invention has been described in connection with one or more preferred embodiments, such embodiments are not intended to limit the scope of the invention to the particular form set forth, but, is intended to cover such alternatives, modifications, and equivalents as may be included within the spirit and scope of the invention as defined in the appended claims.
Patent applications in class Containing or obtained from Aloe (e.g., aloe vera, etc.)
Patent applications in all subclasses Containing or obtained from Aloe (e.g., aloe vera, etc.)